A Moist Antibacterial Hydrogel Dressing for Diabetic Foot Ulcer

A technology for diabetic foot ulcers and hydrogels, which is used in medical science, bandages, absorbent pads, etc., can solve the problems of pain, frequent, once a day or every other day, and psychological pressure of patients, and achieves absorption of wound exudate, Accelerates wound healing and is easy to operate

Active Publication Date: 2014-10-01
钟春燕
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The general wound treatment method uses traditional dressings, mainly gauze, cotton pads, wiping with iodophor, wet compressing with normal saline and using oily gauze or traditional Chinese medicine ointment, etc., the curative effect is not good
However, these methods require frequent dressing changes, once a day or every other day, and twice a day when there is a lot of exudate.
Frequent dressing changes are not conducive to skin epithelialization and wound healing, and also bring pain and psychological pressure to patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Sodium alginate is dissolved in twice-distilled water to obtain a sodium alginate aqueous solution with a weight percentage of sodium alginate of 1%. Dissolve silver nitrate in sodium alginate aqueous solution, wherein the molar percentage of silver ions is 0.01mol / L. Sodium borohydride is used as a reducing agent, and gradually added dropwise into an aqueous sodium alginate solution containing silver ions to obtain a nano-silver sodium alginate solution.

[0022] 2. Immerse the separated and purified bacterial cellulose film produced by Acetobacter xylinum in the nano-silver sodium alginate solution for 20 minutes, and freeze-dry to obtain the bacterial cellulose / nano-silver sodium alginate composite film. Immerse the composite film in an aqueous solution of calcium chloride containing 1% calcium chloride by weight for 5 minutes, and finally obtain a wet antibacterial hydrogel dressing that can treat diabetic foot ulcers. The dressing is bacterial cellulose hydrogel...

Embodiment 2

[0024] 1. Sodium alginate is dissolved in double distilled water to obtain a sodium alginate aqueous solution with a weight percentage of sodium alginate of 2%. Dissolve silver sulfate in sodium alginate aqueous solution, wherein the molar percentage of silver ions is 0.05mol / L. Sodium citrate is used as a reducing agent, and gradually added dropwise into an aqueous solution of sodium alginate containing silver ions to obtain a nano-silver sodium alginate solution.

[0025]2. Immerse the separated and purified bacterial cellulose film produced by Rhizobium in the nano-silver sodium alginate solution for 180 minutes, and freeze-dry to obtain the bacterial cellulose / nano-silver sodium alginate composite film. Immerse the composite film in an aqueous solution of calcium chloride containing 2% calcium chloride by weight for 20 minutes, and finally obtain a wet antibacterial hydrogel dressing that can treat diabetic foot ulcers. The dressing is bacterial cellulose hydrogel A compo...

Embodiment 3

[0027] 1. Sodium alginate is dissolved in double distilled water to obtain a sodium alginate aqueous solution with a weight percentage of sodium alginate of 3%. Dissolve silver phosphate in sodium alginate aqueous solution, wherein the molar percentage of silver ions is 0.1mol / L. Vitamin C is used as a reducing agent, and is gradually added dropwise into an aqueous solution of sodium alginate containing silver ions to obtain a nano-silver sodium alginate solution.

[0028] 2. Immerse the separated and purified bacterial cellulose film produced by Sarcina in the nano-silver sodium alginate solution for 30 minutes, and freeze-dry to obtain the bacterial cellulose / nano-silver sodium alginate composite film. Immerse the composite film in an aqueous solution of calcium chloride containing 5% calcium chloride by weight for 60 minutes, and finally obtain a wet antibacterial hydrogel dressing that can treat diabetic foot ulcers. The dressing is bacterial cellulose hydrogel A composit...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a moist antibacterial hydrogel dressing for curing diabetic foot ulcer, and relates to the technical field of medical instruments and preparation thereof. The dressing is prepared by the following steps: dissolving ionic compounds in sodium alga acid water solution, and obtaining nano-silver sodium alga acid solution through adding reducing agent; adopting the impregnation method, placing the nano-silver sodium alga acid solution in a bacterial cellulose membrane, so as to obtain bacterial cellulose / nano-silver sodium alga acid composite membrane through freeze drying; and immersing the composite membrane in calcium chloride water solution, and obtaining the moist antibacterial hydrogel dressing for curing diabetic foot ulcer. The dressing is a composite hydrogel membrane including bacterial cellulose hydrogel and nano-silver contained calcium alginatehydrogel. The preparation is convenient to operate and low in cost, and the moist antibacterial hydrogel dressing prepared for curing diabetic foot ulcer has the performances of sterilizing, preserving moisture, absorbing wound percolate, quickening wound healing and the like, and is applied to curing wound traumas of diabetic foot ulcer, venous ulcer, pressure sores and donor site wounds at the lower limbs.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a method for preparing a wet antibacterial hydrogel dressing for treating diabetic foot ulcers. Background technique [0002] Diabetic foot refers to infection, ulceration and / or deep tissue destruction of the foot (at or below the ankle) associated with distal neurological abnormalities and varying degrees of peripheral vascular disease in the lower extremities, mainly manifested as foot ulcers and gangrene. Diabetic foot is one of the main causes of disability in diabetic patients. 15% to 20% of diabetic patients develop foot ulcers or gangrene during the course of the disease, and the amputation rate of diabetic foot disease is 15 to 20 times that of non-diabetic patients. About 50% of non-traumatic amputations per year are diabetic patients. Once diabetic foot is diagnosed, on the basis of systemic treatment that removes the cause, strictly cont...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/44
Inventor 钟春燕其他发明人请求不公开姓名
Owner 钟春燕
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products