Application of allopurinol compound in preparing information treatment drug, preparation method and prepared novel drug

Abstract

The invention discloses application of an allopurinol compound in preparing an information treatment drug, a preparation method of the allopurinol compound and a novel drug prepared by the preparation method. During the treatment, the information treatment drug does not directly touch a human body, drug substance components are not consumed, chemotherapy effects can be achieved only by drug information physiotherapy, and the therapy window is enlarged more than one thousand times, and side effects of the chemotherapy are avoided. After allopurinol is used as the information treatment drug, the effective component content is not changed, and allopurinol can be used secondarily and effectively as a chemotherapy normal preparation.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a novel drug of allopurinol. Background technique [0002] The compound Allopurinol is 1H-pyrazolo[3,4-d]pyrimidin-4-ol, chemical formula C 5 h 4 N 4 O, molecular weight 136.11. The properties are white or off-white crystalline powder, almost odorless. Slightly soluble in ethanol in water, insoluble in chloroform or ether, easily soluble in 0.1mol / L potassium hydroxide or sodium hydroxide solution. Allopurinol is an anti-gout drug, clinically used to treat hyperuricemia, gout, tophi and uric acid kidney stones. Pharmaceutical preparations of allopurinol include tablets and the like. The known allopurinol drugs are all used as chemotherapeutic drugs, which allow the compound allopurinol molecules to enter the human body (through oral absorption into the blood), distribute to various tissues, and produce pharmacological effects through the chemical reaction of drug molecules in the h...

AI Technical Summary

Problems solved by technology

In the prior art, allopurinol is used as a chemotherapeutic drug, and there are defects that cannot be overcome so far. The first is the toxic and side effects on the human body, and its annoying adverse reactions include anaphylaxis, blood system leukocytes, thrombocytopenia, anemia , urinary system oliguria, interstitial nephritis, renal failure or even purine nephropathy or stones, nervous system headache, dizziness, numbness of hands and feet, hair loss, fever, enlarged lymph nodes, etc., gastrointestinal nausea and vomiting, abdominal pain, diarrhea, loss of appetite, Oral ulcers, gastrointestinal discomfort, abnormal liver function, allergic hepatic necrosis, cholecystitis, etc.; second, the treatment window is small, and due to the toxic and side effects on the human body, the effective dose that can be used is very small, which limits the therapeutic effect. The maximum dosage is 100mg once, 300mg a day, if the dosage exceeds the maximum, it can cause poisoning; the third is that there is only one use of chemotherapy drugs, and the drugs will be metabolized and decomposed or excreted when they enter the human body, so they cannot be used twice

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