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Hydrogel paste and preparation method thereof

The technology of hydrogel patch and hydrogel layer is applied in the field of hydrogel patch and its preparation, which can solve the problems of short action time, poor sustained release effect, easy oxidation and the like of the hydrogel patch, so as to improve the sustained release performance. , strong anti-oxidative properties, prolong the effect of action time

Active Publication Date: 2013-09-25
佛山拜澳生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a hydrogel patch and its preparation method, which aims to solve the problems of the existing hydrogel patch such as short action time, poor slow-release effect, instability and easy oxidation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Prepare the following substances by mass percentage:

[0055] Whitening agent: zinc glycyrrhizinate 0.03, glycyrrhizic acid 0.1% Cross-linking regulator: disodium edetate 0.08% Polymer skeleton material: polyvinyl alcohol 4% Acid-base regulator: tartaric acid 0.55% Tackifier: Polyvinylpyrrolidone 1.5% Humectant: Propylene Glycol 6% Filler: ceramic clay 0.5% Preservative: Methyl Chlorisothiazolinone 0.03% Cross-linking agent: glutaraldehyde 0.1% Distilled water: balance

[0056] Step 1: The polymer skeleton material is swollen with distilled water, and whitening agent, thickener, moisturizer, and filler are added;

[0057] Step 2: Dissolve the cross-linking agent, cross-linking regulator, acid-base regulator, and preservative in an appropriate amount of distilled water, and add the swollen polymer skeleton material

[0058] Step 3: mixing the above-mentioned components to prepare a hydrogel patch matrix;

[0059] Step 4: After ...

Embodiment 2

[0064] Whitening agent: dipotassium glycyrrhizinate 0.1% Cross-linking regulator: disodium edetate 0.5% Polymer skeleton material: sodium polyacrylate 8%, carboxypropyl methylcellulose 2% Acid-base regulator: tartaric acid 0.5% Tackifier: Polyvinylpyrrolidone 1% Humectant: Butylene Glycol 7% Filler: Kaolin 0.5% Preservative: Methyl Chlorisoxazolone 0.05% Cross-linking agent: aluminum glycinate 0.08% Distilled water: balance

[0065] Step 1: The polymer skeleton material is swollen with distilled water, and whitening agent, thickener, moisturizer, and filler are added;

[0066] Step 2: Dissolve the cross-linking agent, cross-linking regulator, acid-base regulator, and preservative in an appropriate amount of distilled water, and add the swollen polymer skeleton material

[0067] Step 3: mixing the above-mentioned components to prepare a hydrogel patch matrix;

[0068] Step 4: After coating and cutting the hydrogel patch matrix, let it...

Embodiment 3

[0073] Whitening agent: monopotassium glycyrrhizinate 0.1%, glycyrrhetinic acid 0.2% Cross-linking modifier: tetrasodium edetate 0.06% Polymer skeleton material: sodium polyacrylate 7%, carboxyethyl cellulose 3% Acid-base regulator: 0.5% gluconic acid Tackifier: Polyvinylpyrrolidone 0.8% Humectant: Glycerol 8% Filler: Diatomaceous Earth 1% Preservative: Methyl Chlorisoxazolone 0.02% Cross-linking agent: aluminum glycinate 1% Distilled water: balance

[0074] Step 1: The polymer skeleton material is swollen with distilled water, and whitening agent, thickener, moisturizer, and filler are added;

[0075] Step 2: Dissolve the cross-linking agent, cross-linking regulator, acid-base regulator, and preservative in an appropriate amount of distilled water, and add the swollen polymer skeleton material

[0076] Step 3: mixing the above-mentioned components to prepare a hydrogel patch matrix;

[0077]Step 4: After coating and cutting the hydr...

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Abstract

The invention discloses a hydrogel paste and a preparation method thereof, wherein the hydrogel paste is composed of three layers: a backing layer, a hydrogel layer and a protecting film layer. The hydrogel layer is arranged between the backing layer and the protecting film layer; the hydrogel layer comprises the following components: 5-10% of macromolecule framework material, 0.5-2% of tackifier, 0.5-1% of filler, 0.03-1% of cross-linking agent, 0.03-1% of cross-linking regulator, 0.5-1% of acid-base regulator, 3-10% of humectant, 0.01-2% of preservative and the balance of distilled water; and the hydrogel layer also comprises 0.01-10% of active ingredient, such as whitening agent, antiphlogistic agent, essential oil, and the like. The hydrogel paste has an excellent slow-release property; the action time of the hydrogel paste is prolonged; a cross-linking effect of the cross-linking agent is fully utilized, so that the hydrogel paste is excellent in viscosity and cohesive strength; and the hydrogel paste is high in oxidation resistance, is safe and free from toxic side effect and is suitable for the treatment of dry, fragile and sensitive skins.

Description

technical field [0001] The invention relates to the field of hydrogel stickers, in particular to a multifunctional hydrogel sticker and a preparation method thereof. Background technique [0002] Hydrogels are gels in which water is the dispersion medium. Hydrogel is to introduce a part of hydrophobic groups and hydrophilic residues into the water-soluble polymer with a network structure, and the hydrophilic residues are combined with water molecules to connect the water molecules inside the network, while the Hydrophobic residues swell with water. It is a cross-linked polymer with a polymer network system, which is soft, can maintain a certain shape, and can absorb a large amount of water. [0003] As a material with high water absorption and high water retention, hydrogel is widely used in various fields, such as: facial mask, antipyretic patch, pain relief patch, agricultural film, anti-condensation agent in construction, humidity control agent, petrochemical industry, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K45/00A61K47/36A61K47/32A61P31/04A61K8/02A61K8/97A61K8/63A61K8/73A61K8/81A61Q19/02A61K8/92
Inventor 黄庆
Owner 佛山拜澳生物科技有限公司
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