Microfluidic chip based method for synthesizing needle-like hydroxyapatite nanoparticle

A microfluidic chip, hydroxyapatite technology, applied in the direction of nanotechnology, chemical instruments and methods, phosphorus compounds, etc., to achieve the effect of accurate fusion of droplets, uniform distribution, and overcoming adsorption

Inactive Publication Date: 2014-03-26
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the co-precipitation method is favored by people for its advantages of simple equipment, low cost, and easy operation. However, the traditional co-precipitation method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Microfluidic chip based method for synthesizing needle-like hydroxyapatite nanoparticle
  • Microfluidic chip based method for synthesizing needle-like hydroxyapatite nanoparticle
  • Microfluidic chip based method for synthesizing needle-like hydroxyapatite nanoparticle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Droplet fusion and rapid mixing under different dispersed phase flow rates, using figure 1 The chip with the structure shown is shown in figure 2 . The syringe pump continuously perfuses mineral oil into reservoir A at a flow rate of 800nl / min, continuously perfuses deionized water into the first reservoir at a flow rate of 500nl / min, and injects deionized water into the second reservoir at a flow rate of 150nl / min~1000nl / min. The pool was continuously perfused with 20 mg / ml amaranth dye solution. Water-in-oil droplets (deionized water / mineral oil) are continuously formed at the first T-shaped channel 1, driven by mineral oil, they flow along the channel and meet the amaranth solution at the second T-shaped channel 2 , through the three processes of collision, oil discharge, and oil film rupture, the amaranth solution enters the droplets to achieve fusion, such as Figure 4 shown. Keeping the flow rate of the mineral oil continuous phase and the deionized water dis...

Embodiment 2

[0033] Synthesis and electron microscopy characterization of needle-like hydroxyapatite nanoparticles. Diamine hydrogen phosphate was dissolved in deionized water to prepare a 0.06 mol / L solution. The pH value of the phase solution (10-11); dissolve calcium nitrate in deionized water to prepare a 0.1mol / L solution. Use a syringe pump to continuously perfuse mineral oil into reservoir A at a flow rate of 800 nl / min; Perfuse with 0.1mol / L calcium nitrate solution. Liquid droplets of phosphorus precursor in oil (phosphorus precursor / mineral oil) are continuously formed at the first T-shaped channel 1, and flow along the channel through the second T-shaped channel 2 and calcium precursor driven by mineral oil. When the calcium precursor solution meets, through the three processes of collision, oil discharge, and oil film rupture, the calcium precursor solution enters the droplet, realizes fusion, and triggers a co-precipitation reaction. Figure 6 Micrographs of droplet formatio...

Embodiment 3

[0035] Droplet fusion and rapid mixing of different dyes as dispersed phases, using figure 1 The chip with the structure shown is shown in figure 2 . The syringe pump continuously perfuses mineral oil into reservoir A at a flow rate of 800nl / min, continuously perfuses 20mg / ml amaranth dye solution into the first reservoir at a flow rate of 500nl / min, and continuously perfuses the second reservoir with a flow rate of 300nl / min. Perfuse with 20mg / ml bromocresol blue dye solution. Droplets of the oil-in-amaranth solution (maranth / mineral oil) are continuously formed at the first-stage T-shaped channel 1, and the droplets flow along the channel through the second-stage T-shaped channel 2 under the driving of the mineral oil. When bromocresol blue solutions meet, through three processes of collision, oil discharge and oil film rupture, the bromocresol blue solution enters the droplets to achieve fusion. It can be seen from the observation that when the droplet moves in the curv...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a microfluidic chip based method for synthesizing needle-like hydroxyapatite (HAp) nanoparticles. The method employs monodisperse microfluidic droplet as a micro reactor, and utilizes a microfluidic chip droplet fusion as a core technology to realize HAp nanoparticle synthesis on a chip. The method has the following advantages: the droplet has small volume, and chaotic mixing has a rapid mass transfer speed; droplet is used as the micro reactor, and a product is output by continuous phase to diminish adsorption on passageway wall and agglomeration of nanoparticles; a PDMS chip is transparent, and easy for online real-time monitoring of material formation and control; and the design of the chip is simple, and easy for construction of multiple parallel reaction channels for high-throughput synthesis, so as to improve the yield of product.

Description

technical field [0001] The invention relates to a technology for synthesizing needle-like hydroxyapatite nanoparticles, and in particular provides a method for synthesizing needle-like hydroxyapatite nanoparticles based on a microfluidic chip. Background technique [0002] Hydroxyapatite (HAp for short) is a weakly alkaline calcium phosphate bioceramic material that is insoluble in water. It is the main component of natural bone, has good biocompatibility and bioactivity, can induce the formation of new bone and provide a scaffold for it; it can directly form a good osseointegration with bone tissue, and is an ideal hard tissue Replacement material. Due to its unique biological activity and compatibility, HAp has become a research hotspot in biomedical materials. The purpose of the research is to ensure that the material has a uniform morphology, narrow particle size distribution, good monodispersity and large surface area. Among them, uniform morphology and controllable ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C01B25/32B82Y40/00
Inventor 秦建华刘开颖
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap