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Preparation method of laminar nanometer hydroxylapatite with controllable pore diameter

A hydroxyapatite and layered nanotechnology, which is applied in the field of preparation of layered nano-hydroxyapatite, can solve the problems of wide pore size distribution, disordered mesoporous channels, and high cost, and achieves narrow pore size distribution and high production cost. Simple method and low cost of raw materials

Active Publication Date: 2013-01-09
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The template method is the main method to synthesize mesoporous hydroxyapatite, but because most of the templates used are not easy to degrade and are toxic, the removal of the template by calcination will lead to a decrease in the biological activity of the material and may cause the collapse of the pores, thus limiting this type of method. Applications of synthetic materials in living organisms
Although some mesoporous hydroxyapatite has good biocompatibility, there are problems such as disordered mesoporous channels, wide pore size distribution range, poor periodicity and uneven distribution.
The hydroxyapatite synthesized in the past can only synthesize pores of a certain size, it is difficult to control the size of the pores, and the synthesis process is complicated and the cost is high

Method used

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  • Preparation method of laminar nanometer hydroxylapatite with controllable pore diameter
  • Preparation method of laminar nanometer hydroxylapatite with controllable pore diameter
  • Preparation method of laminar nanometer hydroxylapatite with controllable pore diameter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1) Prepare 0.3mol / L calcium nitrate tetrahydrate solution and stir for 10 minutes;

[0016] 2) Dissolve 1.25g of potassium monododecyl phosphate in 15mL of water and 30mL of absolute ethanol, and stir for 15min;

[0017] 3) Manually add the potassium monododecyl phosphate solution into the calcium salt solution dropwise, and stir for 20 minutes;

[0018] 4) Prepare 0.05mol / L diammonium hydrogen phosphate solution, stir for 10 minutes, manually drop it into the above mixed solution, stir for 30 minutes, and form an emulsion;

[0019] 5) Use 6mol / L sodium hydroxide to adjust the pH of the emulsion to 10, continue stirring for 4 hours, and heat at 90°C for 10 hours;

[0020] 6) Washing and drying by centrifugation to obtain layered nano-hydroxyapatite.

Embodiment 2

[0022] 1) Prepare 0.45mol / L calcium nitrate tetrahydrate solution and stir for 10 minutes;

[0023] 2) Dissolve 2.5g of potassium monododecyl phosphate in 15mL of water and 30mL of absolute ethanol, and stir for 15min;

[0024] 3) Manually add the potassium monododecyl phosphate solution into the calcium salt solution dropwise, and stir for 25 minutes;

[0025] 4) Prepare 0.1mol / L diammonium hydrogen phosphate solution, stir for 10 minutes, manually drop it into the above mixed solution, stir for 30 minutes, and form an emulsion;

[0026] 5) Use 6mol / L sodium hydroxide to adjust the pH of the emulsion to 8, continue stirring for 4 hours, and heat at 90°C for 12 hours;

[0027] 6) Washing and drying by centrifugation to obtain layered nano-hydroxyapatite.

Embodiment 3

[0029] 1) Prepare 0.5mol / L calcium nitrate tetrahydrate solution and stir for 10 minutes;

[0030] 2) Dissolve 2.5g of sodium monododecyl phosphate in 15mL of water and 30mL of absolute ethanol, and stir for 15min;

[0031] 3) Manually add the sodium monododecyl phosphate solution into the calcium salt solution dropwise, and stir for 20 minutes;

[0032] 4) Prepare 0.08mol / L diammonium hydrogen phosphate solution, stir for 10 minutes, manually drop it into the above mixed solution, stir for 45 minutes to form an emulsion;

[0033] 5) Use 7mol / L sodium hydroxide to adjust the pH of the emulsion to 10, continue stirring for 4 hours, and heat at 90°C for 6 hours;

[0034] 6) Washing and drying by centrifugation to obtain layered nano-hydroxyapatite.

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Abstract

The invention discloses a preparation method of laminar nanometer hydroxylapatite with a controllable pore diameter. The laminar nanometer hydroxylapatite with ordered pore canals, narrow distribution range of pore diameter, high periodicity, high dispersity and controllable pore diameter is prepared by performing a hydro-thermal reaction on a soluble calcium salt and soluble phosphate or phosphoric acid, which serve as major raw materials, and monododecyl phosphate serving as a template agent. The preparation method disclosed by the invention is simple, is low in raw material cost, has a wide source, and is easy to popularize.

Description

technical field [0001] The invention belongs to the field of material preparation and nano-manufacturing, and in particular relates to a preparation method of layered nano-hydroxyapatite with controllable aperture. Background technique [0002] Hydroxyapatite is the main inorganic component of human bones and teeth. It has good biocompatibility. After implanted in the human body, it has no stimulation and rejection to human tissues. It is a good bone tissue repair material and drug release carrier. Due to the good thermal stability and low crystallization temperature of hydroxyapatite, the research on mesoporous hydroxyapatite has attracted more and more attention in recent years. The template method is the main method to synthesize mesoporous hydroxyapatite, but because most of the templates used are not easy to degrade and are toxic, the removal of the template by calcination will lead to a decrease in the biological activity of the material and may cause the collapse of t...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y40/00
Inventor 陈景帝杨沈张惠张其清
Owner FUZHOU UNIVERSITY
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