Compound butenafine hydrochloride nanometer cream and preparation method thereof
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A technology of butenafine hydrochloride and nanoemulsion, which is applied in the field of medicine, can solve the problems of increasing skin irritation and side effects, clobetasol propionate is not suitable for long-term use, butenafine hydrochloride is unstable, etc. Onset time, clear and transparent appearance, and the effect of improving drug efficacy
Inactive Publication Date: 2012-07-25
NORTHWEST A & F UNIV
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The common defects of these dosage forms are: 1) As externally used drugs, the transdermal absorption efficiency of these dosage forms is low, which increases the dosage and time of medication; 2) All use organic solvents to disperse the drugs, which increases skin irritation and toxicity. Side effects; 3) butenafine hydrochloride is unstable and prone to failure
This product is insoluble in water, and it is often used as a cream in clinical practice, so the transdermal absorption efficiency is limited, which undoubtedly prolongs the treatment time
Because clobetasol propionate is not suitable for long-term use, long-term medication may cause hypercorticism, thus greatly limiting its clinical application, a dosage form that can increase the transdermal absorption efficiency of clobetasol propionate seems extremely important
Method used
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Embodiment 1
[0063] (1) Weigh 27 g of Tween-80, 10 g of absolute ethanol, 0.5 g of polyethylene glycol-400, 1 g of ethyl acetate, 1.5 g of isopropyl myristate, 1 g of butenafine hydrochloride, Clobetasol propionate 0.05 g, deionized water 58.95 g, a total of 100 g for standby;
[0064] (2) Mix the surfactant and co-surfactant evenly, then add the oil phase, and mix well;
[0065] (3) Add butenafine hydrochloride and mix well;
[0066] (4) Add clobetasol propionate and mix well;
[0067] (5) Slowly add deionized water at room temperature, and stir while adding deionized water until a clear, transparent, colorless or yellowish liquid with low viscosity and good fluidity is formed, and its weight is called 100 g.
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Abstract
The invention discloses compound butenafine hydrochloride nanometer cream. The compound butenafine hydrochloride nanometer cream is prepared by raw materials including, by weight percentage, from 20 to 45% of surfactant, from 8 to 25% of cosurfactant, from 2 to 4% of oil, from 0.8 to 2% of butenafine hydrochloride, from 0.02 to 0.1% of clobetasol propionate and the balance deionized water. The sum of the mass percentages of the raw materials is 100%. The compound butenafine hydrochloride nanometer cream has multiple effects of fungus killing, fungus resistance, inflammation diminishing, itching relieving and the like, and has a remarkable effect when used for treating superficial skin dermatomycosis (such as tinea of feet and hands, tinea corporis-cruris, tinea versicolor, cutaneouscandidiasis and the like). The compound nanometer cream remarkably increases activity of two medicines, takes effect rapidly, has a lasting effect, prevents the superficial skin dermatomycosis from recurring, and has a wide market prospect in the field of medicine.
Description
technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of an antifungal drug butenafine hydrochloride for external use, in particular to a transparent and stable oil-in-water compound butenafine hydrochloride nanoemulsion and a preparation method thereof. [0002] Background technique [0003] Butenafine Hydrochloride is a new antifungal drug of benzylmethylamine derivatives. Its chemical structure and mode of action are similar to allylamine antifungal drugs. It has strong antibacterial and bactericidal activities and a wide antibacterial spectrum. features. It plays a role by specifically inhibiting squalene epoxidase and preventing the synthesis of ergosterol in the fungal membrane. Butenafine hydrochloride has a bactericidal effect on dermatophytes, the minimum bactericidal concentration (MFC) is 4-130 times lower than that of nafine, naftifine, clotrimazole and bifonazole, and the minimum inhibitory concentration (MIC) ...
Claims
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