Porous hydroxyapatite and preparation method and application thereof

A hydroxyapatite, uniform technology, applied in the field of medicine, can solve problems such as no relevant reports, and achieve the effects of good physical stability, inhibition of recrystallization, and improvement of drug loading
CN102583286AInactive Publication Date: 2012-07-18SHENYANG PHARMA UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2012-07-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of medicaments and relates to porous hydroxyapatite, a preparation process thereof and application thereof to difficultly soluble medicament feeding system. A hydrothermal template method is adopted in the process, namely, a triblock copolymer F127 and hexadecyl trimethyl ammonium bromide (CTAB) serve as templates to prepare the porous hydroxyapatite under a hydrothermal condition. The porous hydroxyapatite is large in specific surface area, stable in performance and good in biocompatibility, does not have toxic or side effects, has a plurality of hydrophilic groups on the surface, and is suitable to be used as a carrier of a difficultly soluble medicament. The medicament is embedded and absorbed by a solvent method or a melting method, so that the medicament is uniformly dispersed in the aperture of the carrier and on the surface of the carrier. By the system, the water-solubility of the difficultly soluble medicament can be obviously improved, the dissolution speed is improved, and the bioavailability of the medicament is improved when the medicament is orally taken.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to a porous hydroxyapatite (porous hydroxyapatite) with biological activity and physiological compatibility, a preparation method thereof and an application as an insoluble drug carrier. Background technique

[0002] Due to the advantages of strong compliance, good stability, and economical safety, oral preparations have an absolute advantage in the market sales ratio, and are currently the preferred route of administration for most drugs. However, more than 1 / 3 of the drugs in the United States Pharmacopoeia, which contains the most drugs, are poorly water-soluble drugs; at the same time, about 40% of the drugs are poorly water-soluble drugs in the research of innovative drugs. Difficulty in drug dissolution greatly affects its oral bioavailability. Especially for class II drugs in the classification of biopharmaceuticals, that is, drugs that are difficult to dissolve and absorb ea...

Claims

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