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Porous hydroxyapatite and preparation method and application thereof

A hydroxyapatite, uniform technology, applied in the field of medicine, can solve problems such as no relevant reports, and achieve the effects of good physical stability, inhibition of recrystallization, and improvement of drug loading

Inactive Publication Date: 2012-07-18
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The surface of hydroxyapatite can be bonded with human tissue to achieve complete affinity or be partially or completely absorbed and replaced by human tissue. It can be used as a safe and effective biomedical material and has been widely used in bone grafting and bone replacement materials. and protein-loaded drugs for sustained-release research, but as a poorly soluble drug carrier for oral administration, there is no relevant report for improving the dissolution rate and bioavailability of poorly soluble drugs

Method used

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  • Porous hydroxyapatite and preparation method and application thereof
  • Porous hydroxyapatite and preparation method and application thereof
  • Porous hydroxyapatite and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Accurately weigh 3g F127 and 1g CTAB into 100ml of water, heat to 80°C to dissolve completely, then add 2.775g of anhydrous calcium chloride and 1.980g of diammonium hydrogen phosphate (the molar ratio of calcium to phosphorus is 5:3), and use Adjust the pH of the solution to 10 with ammonia water, stir for 2 hours, make the solution fully mixed and react, put the reacted solution in an autoclave at 100°C for hydrothermal reaction for 24 hours, wash with deionized water and absolute ethanol three times until neutral, and use The precipitate was separated by suction filtration, dried in vacuum at 60°C for 24 hours, and calcined at 550°C for 6 hours to remove the organic template and finally obtain porous hydroxyapatite.

Embodiment 2

[0040] Accurately weigh 1g F127 and 0.3g CTAB into 100ml of water, heat to 70°C to dissolve completely, then add 2.775g of anhydrous calcium chloride and 1.980g of diammonium hydrogen phosphate (the molar ratio of calcium to phosphorus is 5:3), Adjust the pH of the solution to 11 with ammonia water, stir for 2 hours, make the solution fully mixed and react, put the reacted solution in an autoclave at 80°C for hydrothermal reaction for 24 hours, wash with deionized water and absolute ethanol three times until neutral, Vacuum drying at 50°C for 48 hours, high-temperature calcination at 500°C for 6 hours, removal of the organic template, and finally obtaining porous hydroxyapatite.

Embodiment 3

[0042] Accurately weigh 1g of F127 and 0.3g of CTAB and add it to 100ml of water and ethanol mixed solvent (and the ratio is 1:1), heat to 80°C to dissolve completely, then add 5.852g of calcium nitrate tetrahydrate and 1.980 of diammonium hydrogen phosphate g (the molar ratio of calcium to phosphorus is 5:3), adjust the pH of the solution to 10 with ammonia water, stir for 3 hours, make the solution fully mixed and react, put the reacted solution in an autoclave at 70°C for hydrothermal reaction for 24 hours, and use deionized water and anhydrous ethanol for three times to neutrality, vacuum drying at 50°C for 48 hours, high-temperature calcination at 500°C for 6 hours, removing the organic template and finally obtaining porous hydroxyapatite.

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Abstract

The invention belongs to the technical field of medicaments and relates to porous hydroxyapatite, a preparation process thereof and application thereof to difficultly soluble medicament feeding system. A hydrothermal template method is adopted in the process, namely, a triblock copolymer F127 and hexadecyl trimethyl ammonium bromide (CTAB) serve as templates to prepare the porous hydroxyapatite under a hydrothermal condition. The porous hydroxyapatite is large in specific surface area, stable in performance and good in biocompatibility, does not have toxic or side effects, has a plurality of hydrophilic groups on the surface, and is suitable to be used as a carrier of a difficultly soluble medicament. The medicament is embedded and absorbed by a solvent method or a melting method, so that the medicament is uniformly dispersed in the aperture of the carrier and on the surface of the carrier. By the system, the water-solubility of the difficultly soluble medicament can be obviously improved, the dissolution speed is improved, and the bioavailability of the medicament is improved when the medicament is orally taken.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a porous hydroxyapatite (porous hydroxyapatite) with biological activity and physiological compatibility, a preparation method thereof and an application as an insoluble drug carrier. Background technique [0002] Due to the advantages of strong compliance, good stability, and economical safety, oral preparations have an absolute advantage in the market sales ratio, and are currently the preferred route of administration for most drugs. However, more than 1 / 3 of the drugs in the United States Pharmacopoeia, which contains the most drugs, are poorly water-soluble drugs; at the same time, about 40% of the drugs are poorly water-soluble drugs in the research of innovative drugs. Difficulty in drug dissolution greatly affects its oral bioavailability. Especially for class II drugs in the classification of biopharmaceuticals, that is, drugs that are difficult to dissolve and absorb ea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61K47/02
Inventor 王思玲王晶赵勤富郑力
Owner SHENYANG PHARMA UNIVERSITY
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