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Method for preparing a chitosan / aliphatic polyester amphiphilic graft copolymer

A technology of aliphatic polyester and graft copolymer, which is applied in the field of preparation of chitosan/aliphatic polyester amphiphilic graft copolymer, can solve problems such as poor repeatability and complicated experimental process, and achieve easy separation, The synthesis method is simple and the reaction conditions are mild

Inactive Publication Date: 2013-01-30
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its disadvantage is that there are a series of complex group protection and deprotection steps in the reaction, or surface chemical modification steps, which make the experimental process rather complicated and poorly reproducible

Method used

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  • Method for preparing a chitosan / aliphatic polyester amphiphilic graft copolymer
  • Method for preparing a chitosan / aliphatic polyester amphiphilic graft copolymer
  • Method for preparing a chitosan / aliphatic polyester amphiphilic graft copolymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the preparation of chitosan / polylactic acid amphiphilic graft copolymer

[0030] Weigh 0.05g of molecular weight to be 1.0×10 5 , Chitosan with a degree of deacetylation of 70% and 0.04 g of 1-hydroxybenzotriazole were dissolved in 10 mL of deionized water to obtain an aqueous phase. Weigh 3.0 g of polylactic acid with a molecular weight of 10,000 kDa and dissolve it in 30 mL of dichloromethane to prepare a solution with a concentration of 100 g / L to obtain an oil phase. After the polylactic acid is completely dissolved, add 0.6g emulsifier Span 80 and 0.17g condensing agent EDC. In the state of stirring, the chitosan solution of the water phase is added dropwise into the oil phase to obtain the water-in-oil type mixed emulsion. The mixed emulsion was placed in a homogenizer for high-speed emulsification and dispersion at 10,000 rpm for 3 minutes, and then placed on a magnetic stirrer at room temperature to continue the reaction for 12 hours. After the ...

Embodiment 2

[0031] Embodiment 2: the preparation of chitosan / polylactic acid amphiphilic graft copolymer

[0032] Weigh 0.05g of molecular weight to be 1.0×10 5 1. Chitosan with a degree of deacetylation of 85% and 0.04 g of 1-hydroxybenzotriazole were dissolved in 10 mL of deionized water to obtain an aqueous phase. Weigh 3.0 g of polylactic acid with a molecular weight of 5,000 kDa and dissolve it in 30 mL of chloroform to prepare a solution with a concentration of 100 g / L to obtain an oil phase. After the polylactic acid is completely dissolved, add 0.6g emulsifier Span 80 and 0.17g condensing agent EDC. In the state of stirring, the chitosan solution of the water phase is added dropwise into the oil phase to obtain the water-in-oil type mixed emulsion. The mixed emulsion was placed in a homogenizer for high-speed emulsification and dispersion at 10,000 rpm for 5 minutes, and then placed on a magnetic stirrer at room temperature for 24 hours. After the reaction was completed, the em...

Embodiment 3

[0033]Embodiment 3: the preparation of chitosan / polyglycolic acid amphiphilic graft copolymer

[0034] Weigh 0.05g of molecular weight to be 1.0×10 5 , Chitosan with a degree of deacetylation of 70% and 0.04 g of 1-hydroxybenzotriazole were dissolved in 10 mL of deionized water to obtain an aqueous phase. Weigh 3.0 g of polyglycolic acid with a molecular weight of 10,000 kDa and dissolve it in 30 mL of dichloromethane to prepare a solution with a concentration of 100 g L to obtain an oil phase. After the polyglycolic acid is completely dissolved, add 0.6g emulsifier Span 80 and 0.17g condensing agent EDC. In the state of stirring, the chitosan solution of the water phase is added dropwise into the oil phase to obtain the water-in-oil type mixed emulsion. The mixed emulsion was placed in a homogenizer for high-speed emulsification and dispersion at 10,000 rpm for 3 minutes, and then placed on a magnetic stirrer at room temperature to continue the reaction for 12 hours. After...

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Abstract

The invention discloses a method for preparing a chitosan / aliphatic polyester amphiphilic graft copolymer, and belongs to the technical field of biomedical materials. The method employs an emulsion self-assembly synthesis principle that first a hydrophilic chitosan solution and a hydrophobic aliphatic polyester solution are mixed according to different ratios under the action of a surfactant, so as to prepare a water-in-oil mixed emulsion; and further a principle that a condensating agent carbodiimide activates carboxyl group is used, so that the chitosan and polyester in the mixed emulsion conduct an intermolecular self-assembly reaction to form the chitosan / aliphatic polyester amphiphilic graft copolymer. A novel biological medicinal material obtained by the invention has good hydrophilicity and cell affinity as an extracellular matrix glycan material, and has good mechanical properties and machinability as an aliphatic polyester material, and is hopefully to be widely applied to the fields of drug controlled release and tissue defect repair.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, more precisely, the invention relates to a preparation method of a chitosan / aliphatic polyester amphiphilic graft copolymer. Background technique [0002] Biomedical materials are an important part of tissue engineering and tissue regeneration and repair, and are also one of the most critical factors affecting tissue construction. In order to obtain better biomedical materials, various material design strategies have been proposed, one of which is to use bioactive substances that can be degraded and metabolized in vivo to modify polymer materials (Narayan R, Balakrishnan S, Nabar Y, et al. Starch-polyester biodegradable graft copolymers and a method of preparation thereof. US 7629405B2, 2009; Chen Mingqing, Ni Zhongbin, Yang Wei, etc. A kind of hydrophilic-hydrophobic copolymer with controllable main and side chain length Preparation method of graft polymer. CN 100418992C, 2008). I...

Claims

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Application Information

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IPC IPC(8): C08G81/00C08G63/91C08B37/08A61K47/34A61L27/20A61L27/50
Inventor 牛旭锋樊瑜波李晓明李萍周钢陈品
Owner BEIHANG UNIV
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