Ferroferric oxide calcium phosphate nuclear shell magnetic nanoparticle and preparation method thereof by biological mineralization method

Abstract

The invention discloses a ferroferric oxide calcium phosphate nuclear shell magnetic nanoparticle and a preparation method thereof by a biological mineralization method and belongs to the technical field of magnetic particles. A magnetic ferroferric oxide nanoparticle serves as a core, wherein the mean grain size of the particle is 27 to 38nm; and a calcium phosphate material serves as a shell layer, wherein the thickness of the shell layer is 4 to 20nm. The preparation method comprises the following steps that the ferroferric oxide magnetic nanoparticle is prepared and then is modified by a surface modifier; the modified ferroferric oxide magnetic nanoparticle is added into simulated human body fluid which is prepared and has the concentration of 1 to 10 times; the modified ferroferric oxide magnetic nanoparticle is mineralized; and the product is washed, subjected to magnetic separation and dried to obtain the ferroferric oxide calcium phosphate nuclear shell magnetic nanoparticle. The preparation method is simple in operation, mild in preparation process condition, wide in raw material source and environment friendly. The prepared nuclear shell nanoparticle has biological activity and has good application prospect in the field of biomedicine, such as tissue engineering and medicine carrying.

Description

technical field

[0001] The invention relates to a nano-magnetic particle with a biologically active core-shell structure and a preparation method thereof, in particular to a biomineralization method for preparing ferric ferric oxide calcium phosphate core-shell nano-magnetic particle, which belongs to the technical field of magnetic particles. technical background

[0002] Ferroferric oxide is a very important magnetic material with a cubic reverse spinel structure. Its unique electrical and magnetic properties make it widely used in magnetic fluids and magnetic recording materials. For nanometer scale Fe3O4, due to its compatibility with biological tissues, electrical and magnetic properties related to size and shape, it has been widely used in the field of biomedicine. Superparamagnetic iron oxide nanoparticles with suitable surface chemistry can be used in numerous in vivo applications, such as in vivo magnetic resonance contrast enhancement, tissue repair, immunoassay, ...

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