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Graphene/hydroxyapatite nano composite and preparation method thereof

A nanocomposite material, hydroxyapatite technology, applied in the field of nanocomposite materials and biomaterials, can solve the problems of small cell toxicity, large specific surface area, etc., and achieve good biocompatibility, large specific surface area, and easy-to-obtain raw materials. Effect

Inactive Publication Date: 2012-07-11
JIANGSU UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

[0005]In order to improve the structure and morphology of hydroxyapatite and reduce the difficulty of preparation at the same time to achieve a win-win situation, many researchers have turned their attention to hydroxyapatite In the study of modification and compounding of limestone, modified hydroxyapatite nanocomposites were prepared by adding modifiers and composite matrix; such as Damia et al [Mater. Lett. , 2006, 60, 3192?3196] Using silane coupling agents A-1130 and A-187 to modify the surface of hydroxyapatite, and then using the interaction between silane groups and metals to wrap hydroxyapatite On the metal surface, this method can better control its crystallinity and porosity; since graphene was discovered, due to its high strength (130 GPa) and high tensile modulus (1.01 TPa), Light weight, large specific surface area (2600 m2 / g), good biocompatibility and low cytotoxicity, it is considered to be an ideal choice for the reinforcement phase of composite materials; amino acid as a good It can also effectively regulate and modify the structure of hydroxyapatite materials under certain conditions. At present, graphene / hydroxyapatite is prepared by hydrothermal method using graphene oxide as a precursor and amino acid as a structure regulator. Stone nanocomposites have not been reported

Method used

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  • Graphene/hydroxyapatite nano composite and preparation method thereof
  • Graphene/hydroxyapatite nano composite and preparation method thereof
  • Graphene/hydroxyapatite nano composite and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Disperse 20 mg of graphene oxide in 20 ml of deionized water and sonicate for 3 hours to obtain a graphene oxide solution, add 3.33 g of anhydrous calcium chloride to the graphene oxide solution after ultrasonication, and stir for 10 minutes to obtain a mixed solution A; Dissolve 1.4 ml of 98% concentrated phosphoric acid solution in 20 ml of deionized water to form a dilute phosphoric acid solution, and prepare a 3 mol / L dilute hydrochloric acid solution; weigh 4.5 g of glycine and add it to the dilute phosphoric acid solution, and stir for 10 minutes to obtain a mixed solution B; Use dilute hydrochloric acid solution to adjust the pH of the mixed solution B to 7.5, and continue to stir for 10 minutes; add the mixed solution A to the mixed solution B drop by drop, stir for 15 minutes, and then transfer the mixed solution to the inner tank of the 100 ml reactor placed in a stainless steel jacket, sealed, and kept at 160 °C for 24 hours for hydrothermal treatment, then le...

Embodiment 2

[0022] Disperse 50 mg of graphene oxide in 20 ml of deionized water and sonicate for 5 hours to obtain a graphene oxide solution, add 3.33 g of anhydrous calcium chloride to the sonicated graphene oxide solution, and stir for 10 minutes to obtain a mixed solution A; measure Dissolve 1.4 ml of 98% concentrated phosphoric acid solution in 20 ml of deionized water to form a dilute phosphoric acid solution, and prepare a 3 mol / L dilute hydrochloric acid solution; weigh 4.5 g of glycine and add it to the dilute phosphoric acid solution, and stir for 10 minutes to obtain a mixed solution B; Adjust the pH of the mixed solution B to 8 with dilute hydrochloric acid solution, and continue to stir for 10 minutes; add the mixed solution A dropwise to the mixed solution B, stir for 15 minutes, and then transfer the mixed solution to the inner tank of the 100 ml reactor placed in a stainless steel jacket, sealed, and kept at 180 °C for 18 hours for hydrothermal treatment, then let the reacto...

Embodiment 3

[0025] Disperse 100 mg of graphene oxide in 20 ml of deionized water and ultrasonically obtain a graphene oxide solution for 4 hours, add 3.33 g of anhydrous calcium chloride to the graphene oxide solution after ultrasonication, and stir for 10 minutes to obtain a mixed solution A; Dissolve 1.4 ml of 98% concentrated phosphoric acid solution in 20 ml of deionized water to form a dilute phosphoric acid solution, and prepare a 3 mol / L dilute hydrochloric acid solution; weigh 4.5 g of glycine and add it to the dilute phosphoric acid solution, and stir for 10 minutes to obtain a mixed solution B; adjust the pH of the mixed solution B to 8.5 with dilute hydrochloric acid solution, and continue to stir for 10 minutes; add the mixed solution A to the mixed solution B drop by drop, stir for 15 minutes, and then transfer the mixed solution to the inner tank of the 100 ml reactor placed in a stainless steel jacket, sealed, and kept at 200 °C for 12 hours for hydrothermal treatment, then ...

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Abstract

The invention relates to a graphene / hydroxyapatite nano composite and the preparation method thereof, particularly relates to a hydrothermal method for preparing graphene / hydroxyapatite nano composite through the assistance of amino acid, and belongs to the field of nano composite and biological material. According to the invention, graphene oxide is placed in deionized water for ultrasonic dispersion, and calcium chloride anhydrous is added for stirring, so as to form mixed solution A; amino acid is added into dilute phosphoric acid for stirring so as to form solution b, the dilute hydrochloric acid solution is used for adjusting the solution to enable the PH value to be 7.5 to 8.5, finally the mixed solution A and the mixed solution B are mixed to transfer into a polytetrafluoroethylene reaction kettle for hydro-thermal reaction, and after the reaction is finished, the composite can be obtained through centrifugating, cleaning and vacuum drying the product. The invention has the advantages that the operating process is relatively simple, the structure is controllable, the surface appearance is better, the specific surface area is larger, the dimension is even, and the like.

Description

technical field [0001] The invention relates to a graphene / hydroxyapatite nanocomposite material and a preparation method thereof, in particular to a method for preparing a graphene / hydroxyapatite nanocomposite material by amino acid-assisted hydrothermal treatment, belonging to nanocomposite materials and biological material field. Background technique [0002] Bioceramic hydroxyapatite (Hydroxyapatite, HA) is the main inorganic component of human and animal bones and teeth, accounting for about 45% of dry bone tissue. The apatite in human natural bone is mainly in the form of nano-scale needle crystals along the Distributed in a certain orientation in the collagen network, thereby improving the implantation effect of the composite bone material; due to its good biological activity and biocompatibility, stable chemical properties and diverse structures, it can be used in artificial bone, drug sustained release , gas sensors, catalysts, optoelectronic materials, chemical e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01M4/36B82Y30/00B82Y40/00
CPCY02E60/12Y02E60/10
Inventor 杨小飞李忠唐华张蓉仙高庆侠夏娴娴刘恒
Owner JIANGSU UNIV
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