Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of nano-hydroxyapatite/chitosan

A nano-hydroxyapatite and chitosan technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve problems such as lack, and achieve the effects of regular morphology, simple preparation process and good crystallinity

Inactive Publication Date: 2013-03-20
JIANGNAN UNIV
View PDF1 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is still a lack of a convenient preparation method for the successful preparation of nano-hydroxyapatite / chitosan composite materials with particle width and long diameter at the nanoscale by using the inverse microemulsion method. Expanding the application prospect of nano-hydroxyapatite / chitosan composites in the field of biomedicine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of nano-hydroxyapatite/chitosan
  • Preparation method of nano-hydroxyapatite/chitosan
  • Preparation method of nano-hydroxyapatite/chitosan

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment one: a kind of preparation method of nano-hydroxyapatite / chitosan, comprises the following processing steps:

[0023] (1) Synthesis of nano-hydroxyapatite: Mix sodium phosphate solution, calcium chloride solution and cetyltrimethylammonium bromide solution (CTAB) to obtain a reaction system, in which Ca 2+ The ion concentration is 0.08mmol·L -1 , the concentration of phosphate ion is 0.048mmol·L -1 , the concentration of CTAB is 8×10 -4 mol L -1 , and the molar ratio of calcium ions to phosphate ions is 5:3; react for 12 to 96 hours, and adjust the pH value to remain at 8; filter the obtained product through a 0.22 μm microporous membrane after being centrifuged in a centrifuge, and The filtered solid was alternately washed twice with water and absolute ethanol, and then vacuum-dried overnight at 30°C to obtain nano-hydroxyapatite powder;

[0024] (2) Dissolve 0.05g of chitosan powder in 5mL of 1% acetic acid aqueous solution to obtain a chitosan solution...

Embodiment 2

[0029] Embodiment two: a kind of preparation method of nano-hydroxyapatite / chitosan, comprises the following processing steps:

[0030] (1) Synthesis of nano-hydroxyapatite: Mix sodium hydrogen phosphate solution, calcium chloride solution and cetyltrimethylammonium bromide solution (CTAB) to obtain a reaction system, in which Ca 2+ The ion concentration is 500mmol·L -1 , the concentration of phosphate ion is 300mmol·L -1 , the concentration of CTAB is 10.5×10 -4 mol L -1 , and the molar ratio of calcium ions to phosphate ions is 5:3; react for 96 hours, and adjust the pH value to remain at 14; filter the obtained product through a 0.22 μm microporous membrane after centrifugation, and filter to obtain The solid was alternately washed 20 times with water and absolute ethanol, and then dried in vacuum at 80°C overnight to obtain nano-hydroxyapatite powder;

[0031] (2) Dissolve 1.5g of chitosan powder in 500mL of 5% acetic acid aqueous solution to obtain a chitosan solution...

Embodiment 3

[0033] Embodiment three: a kind of preparation method of nano-hydroxyapatite / chitosan, comprises the following processing steps:

[0034] (1) Synthesis of nano-hydroxyapatite: Mix sodium dihydrogen phosphate solution, calcium chloride solution and cetyltrimethylammonium bromide solution (CTAB) to obtain a reaction system, in which Ca 2+ The ion concentration is 10 mmol L -1 , the concentration of phosphate ion is 6 mmol·L -1 , the concentration of CTAB is 9×10 -4 mol L -1 , and the molar ratio of calcium ions to phosphate ions is 5:3; react for 36 hours, and adjust the pH value to maintain at 10; filter the obtained product through a 0.22 μm microporous membrane after centrifugation, and filter to obtain The solid was alternately washed 10 times with water and absolute ethanol, and then dried under vacuum at 50°C overnight to obtain nano-hydroxyapatite powder;

[0035] (2) Dissolve 1g of chitosan powder in 250mL of 2% acetic acid aqueous solution to obtain a chitosan solu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Widthaaaaaaaaaa
Lengthaaaaaaaaaa
Widthaaaaaaaaaa
Login to View More

Abstract

The invention relates to a preparation method of a nano-hydroxyapatite / chitosan composite material. The preparation method comprises the following steps of: uniformly mixing nano-hydroxyapatite with an acetic acid solution of chitosan, mixing a mixture with liquid paraffin, adding an emulsifying agent span80 (sorbitan oleate); after a system is fully emulsified, adding glutaraldehyde for carrying out crosslinking reaction; and centrifugally separating, washing and vacuum-drying a suspension and then collecting to obtain the nano-hydroxyapatite / chitosan composite material. According to the reversed-phase microemulsion preparation method of the nano-hydroxyapatite / chitosan composite material, provided by the invention, the nano-hydroxyapatite / chitosan composite material has the characteristics of particle width and long diameter within a nano scale range, regular feature and good crystallinity. The preparation method is simple in preparation process and low in cost, is suitable for batch production, and has an important application value in the field of biomedicine.

Description

technical field [0001] The invention relates to a preparation method of nano-hydroxyapatite / chitosan, belonging to the technical field of inorganic nano-materials. Background technique [0002] Nano-hydroxyapatite (n-HA) has good biocompatibility and bioactivity, and is widely used in bone tissue repair and replacement technology, but the material is too brittle, which limits its use in bone replacement and Application in bone repair. Chitosan (CS) is a polysaccharide with cations after deacetylation of chitin, which is naturally degradable, non-toxic, harmless, non-irritating to the human body and tissues, and has good biocompatibility. Adhesion and proliferation have many excellent properties such as promoting effect. If n-HA and CS are made into a composite material, the new material is expected to improve its mechanical properties in addition to its excellent biocompatibility, so there is a large room for development in the field of bone substitute materials. The rese...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08J3/24C08J3/07C08L5/08C08K3/32C01B25/32
CPCC01B25/32C08J3/24C08L5/08C08K3/32C08J3/07C08J3/205C08J2305/08C08K2003/325C08K2201/011
Inventor 李玲董燕超方云王方育
Owner JIANGNAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com