Process for extracting heparin sodium from pig lung and co-producing polypeptide protein powder

Abstract

A process for extracting heparin sodium from pig lungs and co-producing polypeptide protein powder. Two products of heparin sodium and polypeptide protein powder can be obtained at the same time with one feeding. It includes the following steps: (1) raw material pretreatment; (2) enzymatic hydrolysis; (3) salt hydrolysis twice; (4) slag (protein) removal and clear liquid collection; (5) ultrafiltration and concentration to remove ash; (6) Ammonium salt precipitation; (7) precipitation of heparin sodium, and vacuum drying to obtain crude heparin sodium; (8) enzymatic precipitation; (9) decolorization; (10) pressure filtration; (11) spray drying. The process is co-production, which has a higher utilization rate of equipment than a single production process, saves raw materials, auxiliary materials, and manpower, and can reduce the production cost of heparin sodium and polypeptide protein powder; make full use of my country's pig lung resources to increase the added value of pig lung; reduce protein-containing waste Liquid waste slag pollutes the environment, and turning waste into treasure is an effective way to supplement the shortage of protein feed resources in our country.

Description

Technical field: [0001] The invention discloses a process for extracting heparin sodium from pig lungs and co-producing polypeptide protein powder. Background technique: [0002] Heparin Sodium (Heparin Sodium) is an acidic mucopolysaccharide containing a sulfate group. It is a typical anticoagulant drug, which can prevent the coagulation process of blood and prevent the formation of thrombus. Although heparin sodium has been used clinically for more than 60 years, so far there is no product that can completely replace it, so it is still the most important anticoagulant and antithrombotic sublimation drug, and it can only be obtained from animals. It is extracted from some tissues and cannot be synthesized artificially. [0003] Polypeptide protein powder is rich in protein, amino acid, oligopeptide, calcium, phosphorus, cellulose and some other macro and trace elements, and can be used as feed in weaned piglets, sows and aquaculture. Easily digested and absorbed by the bo...

AI Technical Summary

Problems solved by technology

[0004] At present, heparin sodium is generally extracted from pig small intestine and bovine lung as raw materials at home and abroad. The waste liquid and waste residue are usually discarded, which pollutes the environment and wastes raw materials.