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Method for preparing dimethyl carbonate by taking immobilized lipase as catalyst

A technology for immobilizing lipase and dimethyl carbonate, which is applied in the directions of immobilization on/in organic carriers, chemical industry, sustainable manufacturing/processing, etc., can solve problems such as catalyst deactivation, achieve high conversion rate, Broad application prospects and highly selective effects

Inactive Publication Date: 2014-01-22
SHENZHEN LEVEKING BIOLOGY ENG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the early 1980s, the EniChem company in Italy realized the commercialization of the synthesis of DMC by oxidative carbonylation of methanol using CuCl as a catalyst. This is the first industrialized non-phosgene synthesis of DMC, and it is also the most widely used. process, the defect of this process is that the deactivation of the catalyst is serious when the conversion rate is high, so its single-pass conversion rate is only 20%
However, the application of immobilized lipase to catalyze the preparation of dimethyl carbonate has not been reported.

Method used

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  • Method for preparing dimethyl carbonate by taking immobilized lipase as catalyst
  • Method for preparing dimethyl carbonate by taking immobilized lipase as catalyst
  • Method for preparing dimethyl carbonate by taking immobilized lipase as catalyst

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1) Immobilize lipase with substrate:

[0043] Add 400 grams of polyvinyl alcohol and 25 liters of deionized water in sequence in a 50-liter container to form a polyvinyl alcohol solution, heat until the polyvinyl alcohol solution boils, and keep stirring during the heating process to prevent the polyvinyl alcohol from sinking to the bottom of the container If it turns yellow due to excessive heat, a small amount of deionized water can be added during the boiling process to prevent the solution from overflowing. After boiling for about 50 minutes, the polyvinyl alcohol will basically dissolve; after cooling to room temperature, stir for 60 minutes until the polyvinyl alcohol solution is basically colorless and transparent; 100 grams The mixture of Penicillium extensa lipase and 300 grams of deionized water is added to the polyvinyl alcohol solution to obtain a mixed solution, and after stirring the mixed solution for 120 minutes, the mixed solution is evenly introduced in...

Embodiment 2

[0048] 1) Immobilize lipase with substrate:

[0049] Add 400 grams of hydroxypropyl methylcellulose and 25 liters of deionized water in sequence in a 50-liter container to form a hydroxypropyl methylcellulose solution, and heat until the hydroxypropyl methylcellulose solution boils. Stir continuously to prevent the hydroxypropyl methylcellulose from sinking into the bottom of the container and turn yellow due to excessive heat. During the boiling process, a small amount of deionized water can be added to prevent the solution from overflowing. After boiling for about 50 minutes, the hydroxypropyl methylcellulose is basically dissolved After being cooled to room temperature, stir for 60 minutes until the hydroxypropyl methylcellulose solution is basically colorless and transparent; the mixture of 100 grams of Penicillium extensa lipase and 300 grams of deionized water is added to the hydroxypropyl methylcellulose solution to obtain A mixed solution, after stirring the mixed solu...

Embodiment 3

[0054] 1) Immobilize lipase with substrate:

[0055] Add 400 grams of matrix (the mass ratio of polyvinyl alcohol in the matrix to sodium hydroxymethyl cellulose is 1:1) and 25 liters of deionized water successively in a 50-liter container to form a matrix solution, and heat until the matrix solution boils , Stir constantly during the heating process to prevent the substrate from sinking into the bottom of the container and turn yellow due to excessive heating. During the boiling process, a small amount of deionized water can be added to prevent the solution from overflowing. After boiling for about 50 minutes, the substrate basically dissolves; after cooling to room temperature, stir for 60 minutes Until the matrix solution is basically colorless and transparent; a mixture of 100 grams of Penicillium extensa lipase and 300 grams of deionized water is added to the matrix solution to obtain a mixed solution, and the mixed solution is evenly introduced after stirring the mixed so...

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Abstract

The invention discloses a method for preparing dimethyl carbonate by taking immobilized lipase as a catalyst. The method comprises the following steps of immobilizing lipase by taking one or two of polyvinyl alcohol, carboxymethyl cellulose sodium and hydroxypropyl methyl cellulose as a matrix for supporting lipase; then, sequentially adding reactants, namely methanol and ethylene carbonate or methanol and propylene carbonate into a reaction device; adding the immobilized lipase into the reactants; finally, stirring for a transesterification reaction to obtain a product, namely dimethyl carbonate. According to the method disclosed by the invention, by adopting the immobilized lipase as a catalyst to catalyze the transesterification reaction between methanol and ethylene carbonate or methanol and propylene carbonate to obtain dimethyl carbonate, the preparation method realizes high conversion rate, high selectivity and high universality; moreover, the technology is simple, the reaction conditions are mild, the cost is lowered, the method is environment-friendly, the immobilized lipase can be recycled, and the application prospect is broad.

Description

technical field [0001] The invention relates to the field of biochemical industry, in particular to a method for catalyzing the preparation of dimethyl carbonate by using immobilized lipase as a catalyst. Background technique [0002] Dimethyl carbonate (methyl-carbonate, DMC) is a colorless liquid at room temperature, with a boiling point of 90.1°C, a melting point of 4°C, and a density of 1.069g / cm 3 , Flash point (open cup) 21.7 ° C, water is partially miscible. However, it can be miscible with almost all organic solvents such as alcohols, ethers, and ketones. Dimethyl carbonate, as an organic synthesis raw material and chemical product, passed the registration of non-toxic chemicals in Europe in 1992, because its molecule contains various functional groups such as carbonyl, methyl and methoxy, and can be combined with phenol, Alcohols, amines, hydrazines, and ester compounds can completely replace highly toxic or carcinogenic substances such as phosgene, dimethyl sulfa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/00C12N11/12C12N11/08
CPCY02P20/50
Inventor 张海波王剑英刘骏郭宏涛兰瑛周晓海
Owner SHENZHEN LEVEKING BIOLOGY ENG
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