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Traditional Chinese medicine preparation for liver softening and preparation and detection methods of traditional Chinese medicine preparation
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The technology of a traditional Chinese medicine and a reference medicinal material is applied in the preparation and detection of the drug, the drug for symptoms, and the field of traditional Chinese medicine preparations for soft liver, which can solve the problems of complex production process, large toxic and side effects, and high recurrence rate, and achieve significant clinical efficacy and preparation technology. Simple, improved liver function
Inactive Publication Date: 2013-01-16
周岱翰
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Therefore, the surgical resection rate is less than 30% for patients who visit the doctor for the first time, and the postoperative recurrence rate of liver pain is as high as 47-82%.
目前已有一些中药制剂用于治疗肝癌的报道(CN1266703A、CN1552434A、CN1739771A、CN102091302A、CN102114136A、CN102441053A、CN101708272A、CN1679899A、CN102302663A、CN102188638A、CN101972448A、CN101559124A),但是仍存在不少问题:一是药物构成中 The amount of toxic drugs is large, so the side effects are relatively large; second, the drug ingredients are more, and the pharmacology is unclear; third, the production process is more complicated, the cost is higher, and it is not easy to control product quality
[0007] Zhou Daihan and others studied Shentao Ruangan Pills composed of ginseng and peach kernels (Shentao Ruangan Pills inhibit the proliferation of human livercancer cells and enhance the anti-tumor activity of LAK, Journal of Integrated Traditional Chinese and Western Medicine Liver Diseases, 2001, Volume 11, No. No. 1, 30-32; Experimental Study of Shentao Ruangan Pills on Hepatic Fibrosis in Rats, Journal of Traditional Chinese Medicine, April 2003, Volume 21, No. 4, 519-520; Shentao Ruangan Pills on Tumor Growth and the influence of T lymphocyte subsets, Journal of Cancer Prevention and Treatment, June 2002, Volume 9, No. 3, 241-243), and it has been verified by cell and animal experiments that it has a good therapeutic effect on liver cancer, but this The medicine also has the following deficiencies: one is that the effect is not stable enough; the other is that the production process level is low;
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[0102] 2. Preparation of reference substance solution Take an appropriate amount of chrysophanol reference substance, weigh it accurately, add methanol to make a solution containing 8ug of chrysophanol per 1mL, and get it;
[0103] 3. Take about 3g of the content of this product under the difference in loading amount, accurately weigh it, put it in a stoppered Erlenmeyer flask, add 50mL of methanol precisely, seal it tightly, weigh it, and ultrasonically treat it (power 250W, frequency 33kHz) for 30 Minutes, let cool, weigh again, make up the lost weight with methanol, shake well, filter, and take the filtrate to get final product;
[0104] 4. Determination method: Precisely draw 10uL each of the reference substance solution and the test solution, inject it into the liquid chromatograph, measure it, and get it;
[0105] 5. Each capsule of this pharmaceutical preparation contains raw rhubarb, calculated as chrysophanol (C15H1004), not less than 0.01mg.
[0106] (3) Concentrati...
Embodiment 1
[0129] 1. Prescription:
[0130] Sun-dried ginseng 1.5kg Angelica 1.5kg Salvia miltiorrhiza 1.5kg
[0131] Peach Kernel 1.5kg Agrimony 3.38kg Raw Rhubarb 1.5kg
[0134] A total of 10,000 capsules are made, each capsule is about 0.35g
[0135] 2. Properties: This product is a hard capsule, and the content is brown granules with a bitter taste.
[0136] Preparation method: the above eight flavors, raw sun-dried ginseng, salvia miltiorrhiza, and angelica were extracted with 7 times the amount of 75% alcohol for 2 times, each time for 1 hour, the extracts were filtered and combined, the recovered ethanol was concentrated to an appropriate amount, and the dregs and raw rhubarb were 3 times Combine and soak the flavor medicines for 0.5 hour, decoct 3 times, successively measure 9, 7, and 7 times of water, each time for 1.5 hours, filter, combine the combined filtrate and concent...
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technical field [0001] The invention belongs to the technical field of medicines, and relates to a medicine for treating symptoms such as ascites, jaundice, and hypochondriac pain caused by primary liver cancer, in particular a liver-softening traditional Chinese medicine preparation made from Chinese medicinal materials, and simultaneously relates to the preparation and preparation of the medicine. Detection method. Background technique [0002] Primary liver cancer (PLC) refers to cancer that occurs in liver cells or intrahepatic cholangiocytes, and is one of the most common and malignant tumors in the world. Its incidence rate ranks fifth in the world among malignant tumors, and its death rate ranks third. Nearly 200 million people in my country are infected with hepatitis B virus, and some of them will develop into liver cirrhosis and even liver cancer. Therefore, my country is an area with a high incidence of primary liver cancer, among which hepatocellular carcinoma a...
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