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Traditional Chinese medicine chewable tablet for treating upper respiratory tract infection and preparation method of chewable tablet

An upper respiratory tract and chewable tablet technology, applied in the field of traditional Chinese medicine, can solve problems such as poor stability, and achieve the effects of rapid absorption, good reproducibility and good taste

Inactive Publication Date: 2013-02-27
CHONGQING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, considering that the traditional Chinese medicine Scutellaria baicalensis and Gardenia Fructus all have bitter taste, and the stability of baicalin in aqueous solution is relatively poor, so the present invention makes it into a solid dosage form, and by adding suitable adjuvants, the bitter taste of the medicine is covered to make up for the decoction, Insufficient oral fluid

Method used

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  • Traditional Chinese medicine chewable tablet for treating upper respiratory tract infection and preparation method of chewable tablet
  • Traditional Chinese medicine chewable tablet for treating upper respiratory tract infection and preparation method of chewable tablet
  • Traditional Chinese medicine chewable tablet for treating upper respiratory tract infection and preparation method of chewable tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] 【formula】

[0141]

[0142] The crude drug and pharmaceutical adjuvant of above-mentioned weight are made into 1000 Chinese medicine chewable tablets altogether.

[0143] [Preparation method] Dissolve Scutellaria baicalensis extract and Gardenia jasmine extract with appropriate amount of ethanol; prepare β-cyclodextrin saturated aqueous solution at 80°C; slowly add drug raw material ethanol solution to β-cyclodextrin saturated solution under stirring condition In the aqueous solution, stir at constant temperature for 1 hour, stop heating, and continue to stir to room temperature to obtain a white suspension, refrigerate for 72 hours, filter with suction, wash the precipitate twice with ethanol, dry under reduced pressure at 60°C, and pulverize; lactose, xylose Alcohol, mannitol, soluble starch and sodium carboxymethyl cellulose are mixed evenly, add the clathrate of drug raw materials, mix well, make soft material with 15% polyvinylpyrrolidone and 80% ethanol solutio...

Embodiment 2

[0163] 【formula】

[0164]

[0165]

[0166] The crude drug and pharmaceutical adjuvant of above-mentioned weight are made into 1000 Chinese medicine chewable tablets altogether.

[0167] [Preparation method] Dissolve Scutellaria baicalensis extract and Gardenia jasmine extract with appropriate amount of ethanol; prepare β-cyclodextrin saturated aqueous solution at 80°C; slowly add drug raw material ethanol solution into β-cyclodextrin saturated solution under stirring condition In the aqueous solution, stir at constant temperature for 1.5 hours, stop heating, continue to stir to room temperature, and obtain a white suspension, refrigerate for 84 hours, filter with suction, wash the precipitate with ethanol three times, dry under reduced pressure at 50°C, and pulverize; lactose, xylose Alcohol, mannitol, soluble starch and sodium carboxymethyl cellulose are mixed evenly, add the clathrate of drug raw materials, mix well, make soft material with 20% polyvinylpyrrolidone an...

Embodiment 3

[0184] 【formula】

[0185]

[0186] The crude drug and pharmaceutical adjuvant of above-mentioned weight are made into 1000 Chinese medicine chewable tablets altogether.

[0187] [Preparation method] Dissolve Scutellaria baicalensis extract and Gardenia jasmine extract with appropriate amount of ethanol; prepare β-cyclodextrin saturated aqueous solution at 80°C; slowly add drug raw material ethanol solution to β-cyclodextrin saturated solution under stirring condition In the aqueous solution, stir at constant temperature for 2 hours, stop heating, and continue to stir to room temperature to obtain a white suspension, refrigerate for 96 hours, filter with suction, wash the precipitate with ethanol 4 times, dry under reduced pressure at 40°C, and pulverize; lactose, xylose Alcohol, mannitol, soluble starch and sodium carboxymethyl cellulose are mixed evenly, add the clathrate of drug raw materials, mix well, make soft material with 25% polyvinylpyrrolidone and 60% ethanol solu...

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Abstract

The invention discloses a traditional Chinese medicine chewable tablet for treating upper respiratory tract infection and a preparation method of the chewable tablet. The traditional Chinese medicine chewable tablet is a solid preparation prepared from radix scutellariae extractive, jasmine extractive and medical additives according to proper proportions and proper procedures; and the traditional Chinese medicine chewable tablet can not only effectively resist against virus and sterilize, but also has such functions as clearing heat, anti-inflammatory and analgesia, etc. Compared with the common tablets, the traditional Chinese medicine chewable tablet disclosed by the invention has the advantages of good taste, quick absorption, fast effect taking, strong action, good compliance and the like, is convenient to take, and is especially suitable for elders, children and swallowing difficulty patients. The invention further discloses a quality detecting method of the traditional Chinese medicine chewable tablet. The quality detecting method comprises verifying, checking and content measuring procedures. The precision of the quality control method is high, the reproducibility is good, the recovery is high, the preparation quality can be effectively guaranteed, and the clinic treatment effect is fully guaranteed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine chewable tablet for treating upper respiratory tract infection and its preparation and quality testing methods, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Upper respiratory tract infection is the general term for nose, pharynx and laryngitis, commonly known as "cold" and "cold". It is a common and frequently-occurring disease that has a great impact on people's life, study and work. Sore throat, cough, runny nose, sneezing, body aches and swollen tonsils. [0003] Modern medicine believes that the disease is caused by bacterial or viral infection, and the infection caused by viruses and bacteria together accounts for about 90%. If it is not treated in time, it may be combined or secondary to a variety of serious infections, and even threaten humans (especially children and the elderly) s life. Western medicine is mainly based on symptomatic t...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K36/539A61K9/20A61P11/00A61P31/04A61P31/12A61P29/00G01N30/90G01N30/02
Inventor 姚干何宗玉
Owner CHONGQING UNIV OF POSTS & TELECOMM
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