Method for extracting synephrine and hesperidin from citrus aurantium

Abstract

The invention discloses a method for extracting synephrine and hesperidin from citrus aurantium, and relates to a method for producing and processing traditional Chinese medicine. The method comprises the following steps of: step 1, washing and crushing a citrus aurantium raw material into citrus aurantium granules; adding an acid solution for soaking the citrus aurantium granules, then carrying out percolation and extracting extract, concentrating the extract under the reduced pressure to obtain extractum, and drying the extractum under the reduced pressure to obtain synephrine; step 2, adding a weak base solution into the leached citrus aurantium granules which are extracted after being soaked by the acid solution, carrying out decoction and removing impurities, then adding a mixed solvent of sodium hydroxide and calcium chloride into the citrus aurantium granules, and extracting to obtain extract; step 3, adding hydrochloric acid into the extract for neutralization until the pH value is 3-7, standing still and crystallizating; and step 4, collecting crystalline, and drying to obtain the hesperidin. Compared with the prior art, the method can be used for extracting two components without using an organic solvent, so that the production cost is reduced, the production technology is simplified, the synephrine yield is more than 15%, the content of the synephrine is more than 10%, the hesperidin yield reaches more than 27%, and the content of the hesperidin is more than 96%; and therefore, the method is suitable for industrialized mass production.

Description

technical field

[0001] The invention relates to the field of traditional Chinese medicine production and processing, in particular to a method for extracting synephrine and hesperidin from Citrus aurantium. Background technique

[0002] Citrus aurantium is a commonly used traditional Chinese medicine. It is the dried young fruit of Rutaceae plant lime and its cultivars or sweet orange. Synephrine is one of the ingredients in Citrus aurantium, which has the functions of constricting blood vessels, raising blood pressure, expanding trachea and bronchi, anti-shock, improving metabolism, and losing weight. It is a natural stimulant and is used clinically. It is used in the treatment of bronchial asthma, hypotension, collapse and shock during surgery and anesthesia. Hesperidin has the functions of maintaining normal osmotic pressure of blood vessels, reducing the fragility of blood vessels, shortening bleeding time, and preventing arteriosclerosis. It is widely used in medical f...

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