Application of poly mannuronic acid propyl ester sulfate in preparing anti- H1N1 influenza A virus medication

A technology of propyl uronic acid and influenza virus, which can be used in antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as drug resistance, strong toxic side effects, etc.
CN102743409AInactive Publication Date: 2012-10-24OCEAN UNIV OF CHINA
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Patent Information

Authority / Receiving Office
CN Ā· China
Patent Type
Applications(China)
Current Assignee / Owner
OCEAN UNIV OF CHINA
Publication Date
2012-10-24
Estimated Expiration
Not applicable Ā· inactive patent

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Abstract

The invention provides applications of poly mannuronic acid propyl ester sulfate (PMS) in preparing anti- H1N1 influenza A virus medication. Experiments of the invention prove that PMS not only has great inhibition effect on the neuraminidase of the influenza A virus, but also has relatively good protection effect on canine kidney epithelial cells infected with the H1N1 influenza A virus, and can reduce the replication of the H1N1 virus with an effect that equal to the positive control medication ribavirin. Additionally, the PMS can effectively reduce the death rate of mice infected with the H1N1 influenza A virus and the survival time of the mice are prolonged. The poly mannuronic acid propyl ester sulfate provided by the invention has significant activity of inhibiting the neuraminidase of the H1N1 influenza A virus, and is proved to have good anti- H1N1 influenza A virus activity both in vivo and in vitro experiments, which shows the wide application prospect of the poly mannuronic acid propyl ester sulfate in preparing anti-H1N1 influenza A virus medication.
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Description

technical field

[0001] The invention belongs to the field of marine medicines, and in particular relates to the application of polymannuronate propyl sulfate in the preparation of anti-type A (H1N1) influenza virus medicines. Background technique

[0002] Influenza A is an acute respiratory infectious disease caused by Influenza A Virus (IAV), which is highly contagious and highly pathogenic, and seriously endangers human health. Influenza A virus (IAV) belongs to Orthomyxoviridae and has an enveloped negative-strand RNA virus. According to the different antigenic properties of the hemagglutinin protein (HA) and neuraminidase protein (NA) on its surface Can be divided into several subtypes, such as H1N1, H3N2 and so on. IAV has caused at least three large-scale influenza outbreaks in the last century, the worst of which was the Spanish flu outbreak in 1918-1919, which killed more than 40 million people. According to the statistics of the World Health Organization, about 60...

Claims

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