Eye drop and preparation method and application thereof

Abstract

The invention discloses eye drop and a preparation method and application thereof. The eye drop comprises the following raw materials in percentage by weight: 0.3 to 1.5 percent of active ingredient, 0.1 to 2.5 percent of viscosity modifier, 0.5 to 2 percent of buffer salt system, 0.4 to 0.6 percent of osmotic pressure regulator, 0.01 to 0.05 percent of bacteriostatic agent and the balance of injection water. Water-soluble auxiliary materials with viscosity increasing action and moisture-keeping action and medicaments are mixed in an aqueous solution in a molecule form, so that the eye drop is comfortable, has high viscosity and can prolong the contact time between the medicaments and the cornea, improve absorption of the medicaments, improve the bioavailability, reduce the medication times, improve the compliance of patients and ensure the effectiveness of medicament treatment.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an eye drop and its preparation method and application. Background technique [0002] Drugs play an important role in clinical ophthalmology, among which anti-infective drugs and glaucoma drugs have been developed and studied more. This is because 80% to 90% of patients who go to the ophthalmology clinic have external eye infections, so the amount of anti-infective drugs is very large and widely used. Eye infections include conjunctivitis, meibomitis, meibomitis, keratitis, and global inflammation; pathogenic bacteria include bacterial infections and fungal infections. At present, the most widely used eye drops in my country's hospitals are anti-infection and anti-inflammatory drugs, among which quinolones are the main ones. [0003] The mechanism of action of fluoroquinolone eye drops is mainly to inhibit bacterial DNA gyrase and block DNA replication. It can be used clinically in oph...

AI Technical Summary

Problems solved by technology

[0004] At present, most of the eye drops are aqueous solutions of drugs. The preparation process is simple, the price is low, the patient is easy to accept, and the application is relatively wide. About 10%, most of them are lost from the eyes, and more will be lost if you blink, so the number of medications per day reaches 6 to 8 times, so the patient's compliance is reduced and the treatment effect is affected. How to improve the bioavailability of eye drops , is the key to the present concern

Images