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Dual-mode contrast medium with fluorescence and magnetic resonance imaging and preparation method thereof

A magnetic resonance imaging, dual-mode technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, preparations for in vivo tests, pharmaceutical formulations, etc., can solve the problems of loss of fluorescence, poor stability, etc., to achieve strong relaxation ability, Mild reaction and less pollution

Inactive Publication Date: 2015-04-22
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, fluorescent dyes are prone to photobleaching and lose fluorescence, resulting in poor stability.

Method used

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  • Dual-mode contrast medium with fluorescence and magnetic resonance imaging and preparation method thereof
  • Dual-mode contrast medium with fluorescence and magnetic resonance imaging and preparation method thereof
  • Dual-mode contrast medium with fluorescence and magnetic resonance imaging and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Step 1): Prepare the precursor solution of zinc and manganese, that is, weigh 0.01 mmol of manganese stearate (0.006 g) and 0.8 mmol of zinc stearate (0.506 g), add them to 5 mL of octadecene, Sonicate for 30 minutes. The sulfur precursor solution was prepared by weighing 0.8 mmol of sulfur powder (0.026 g) and dissolving it in trioctylphos and oleylamine (volume ratio 1:1, 2 mL in total) to form a colloidal solution.

[0034] Step 2): Weigh 0.1 mmol of cuprous iodide (0.019 g) and 0.1 mmol of indium acetate (0.029 g) into 8 mL of octadecene, then add 1 mL of dodecanethiol, under vacuum at 80 °C and stirred for 1 hour. Infuse nitrogen, heat to 230°C, react for 25 minutes, stop the reaction, cool naturally to obtain uniform CuInS 2 colloidal solution.

[0035] Step 3): Add the precursor solution obtained in step 1) to the CuInS obtained in step 2) 2 The colloidal solution was repeatedly vacuumed three times, and finally, filled with nitrogen, heated to 210°C, and inj...

Embodiment 2

[0041] Step 1): Prepare the precursor solution of zinc and manganese, that is, weigh 0.1 mmol of manganese stearate (0.063 g) and 0.8 mmol of zinc stearate (0.506 g) into 5 mL of octadecene, Sonicate for 30 minutes. A sulfur precursor solution was prepared, that is, 0.8 mmol of sulfur powder (0.026 g) was dissolved in 2 mL of trioctylphosphine and oleylamine at a volume ratio of 1:1 to form a colloidal solution.

[0042] Step 2): Repeat steps 2) to 4) in Example 1 to obtain quantum dots with different manganese-doped core-shell structures, that is, the target product dual-mode contrast agent, which is stored in chloroform.

Embodiment 3

[0044] Step 1): Prepare the precursor solution of zinc and manganese, that is, weigh 0.2 mmol of manganese stearate (0.125 g) and 0.8 mmol of zinc stearate (0.506 g) into 5 mL of octadecene, Sonicate for 30 minutes. The sulfur precursor solution was prepared by dissolving 0.8 mmol of sulfur powder (0.026 g) in trioctylphosphine and oleylamine (volume ratio 1:1, 2 mL in total) to form a colloidal solution.

[0045] Step 2): Repeat steps 2) to 4) in Example 1 to obtain quantum dots with different manganese-doped core-shell structures, that is, the target product dual-mode contrast agent, which is stored in chloroform.

[0046] Step 3): Take 40 μL of thioglycolic acid and 0.5 mL of methanol, adjust the pH value to 12 with 40% sodium hydroxide solution, and add the obtained solution dropwise to the quantum dots obtained in step 2) (0.2 mmol) in chloroform solution, stirred for one hour to precipitate quantum dots, then added 5 mL of deionized water, stirred for 20 minutes, and st...

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Abstract

The invention discloses a dual-mode contrast medium with fluorescence and magnetic resonance imaging and a preparation method thereof. The dual-mode contrast medium is provided with a core-shell type structure comprising an inner core and an outer shell. The preparation method comprises the steps of: adding copper salts, indium salts and lauryl mercaptan to a reactor which is filled with a non-polar organic solvent, and reacting to obtain a uniform CuInS2 colloidal solution; adding a precursor solution of zinc and a precursor solution of manganese, and reacting to obtain a quantum-dot colloidal solution with the CuInS2 / Zn1-xMnxS core-shell structure; adding an extracting agent for extracting obtained quantum dots to obtain the CuInS2 / Zn1-xMnxS quantum dots with the core-shell structure, and dispersing in the non-polar organic solvent; and adding mercaptan acid, and carrying out ligand exchange, thereby obtaining the dual-mode contrast medium. The preparation method of the dual-mode contrast medium, provided by the invention, has the advantages of simplicity in operation, mild reaction and less pollution; and the dual-mode contrast medium does not contain toxic element cadium. The prepared dual-mode contrast medium has dual functions of fluorescence and magnetic resonance imaging and can be used for medical imaging diagnosis.

Description

technical field [0001] The present invention relates to the field of medical diagnostic imaging. More specifically, it relates to the design and synthesis of a dual-modal contrast agent that can be manipulated to obtain high-resolution magnetic resonance imaging (MRI) and optical imaging of biochemical activity in living organisms, as well as methods for its preparation. Background technique [0002] With the development of medical technology, imaging tools including magnetic resonance imaging, computed tomography (CT), positron emission tomography (PET), and fluorescence imaging have been widely used in medical diagnosis. Multimodal imaging systems that combine several of the above modalities have also been used in medical diagnostic research for cancer, heart disease, and gene therapy. MRI provides high-resolution three-dimensional anatomical or structural information, while fluorescence enables process visualization at the cellular level. Therefore, combining MRI techni...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06A61K49/12A61K49/00
Inventor 朱以华林八保杨晓玲邹文剑李昕沛
Owner EAST CHINA UNIV OF SCI & TECH
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