Medical magnesium alloy surface mesoporous biological glass coating and preparation method

A technology of biological glass and bioactive glass, which is applied in medical science, prosthesis, surgery, etc., to achieve the effect of short production cycle, simple process and improved biological activity

Inactive Publication Date: 2014-01-08
TIANJIN UNIV
View PDF12 Cites 21 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN1785862A uses a hydrothermal method to prepare a calcium-silicon-based ordered mesoporous bioactive glass with a uniform pore size of about 5-10nm and a specific surface area of ​​200-600m 2 / g, which is more conducive to the formation of bone-like hydroxyapatite than traditional bioglass, but this patent does not use this bioglass as a coating to combine with the alloy matrix

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medical magnesium alloy surface mesoporous biological glass coating and preparation method
  • Medical magnesium alloy surface mesoporous biological glass coating and preparation method
  • Medical magnesium alloy surface mesoporous biological glass coating and preparation method

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] The preparation method of the mesoporous biological glass coating on the surface of medical magnesium alloy, the steps are as follows:

[0031] 1) Preparation of 45S5 bioactive glass sol system containing template

[0032] (1) According to SiO in 45S5 bioglass 2 / P 2 o 5 Weigh the ethyl orthosilicate and add it to the nitric acid solution to dissolve, stir and mix for 20-40 minutes, then add triethyl phosphate, continue stirring for 10-15 minutes, and control the temperature at 20-30°C throughout the process to obtain transparent Silicon-phosphorus-based precursor solution, wherein the molar ratio of Si / P is 46.14:5.2;

[0033] (2) According to CaO / Na in 45S5 bioglass 2 The mass ratio of O is taken by weighing soluble calcium salt and sodium salt, dissolved in deionized water to obtain calcium sodium inorganic salt solution, wherein the mol ratio of Ca / Na is 26.91:48.7;

[0034] (3) According to the critical micelle concentration value of the template agent, add th...

Embodiment 1

[0039] 1.45S5 bioactive glass sol system

[0040] With Ca(NO 3 ) 2 4H 2 O, NaNO 3 , tetraethyl orthosilicate and triethyl phosphate as raw materials, according to the Na in the 45S5 bioglass system 2 O-CaO-SiO 2 -P 2 o 5 The mass ratio is 24.5:24.5:45:6.0, and the medicines are weighed.

[0041] (1) Weigh 3.4ml tetraethyl orthosilicate (TEOS) dissolved in 2.4ml HNO with a concentration of 0.1mol / L 3 In the solution, stir and mix for 30 minutes, then add 0.29ml of triethyl phosphate (TEP), continue to stir for 15 minutes (the temperature is controlled between 20 and 30°C), and the molar ratio of Si / P is 46.14:5.2.

[0042] (2) Accurately weigh 1.38g NaNO 3 and 2.12g Ca(NO 3 ) 2 .4H 2 O, it was added to 40ml of deionized water, stirred to dissolve, the molar ratio of Ca / Na was 26.91:48.7.

[0043] (3) Weigh 3.46g of F127, slowly add it to 72ml of absolute ethanol, heat and stir (keep below 40°C) until the solution turns from cloudy to clear.

[0044] (4) According ...

Embodiment 2

[0049] 1.45S5 bioactive glass sol system

[0050] (1) Weigh 3.4ml tetraethyl orthosilicate (TEOS) dissolved in 2.4ml HNO with a concentration of 0.1mol / L 3 In the solution, stir and mix for 30 minutes, then add 0.29ml of triethyl phosphate (TEP), continue to stir for 15 minutes (keep the temperature between 20 and 30°C), and the molar ratio of Si / P is 46.14:5.2.

[0051] (2) Accurately weigh 1.38 grams of NaNO 3 and 2.12 g Ca(NO 3 ) 2 .4H 2 O, it was added to 40ml of deionized water, stirred to dissolve, the molar ratio of Ca / Na was 26.91:48.7, and the molar ratio of Ca / Na was 26.91:48.7.

[0052] (3) Weigh 0.44g of F127, slowly add it to 72ml of absolute ethanol, heat and stir (keep below 40°C) until the solution turns from turbid to clear, set aside.

[0053] (4) According to the template agent: 45S5 (Na 2 O-CaO-SiO 2 -P 2 o 5 ) with a mass ratio of 21:24.5:24.5:45:6.0 Add the ethanol solution (3) and calcium sodium salt solution (2) of the template agent F127 to th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
specific surface areaaaaaaaaaaa
thicknessaaaaaaaaaa
Login to view more

Abstract

The invention relates to a medical magnesium alloy surface mesoporous biological glass coating and a preparation method thereof. The composition of the coating is a 45S5 biological active glass (Na2O-CaO-SiO2-P2O5) system, wherein the mass ratio of the Na2O to CaO to SiO2 to P2O5 is 24.5:24.5:45:6.0; the coating has a mesoporous structure by adding a pore forming template agent. By using a sol-gel method and a dip-coating method, a sol coating containing the template agent is prepared on the surface of magnesium alloy, then gelation is performed, and thermal treatment is performed subsequently to discharge the template agent so as to finally obtain the mesoporous biological glass coating on the surface of the magnesium alloy. The process has a simple process and short production period; the obtained coating has good biological activity and degradability; the production of apatite and the cell adhesion are more facilitated due to the existence of mesopores; the structure of the mesoporous coating can be controlled by adjusting the conditions such as the content of the template agent, the thermal treatment temperature and the holding time, good interface bonding of the coating and a magnesium alloy substrate is realized, and the degradation performance of the magnesium alloy is adjusted and controlled.

Description

technical field [0001] The invention relates to a mesoporous biological glass coating with controllable degradation on the surface of a medical magnesium alloy and a preparation method thereof, belonging to the technical field of biological coating materials. Background technique [0002] As a biomedical implant material, magnesium alloy has good mechanical compatibility, biocompatibility and biodegradability, and can be used as a cardiovascular stent, bone fixation material, porous bone repair material, etc., and has a very broad application prospect. However, the rapid degradation rate of magnesium alloy in physiological environment restricts its application in the field of biomedicine. The criteria for identifying excellent degradable biomedical implant materials are: the effective service period in the human body is 3 to 6 months, and the allowable amount of hydrogen released in the body is less than 2.25ml / (cm 2 · d), the corrosion rate in the simulated body fluid is l...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/10A61L27/18A61L27/50A61L31/02A61L31/06A61L31/14
Inventor 蔡舒张睿悦黄凯牛书鑫赵欢
Owner TIANJIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap