Dual-mode contrast medium with fluorescence and magnetic resonance imaging and preparation method thereof
A magnetic resonance imaging, dual-mode technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, preparations for in vivo tests, pharmaceutical formulations, etc., can solve the problems of loss of fluorescence, poor stability, etc., to achieve strong relaxation ability, Mild reaction and less pollution
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Embodiment 1
[0033] Step 1): Prepare the precursor solution of zinc and manganese, that is, weigh 0.01 mmol of manganese stearate (0.006 g) and 0.8 mmol of zinc stearate (0.506 g), add them to 5 mL of octadecene, Sonicate for 30 minutes. The sulfur precursor solution was prepared by weighing 0.8 mmol of sulfur powder (0.026 g) and dissolving it in trioctylphos and oleylamine (volume ratio 1:1, 2 mL in total) to form a colloidal solution.
[0034] Step 2): Weigh 0.1 mmol of cuprous iodide (0.019 g) and 0.1 mmol of indium acetate (0.029 g) into 8 mL of octadecene, then add 1 mL of dodecanethiol, under vacuum at 80 °C and stirred for 1 hour. Infuse nitrogen, heat to 230°C, react for 25 minutes, stop the reaction, cool naturally to obtain uniform CuInS 2 colloidal solution.
[0035] Step 3): Add the precursor solution obtained in step 1) to the CuInS obtained in step 2) 2 The colloidal solution was repeatedly vacuumed three times, and finally, filled with nitrogen, heated to 210°C, and inj...
Embodiment 2
[0041] Step 1): Prepare the precursor solution of zinc and manganese, that is, weigh 0.1 mmol of manganese stearate (0.063 g) and 0.8 mmol of zinc stearate (0.506 g) into 5 mL of octadecene, Sonicate for 30 minutes. A sulfur precursor solution was prepared, that is, 0.8 mmol of sulfur powder (0.026 g) was dissolved in 2 mL of trioctylphosphine and oleylamine at a volume ratio of 1:1 to form a colloidal solution.
[0042] Step 2): Repeat steps 2) to 4) in Example 1 to obtain quantum dots with different manganese-doped core-shell structures, that is, the target product dual-mode contrast agent, which is stored in chloroform.
Embodiment 3
[0044] Step 1): Prepare the precursor solution of zinc and manganese, that is, weigh 0.2 mmol of manganese stearate (0.125 g) and 0.8 mmol of zinc stearate (0.506 g) into 5 mL of octadecene, Sonicate for 30 minutes. The sulfur precursor solution was prepared by dissolving 0.8 mmol of sulfur powder (0.026 g) in trioctylphosphine and oleylamine (volume ratio 1:1, 2 mL in total) to form a colloidal solution.
[0045] Step 2): Repeat steps 2) to 4) in Example 1 to obtain quantum dots with different manganese-doped core-shell structures, that is, the target product dual-mode contrast agent, which is stored in chloroform.
[0046] Step 3): Take 40 μL of thioglycolic acid and 0.5 mL of methanol, adjust the pH value to 12 with 40% sodium hydroxide solution, and add the obtained solution dropwise to the quantum dots obtained in step 2) (0.2 mmol) in chloroform solution, stirred for one hour to precipitate quantum dots, then added 5 mL of deionized water, stirred for 20 minutes, and st...
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