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Traditional Chinese medicine composition and preparation method and application thereof

A technology of composition and traditional Chinese medicine, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve problems such as adverse reactions, failure of sulfonylurea drugs, drug failure, etc., to promote pancreatic function, lower blood sugar levels, and prevent and treat complications. Effect

Active Publication Date: 2013-05-15
HILL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The hypoglycemic effect of chemical drugs is obvious, but long-term use is prone to adverse reactions, inducing various complications, and sometimes drug failure, sulfonylureas secondary failure

Method used

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  • Traditional Chinese medicine composition and preparation method and application thereof
  • Traditional Chinese medicine composition and preparation method and application thereof
  • Traditional Chinese medicine composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Weighing: 6 parts of mulberry white skin, 3 parts of fenugreek seeds, 3 parts of Coptis chinensis

[0049] Mix the above-mentioned raw materials by weight, add 10 times the weight of water, soak for 30 minutes, boil for 30 minutes, take out and retain the filtrate; add 8 times the weight of water to the filter residue, soak for 20 minutes, boil for 20 minutes, The filtrate was retained; the 2 filtrates were combined and concentrated to a relative density of 1.05.

[0050] After the filtrate is allowed to cool, first add lime milk with a mass concentration of 30%, shake well, shake well, then add ethanol for precipitation, so that the final concentration of ethanol is 50%, centrifuge, and take the supernatant;

[0051] The pH of the supernatant was adjusted to 3.0, and after the precipitation was removed, it was adsorbed by macroporous cation exchange resin or gel cation exchange resin. After washing with water to remove impurities, the resin was eluted with ammonia wate...

Embodiment 2

[0053] Weighing: 6 parts of mulberry white skin, 3 parts of fenugreek seeds, 3 parts of Coptis chinensis

[0054] Mix the above-mentioned raw materials by weight evenly, add 10 times the weight of water, soak for 20-30 minutes, boil for 20-30 minutes, take out and retain the filtrate; add 8 times the weight of water to the filter residue, soak for 20-30 minutes. minutes, boil for 20-30 minutes, and keep the filtrate; combine the 2 filtrates and concentrate to a relative density of 1.15.

[0055] After the filtrate is allowed to cool, first add lime milk with a mass concentration of 25%, shake well, shake well, then add ethanol for precipitation, so that the final concentration of ethanol is 60%, centrifuge, and take the supernatant;

[0056] The pH of the supernatant was adjusted to 4.0, and after the precipitation was removed, it was adsorbed by macroporous cation exchange resin or gel cation exchange resin. After washing with water to remove impurities, the resin was eluted ...

Embodiment 3

[0058] Weighing: 6 parts of mulberry white skin, 3 parts of fenugreek seeds, 3 parts of Coptis chinensis

[0059] Mix the above-mentioned raw materials by weight evenly, add 10 times the weight of water, soak for 20-30 minutes, boil for 20-30 minutes, take out and retain the filtrate; add 8 times the weight of water to the filter residue, soak for 20-30 minutes. minutes, boil for 20-30 minutes, keep the filtrate; combine the 2 filtrates and concentrate to a relative density of 1.10.

[0060] After the filtrate is allowed to cool, first add lime milk with a mass concentration of 15%, shake well, shake well, then add ethanol for precipitation, so that the final concentration of ethanol is 55%, centrifuge, and take the supernatant;

[0061] The supernatant was adjusted to pH 3.0, adsorbed by macroporous cation-exchange resin or gel-type cation-exchange resin after removal of precipitation, washed with water to remove impurities, eluted with 1.5% ammonia water, collected the ammon...

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Abstract

The invention relates to a traditional Chinese medicine composition, and belongs to the field of Chinese herbal preparation. The traditional Chinese medicine composition is prepared by mixing 6-12 parts of cortex mori radicis, 3-6 parts of fenugreek seeds and 3-6 parts of coptis root, and carrying out water extraction, alcohol precipitation, ammonia water elution, concentration and drying, wherein the cortex mori radicis has remarkable functions of inhibiting alpha-glucosaccharase, delaying the absorption rate of glucose and fructose and reducing the postprandial blood glucose concentration after meal; the fenugreek seeds can obviously reduce the blood glucose level of a glycuresis mice, has the functions of adjusting the lipid metabolism, reducing triglyceride and cholesterol and rising high-density lipoprotein; and the natural bases extracted from the coptis root, particularly berberine, can activate adenine mononucleotide protein kinase (AMPK) in cells, enhance the consumption of glucose by cells, reduce the insulin resistance, etc. The extracts of the three traditional Chinese medicine can effectively reduce the blood glucose level, has a more remarkable effect in comparison with the traditional Chinese medicine with a single component, and can be used for preparing the traditional Chinese medicine composition for preventing and treating glycuresis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition with hypoglycemic effect containing Morus alba, Fenugreek and Coptis chinensis, a preparation method and application. Background technique [0002] Diabetes is a chronic, systemic, metabolic disease caused by long-term combined effects of genetic factors and environmental factors. A disease that disrupts normal physiological activities. [0003] If diabetes is not cured for a long time, acute and chronic complications will easily occur if the condition is not well controlled, which will affect all organs and tissues of the body and cause great harm. Acute complications of diabetes include hypoglycemia, diabetic ketoacidosis, hyperosmolar nonketotic diabetic coma, and diabetic lactic acidosis. The chronic complications of diabetes are mainly macrovascular and microvascular lesions, among wh...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61P3/10
Inventor 周阳峰
Owner HILL PHARMA
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