Novel hydrogel scar patch and its preparation process

A preparation process and hydrogel technology, applied in the field of medical cosmetology, can solve the problems of weak hydration, easy adhesion of microorganisms, microbial growth, etc., and achieve a high degree of hydration, good biocompatibility, and high drug concentration. Effect

Active Publication Date: 2013-05-08
HANGZHOU JUJIU SCI & BIOTECHNOLOGY CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the above-mentioned silicone gel scar stickers have the following problems: 1. Weak hydration: First, this type of product does not contain moisture, and its hydration is blocked by silicone gel products through skin moisture evaporation, and the moisture is passive. Retained in the scar skin, the hydration effect is limited; secondly, due to some serious injuries, such as third-degree burns, skin sweat glands, etc., the water evaporation is limited, and the hydration effect is greatly weakened; 2. Lack of protective function for the scar body: For scars, especially severe hypertrophic scars and keloids, the skin on the surface is often damaged, and there may be tiny cracks or microbial infections, while silicone gel products lack antibacterial or bactericidal functions, and because such products are applied to scars Due to the relatively high humidity and temperature, it is easy to cause the growth of microorganisms and cause inflammation of the scar; 3. Repeated use will affect the sanitation and hydration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A new type of hydrogel scar patch is made by the following method: dissolve various raw materials of the hydrogel matrix in the glycerin phase and the water phase respectively according to various characteristics, and stir them evenly; characteristics, add glycerin or water phase respectively, and stir evenly; remove the air bubbles in the glycerin phase and water phase in a vacuum state, and stir evenly to obtain the hydrogel matrix, which is ready for use; the hydrogel matrix containing the drug is coated with Cloth machine, coating on the support layer, covering the isolation film on the other side of the hydrogel, cutting according to certain specifications, bagging and sealing, and the hydrogel scar patch is obtained.

Embodiment 2

[0029] 1. Its preparation process is as follows:

[0030] 1) Take 4~8.5% polyacrylic acid resin, 0.1~1.5% sodium carboxymethyl cellulose, 0.03~0.3% crosslinking agent, 0.02~0.3% EDTA, 0.05~1% antibacterial agent according to the formula ratio, and mix the above ingredients Disperse in 20~30% humectant and mix well in turn to get liquid A;

[0031] 2) Take 0.01~0.5% polyvinylpyrrolidone according to the proportion of the formula, disperse it in an appropriate amount of deionized water and stir evenly, then spread 0.4~3% carbomer on the liquid surface, let it stand for swelling for 12~24 hours, and then stir evenly for later use , and finally add 0.1~1% polyvinyl alcohol to suitable water and heat to dissolve, after cooling, mix and stir with the former, add the rest of deionized water, stir evenly, and obtain liquid B;

[0032] 3) 1-20% of the drug, according to its drug characteristics, if it is fat-soluble, put it in liquid A and mix evenly; Can;

[0033] 4) Add the pre-pr...

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PUM

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Abstract

The invention relates to a novel hydrogel scar patch and its preparation process. The hydrogel scar patch is composed of a support layer, a hydrogel layer and an isolation layer. The scar patch is characterized in that the hydrogel layer consists of the following components by mass: 0.4-3% of a water-soluble high polymer compound Carbomer, 4-8.5% of polyacrylic acid resin, 0.1-1% of polyvinyl alcohol, 0.1-2% of sodium carboxymethyl cellulose, 0.01-0.5% of polyvinyl pyrrolidone, 20-30% of a moisturizing agent, 0.03-0.3% of a cross-linking agent, 0.02-0.3% of EDTA, 0.05-1% of a bacteriostatic agent, 50-70% of deionized water, a proper amount of a pH conditioning agent, and 1-20% of a drug.

Description

technical field [0001] The invention relates to the field of medical cosmetology, in particular to an external skin preparation applied to soften various scars on the skin surface, inhibit hyperplasia, flatten, relieve itching and fade. Background technique [0002] Scars are the inevitable result of healing of various wounds, but if the healing is insufficient or excessive, scars will be formed, and if the scars continue to proliferate, hypertrophic scars can occur. According to the degree of damage caused by various injury factors and the physique of the injured, the following types of scars can be caused: superficial scars, atrophic scars, sunken scars, hypertrophic scars, keloids, especially for people with scar constitution, scars Especially obvious. Scars will bring great inconvenience to patients, such as hypertrophic scars caused by burns, which can cause local itching, pain, and even dysfunction, which seriously troubles patients. The prevention and treatment of s...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K36/896A61L31/16A61L31/04A61P17/02A61K31/045A61K31/203A61K31/573A61K31/616A61K31/722A61K31/728A61K31/80
Inventor 舒朝锋俞瑞珺
Owner HANGZHOU JUJIU SCI & BIOTECHNOLOGY CO
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