Application of iIllicium macranthum alcohol in preparation of medicine for treating depression

A kind of octagonal alcohol and anti-depression technology, applied in the field of medicine, can solve the problems of easy recurrence, high price, poor tolerance, etc., achieve good anti-depressant effect, high safety, and widen the effect of source

Active Publication Date: 2013-05-08
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In terms of drug treatment for depression, chemically synthesized antidepressants have always dominated the mainstream psychiatric field, but their side effects are always worrying, such as the toxic side effects of tricyclic antidepressants on the heart, and the side effects caused by other chemical drugs. Unresolved issues such as weight change and sexual dysfunction
Traditional heterocyclic antidepressants have a narrow therapeutic index and poor tolerance, which affect drug efficacy and patient compliance; new antidepressants such as selective serotonin reuptake inhibitors have relatively fewer side effects and better tolerance, but more expensive
Due to the complex pathogenesis of depression and many causes, it is often difficult for drugs targeting a single link to achieve satisfactory curative effect. In addition, most synthetic antidepressants have defects such as narrow antidepressant spectrum, large side effects, high drug price and easy recurrence. Therefore, the superiority of natural medicines in the treatment of depression is increasingly attracting the attention of scholars at home and abroad.
[0008] At present, there is no relevant literature report on the antidepressant effect of octagonal alcohol

Method used

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  • Application of iIllicium macranthum alcohol in preparation of medicine for treating depression
  • Application of iIllicium macranthum alcohol in preparation of medicine for treating depression
  • Application of iIllicium macranthum alcohol in preparation of medicine for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Alcohol Extraction Chromatography Extraction and Separation of Octagonal Alcohol

[0034] 3.5kg of safflower star anise (Illicium dunianum Tutch) was pulverized into powder; 95% ethanol was used as the extraction solvent, refluxed at 60°C for 2 hours, and the solvent was recovered to obtain its ethanol extract; after that, the obtained ethanol extract was dissolved with petroleum ether, and Separation by silica gel column chromatography, and gradient elution with petroleum ether-ethyl acetate system, a total of 16 components were eluted; : 3), ODS (methanol: water=3: 7) column chromatographic purification, can obtain big flower octagonal alcohol (374mg).

Embodiment 2

[0035] Embodiment 2 mouse forced swimming test

[0036] 2.1 Experimental animals Male ICR mice were purchased from the Experimental Animal Center of Fujian University of Traditional Chinese Medicine, weighing 22-26g, and the license number is SCXK (Fujian) 2010-0001; the animals were placed in cages of 320×180×160cm, 8 per cage , the mice acclimatized to the environment for one week; during the whole experiment, the mice were given free access to water and food, the ambient temperature was 22±2°C, the relative humidity was 55±5%, and the light was 12 hours a day (7:00 am to 7:00 pm).

[0037]2.2 Drug configuration The positive drug imipramine hydrochloride (IMI) was purchased from Sigma-Aldrich Company, and it was formulated into a 15mg / 10ml liquid medicine with normal saline as a solvent; / ml, 20mg / ml, 40mg / ml three doses of liquid medicine.

[0038] 2.3 Animal grouping and administration method 40 mice were divided into 5 groups, 8 in each group, respectively the model cont...

Embodiment 3

[0042] Embodiment 3 mouse tail suspension test

[0043] 3.1 Experimental animals Male ICR mice were purchased from the Experimental Animal Center of Fujian University of Traditional Chinese Medicine, weighing 22-26g, and the license number is SCXK (Fujian) 2010-0001; the animals were placed in cages of 320×180×160cm, 8 per cage , the mice acclimatized to the environment for one week; during the whole experiment, the mice were given free access to water and food, the ambient temperature was 22±2°C, the relative humidity was 55±5%, and the light was 12 hours a day (7:00 am to 7:00 pm).

[0044] 3.2 Drug configuration The positive drug imipramine hydrochloride (IMI) was purchased from Sigma-Aldrich Company, and it was configured into a 15mg / 10ml liquid medicine with normal saline as a solvent; ml, 20mg / ml, 40mg / ml three doses of liquid medicine.

[0045] 3.3 Animal grouping and administration method 40 mice were divided into 5 groups, 8 in each group, respectively the model cont...

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Abstract

The invention provides application of illicium macranthum alcohol in preparation of a medicine for treating depression and belongs to the technical field of medicines. The illicium macranthum alcohol has the characteristics of wide source and low cost; the illicium macranthum alcohol serves as a natural medicine, serves as a traditional medicine to be durably used, namely the illicium macranthum alcohol serves as a medicine and has high using safety; and moreover, the illicium macranthum alcohol has a good depression treatment effect, so that the illicium macranthum alcohol can serve as a depression treatment medicine or a related lead compound and is used for pharmaceutical production, and the source of the natural depression treatment medicines is widened.

Description

【Technical field】 [0001] The invention relates to the technical field of medicines, in particular to the application of octagonal alcohol in the preparation of antidepressant drugs. 【Background technique】 [0002] Macranthol (see formula 1 for its chemical structure), molecular formula C27H26O3, molecular weight 398, CAS: 123941-73-1. [0003] [0004] Formula 1 [0005] Octagonal alcohol is a lignin compound isolated from the bark of the star anise plant. At present, there are few reports on its pharmacological effects, and it is only found that it has the effect of protecting neurons (Moriyama M, Huang JM, Yang C S, et al. Bull. 2008;56:1201-4.). After literature search, no research report on the biological activity of this compound in antidepressant has been found so far. [0006] Depression includes unipolar depression, adjustment disorder, postpartum depression, seasonal affective disorder, bipolar disorder or bipolar disorder, etc. Serious disease of endocrine ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P25/24
Inventor 易立涛耿頔翁连进李晶
Owner HUAQIAO UNIVERSITY
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