A kind of preparation method of glucosamine sulfate

Abstract

The invention provides a preparation method of glucosamine sulfate. According to the hydrolysis in the preparation method, chitosan and a bisulfate-containing acidic ionic liquid undergo a hydrolysis reaction in water for 2-5 hours, wherein the quality and volume ratio of chitosan to the bisulfate-containing acidic ionic liquid is 1:3-5, the water amount is 3-6 times the weight of chitosan, and the reaction temperature is 80-140 DEG C. According to the method, there is no acid fog and tail gas during the production process; and the product contains no chloride ion and is safe with no pollution. With the use of the bisulfate-containing acidic ionic liquid, the reaction time is short, the yield is high, the ionic liquid can be repeatedly used, the whole production technology is simple, the purity and the yield of the product obtained is high, the cost is low, and the preparation method provided by the invention is a green, environmentally friendly and high efficient production technology.

Description

technical field [0001] The invention belongs to the technical field of electrochemical analysis and detection, and in particular relates to a preparation method of glucosamine sulfate. Background technique [0002] There are currently 355 million people with arthritis worldwide. In Asia, one out of every six people suffers from arthritis, the world's number one disabling disease, at some point in their life. At present, it is estimated that there are more than 100 million arthritis patients in mainland China, and the number is still increasing . Severe pain can lead to loss of working ability, which is a major damage to social development and human health. [0003] Glucosamine sulfate can significantly relieve the pain of arthritis and rheumatism patients and improve, prevent, treat and repair connective tissue damage. It also has certain curative effect on bone and arthritis inflammation, and also helps the healing of acute and chronic inflammation. Therefore, It also ha...

AI Technical Summary

Problems solved by technology

In the former production process, hydrochloric acid is used when preparing glucosamine hydrochloride. The pollution caused by hydrochloric acid mist damages the environment and the health of workers. After ion exchange, the mixture needs to be dried by freeze-drying method. Because it contains acetone, it is difficult to freeze-dry, so it is difficult to industrialize large-scale production; the organic strong alkali method first converts glucosamine hydrochloride into glucosamine base, and controls the fuming sulfuric acid by adjusting the pH. The amount of addition, the composition of glucosamine sulfate prepared by each batch is different, and it is difficult to stabilize the production

And use sulfuric acid to directly degrade, this method consumes a large amount of organic solvents, the production cost is higher, and the residual organic solvents and non-monosaccharide compound components greatly affect the purity of the product, and there are still key technologies to be broken through as health care products and pharmaceutical applications. A large amount of concentrated sulfuric acid in production will corrode the reactor, and it is difficult to recover

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