Surface carboxylic acid functionalized water-soluble rare earth doped barium fluoride chloride nano-luminescent material and preparation method thereof

Abstract

The invention provides a surface carboxylic acid functionalized water-soluble rare earth doped barium fluoride chloride nano-luminescent material and a preparation method thereof, and relates to the preparation of a surface-functionalized water-soluble nano-luminescent material. The composition of the barium fluoride chloride nano-luminescent material prepared by the present invention is: XLn3+-(1-x)BaFCl (Ln=Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb ; x=0-60mol%). Using PAA as a surfactant, a water-soluble rare earth-doped barium fluoride chloride nanoluminescent material with surface carboxylic acid functionalization was prepared by one-step reaction. Through transmission electron microscope, infrared absorption spectrum, thermogravimetric curve and other test methods, it is proved that PAA is effectively coated on the surface of nanoparticles. The obtained nanopowder has good water solubility, and the carboxylic acid groups on its surface lay the foundation for the next step of binding biomolecules. By doping with different rare earth ions, the material can realize strong fluorescence emission of rare earth ions from the visible to the infrared range.

Description

[0001] technical field [0002] The invention relates to a water-soluble nano-luminescent material with surface functionalization and a preparation method thereof, in particular to a water-soluble rare-earth-doped barium fluoride chloride (BaFCl) nano-luminescence material with surface carboxylic acid functionalization and a preparation method thereof. Background technique [0003] Rare earth-doped nanoparticles are widely used in the fields of biological imaging and fluorescent immunoassay due to their stable luminescent properties, large Stokes shift, low toxicity, and multicolor luminescence. As a bioluminescent labeling material, nanoparticles need to have good water solubility and have functional groups on the surface that can bind biomolecules, such as carboxyl and amino groups. However, since the vast majority of nanoluminescent materials are synthesized under organic solvent conditions, they are neither water-soluble nor have functionalized surfaces for binding to bi...

AI Technical Summary

Problems solved by technology

However, since the vast majority of nanoluminescent materials are synthesized under organic solvent conditions, they are neither water-soluble nor have functionalized surfaces for binding to biomolecules.

Although silica coating, layer by layer, and ligand exchange methods can modify the surface of nanomaterials so that they can be dissolved in water or connect biomolecules, there are many limitations in these methods. The problem

Although the method of silica coating is widely used, the operation process is complicated, the repeatability is poor, and it is easy to cause particle agglomeration; the layer-by-layer adsorption is simple to operate, but it is not selective for biomolecules, which leads to the confusion of connecting biomolecules. Moreover, the linked biomolecules are also easy to dissociate; ligand exchange has high selectivity for biomolecules, but it must be carried out under the protection of high temperature and inert atmosphere, resulting in harsh experimental conditions.

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