Sea asparagus ferulic acid ester compound as well as preparation method and application of compound

A technology of pentadecyl ferulic acid and ferulic acid, applied in chemical instruments and methods, separation/purification of carboxylic acid esters, compositions for inhibiting chemical changes, etc. It is difficult to solve the problems of strong water-based antioxidant activity, etc., to achieve the effect of strong oxidative activity and strong free radical scavenging activity.

Active Publication Date: 2013-01-02
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that sodium ferulate and ferulic acid ester are the main derivatives of ferulic acid, and these two derivatives basically maintain the biological characteristics of ferulic acid, and the ferulic acid derivatives obtained through molecular modification Compared with ferulic acid, it has stronger physiological activity and lower toxicity. This is because the alkane in the ferulic acid molecule is shorter and contains double bonds, so it is difficult to penetrate deep into the lipid bilayer structure of the biomembrane to exert antioxidant properties. active
[0004] At present, some synthetic antioxidants such as di-tert-butyl p-cresol and tert-butyl hydroquinone will produce toxic substances and are carcinogenic.

Method used

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  • Sea asparagus ferulic acid ester compound as well as preparation method and application of compound
  • Sea asparagus ferulic acid ester compound as well as preparation method and application of compound
  • Sea asparagus ferulic acid ester compound as well as preparation method and application of compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 compound

[0022] 26.4kg of freshly picked sea asparagus was mashed with a homogenizer, placed in a 20L volumetric flask, added 8:2 acetone and water for extraction, left for 24 hours, and extracted three times. Suction filtration with a Buchner funnel, and the resulting solution was concentrated in vacuo at 30° C. with a rotary evaporator to obtain an acetone extract. Then, the acetone extract was extracted three times with ethyl acetate, and concentrated in vacuo at 30° C. with a rotary evaporator to obtain the ethyl acetate layer extract.

[0023] The ethyl acetate layer (71g) was mixed with 50g of silica gel in a dry method, then mounted on a normal-pressure column equipped with 200g of silica gel (300-400 mesh), and separated by petroleum ether-acetone-methanol gradient elution, that is, the elution of pure petroleum ether began. Gradually increase the proportion of acetone and decrease the proportion of petroleum ether until the el...

Embodiment 2

[0028] The test of embodiment 2 antioxidant activity

[0029] 1. Experimental samples and experimental methods

[0030] Preparation of positive reference substance: Weigh 0.1g of ascorbic acid, dissolve it in 100mL of distilled water to make a 1mg / mL solution, then pipette 0mL, 0.8mL, 1.6mL, 2.4mL, 3.2mL and 4.0mL into test tubes, and then Add 4mL, 3.2mL, 2.4mL, 1.6mL, 0.8mL and 0mL of distilled water to prepare the concentration of 0mg / mL, 0.2mg / mL, 0.4mg / mL, 0.6mg / mL, 0.8mg / mL and 1mg / mL Ascorbic acid solution.

[0031] Preparation of pentadecyl ferulic acid sample (named S6) solution: Take 10.0mg S 6 The sample (that is, the compound of formula (I) obtained in Example 1) was dissolved in 10 mL of distilled water to prepare a 1 mg / mL solution, and then pipette 0 mL, 0.8 mL, 1.6 mL, 2.4 mL, 3.2 mL and 4.0 mL into In the test tube, add distilled water 4.0mL, 3.2mL, 2.4mL, 1.6mL, 0.8mL and 0mL in sequence to make the concentration 0mg / mL, 0.2mg / mL, 0.4mg / mL, 0.6mg / mL, 0.8mg / ...

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Abstract

The invention belongs to the field of marine biotechnology, and discloses a sea asparagus ferulic acid ester compound as well as a preparation method and application of the compound. The sea asparagus ferulic acid ester compound is ferulic acid pentadecane ester which has the structural formula shown in a formula (I). The ferulic acid pentadecane ester separated out from sea asparagus is the compound obtained from natural resource for the first time, and has high oxidative activity and strong activity for removing free radicals, thus the sea asparagus ferulic acid ester compound can be used as a symbolic antioxidant active ingredient and a natural free-radical scavenger in the sea asparagus.

Description

technical field [0001] The invention belongs to the technical field of marine organisms, and relates to a sea asparagus ferulic acid ester compound, a preparation method and an application thereof. Background technique [0002] Salted sea asparagus is commonly known as salicornia or sea beans, and its scientific name is Salicornia bigelovii. It is a delicious, juicy, salty and crunchy green seawater vegetable. Studies have confirmed that sea asparagus lowers blood pressure and blood lipids, promotes the transformation of fat into muscle cells, promotes liver metabolism, improves human immunity and prevents Parkinson's disease. In vitro activity studies have shown that sea asparagus extract has significant antioxidant activity and antitumor activity. [0003] Ferulic acid is a phenolic acid ubiquitous in the plant kingdom. In plants, it is mainly cross-linked with cell wall polysaccharides and lignin to form a part of the cell wall. It is one of the active ingredients of tra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/734C07C67/48A61K31/216A61P39/06C09K15/08
Inventor 辛志宏王惠张敏赵育卉王晓敏
Owner NANJING AGRICULTURAL UNIVERSITY
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