Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Emergency contraceptive

A technology for emergency contraception and pulmonary drug delivery, which is used in drug combination, drug delivery, and pharmaceutical formulations to achieve good compliance.

Inactive Publication Date: 2012-09-12
LYKA LABS LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent does not address the use of nasal administration of synthetic alternatives such as levonorgestrel

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Liposomes:

[0057] Numbering raw material composition 1 Levonorgestrel and / or ethyl estradiol 1:1 or 1 2 Drugs: HSPC: DSPG: Cholesterol 1:12:1:1 (molar ratio) 3 α-tocopherol Equivalent to 1% of lecithin 4 Chloroform:Methanol (as solvent) 1：2 5 Double distilled water (as a hydration medium) 1ml / 20 mg solid content

[0058] Liposome preparation process:

[0059] Thin film hydration method:

[0060] (a) Lecithin, cholesterol, α-tocopherol (equivalent to 1% by weight of lecithin) and levonorgestrel and / or ethyl estradiol were dissolved in chloroform:formaldehyde in a round bottom flask {1 :2} in the mixture;

[0061] (b) Dry the solution from step (a) by rotating the round bottom flask at 120 rpm under vacuum at 30 °C, followed by drying under a nitrogen blanket for 20 min until a smooth, uniform and dry film is formed;

[0062] (c) hydrating the film formed in step (b) by double-distilled water at the glass trans...

Embodiment 2

[0073] Solution:

[0074] Numbering raw material composition 1 Levonorgestrel and / or ethyl estradiol 0.5-1% 2 Propylene Glycol 5-10% 3 polyethylene glycol 400 10-15% 4 ethanol up to 5% 5 Akola up to 1% 6 Chitosan acetate 0.5%-1% 7 double distilled water until 100%

[0075] making process:

[0076] (a) Disperse accurately weighed chitosan powder in 0.01% acetic acid;

[0077] (b) using a magnetic stirrer to stir the dispersion in step (a) until a clear solution is obtained;

[0078] (c) freezing the solution of step (b) overnight to remove entrapped air;

[0079] (d) adjust the final concentration of chitosan to 1% mass volume ratio;

[0080] (e) Accurately weigh and disperse levonorgestrel and / or ethyl estradiol in double distilled water, or alternatively use the levonorgestrel and / or ethyl estradiol lipid of Example 1 plastid;

[0081] (f) sonicating the solution of step (e) for 1 hour to obtain partic...

Embodiment 3

[0088] powder:

[0089] Numbering raw material composition 1 Microemulsified drug / drug encapsulated in liposome (Example 1) 0.5-1% 2 HPMC 1% 3 Grind lactose 400 or medicinal lactose 325 until 100%

[0090] making process:

[0091] (a) centrifugation of the optimal batch of liposomes prepared according to Example 1 to form microparticles;

[0092] (b) hydrating the microparticles of step (a) with a desired amount of sucrose-containing hydration medium to obtain different lipid:sucrose mass ratios to form a suspension;

[0093] (c) The suspension from step (b) was frozen overnight at -40°C and dried under negative substitution pressure for 24 hours to obtain porous masses;

[0094] (d) mixing ground lactose 400 (lactose) or medicinal lactose 325 (trehalose) and HPMC with the porous block of step (c) to form a powder;

[0095] (e) sieve the powder of step (d) through #200 and #240 sieves;

[0096](f) Capsules (type '2') of the individua...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses an emergency contraceptive formulation for nasal and / or pulmonary administration comprising of levonorgestrel optionally in combination with ethylestradiol. The said formulation can be in form of solution, suspension or carrier based systems selected from microemulsion and liposomes.

Description

field of invention [0001] The present invention relates to the field of drug delivery. In particular, the invention relates to nasal and / or pulmonary routes of administration of emergency contraceptives comprising synthetic progesterone or synthetic estrogen or a combination of both. Background of the invention [0002] Birth control, more commonly known as "contraception," is one or more acts, devices, sexual practices, or subsequent drug regimens intended to prevent or reduce the likelihood of pregnancy or childbirth. Birth control includes about three methods, namely, prevention of fertilization of an egg or "contraception"; prevention of implantation of an embryo, or abortifacient and chemical or surgically induced abortion of an embryo or fetus. [0003] The history of birth control begins with the discovery of the relationship between sexual intercourse and pregnancy. Traditionally, the method of interruption or withdrawal or extraction of sexual intercourse to avoi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K9/127A61K9/14A61K9/19A61K31/565
CPCA61K9/0043A61K9/0073A61K9/0075A61K9/1075A61K9/127A61K9/146A61K9/19A61K31/565A61K47/32A61K47/36A61P15/18
Inventor A·R·米斯拉N·I·刚德海M·R·巴加捷B·B·沙阿R·S·萨满特
Owner LYKA LABS LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com