Toltrazuril alkali metal salt as well as preparation method and application thereof
A technology of toltrazuril and alkali metal salts, which is applied in the fields of active ingredients of heterocyclic compounds, anti-infective drugs, organic chemistry, etc., which can solve the problem of weak conventional drug prevention, disinfection and vaccine epidemic prevention, and insufficient intake of toltrazuril , Inability to give full play to the efficacy of the drug, etc., to achieve the effect of less drug resistance, significant curative effect, and drug resistance
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Embodiment 1
[0021] 1) Weigh 50g of toltrazuril into a 2000mL three-necked flask, then add 650mL of ethanol, stir at room temperature to obtain a white turbid emulsion;
[0022] 2) Weigh 9.8g of potassium hydroxide and place it in a beaker, then add ethanol, stir until the potassium hydroxide is completely dissolved, and prepare a potassium hydroxide ethanol solution with a concentration of 7% by mass;
[0023] 3) Add the potassium hydroxide ethanol solution in step 2) dropwise to the emulsion in step 1) at a rate of 1mL / min under stirring conditions. After the dropwise addition is completed, continue to stir for 4 hours, and the solution gradually becomes clear , TLC shows that the reaction of the raw materials has been completed, and the reacted solution is spin-dried to obtain a viscous white solid, then a sufficient amount of petroleum ether is added for dehydration, spin-dried to remove water, and then dried to obtain 55.05g of white thoroxine Quzhuli potassium salt crude product, pro...
Embodiment 2
[0034] 1) Weigh 50g of toltrazuril into a 2000mL three-neck flask, then add 750mL of ethanol, stir at room temperature to obtain a white turbid emulsion;
[0035]2) Weigh 14.56g of potassium hydroxide and place it in a beaker, then add ethanol, stir until the potassium hydroxide is completely dissolved, and prepare a potassium hydroxide ethanol solution with a mass percentage concentration of 10%. The ethanol can also use methanol, propylene glycol, petroleum ether or ethyl acetate instead;
[0036] 3) Add the potassium hydroxide ethanol solution in step 2) dropwise to the emulsion in step 1) at a rate of 5mL / min. After the dropwise addition, continue to stir for 5 hours, the solution gradually becomes clear, and TLC shows that the raw material After the reaction has been completed, the reacted solution is spin-dried to obtain a viscous white solid, then a sufficient amount of ethanol is added for dehydration, spin-dried to remove water, and 51.11g of white crude product of to...
Embodiment 3
[0047] 1) Weigh 50g toltrazuril into a 2000mL three-neck flask, then add 800mL isopropanol, and stir at room temperature until a white turbid emulsion is obtained;
[0048] 2) Weigh 11.42g of potassium hydroxide and place it in a beaker, then add isopropanol, stir until the potassium hydroxide is completely dissolved, and prepare a potassium hydroxide isopropanol solution with a concentration of 8% by mass;
[0049] 3) Add the potassium hydroxide isopropanol solution in step 2) dropwise to the emulsion in step 1) at a rate of 3mL / min. After the dropwise addition is completed, continue to stir for 2 hours, and the solution gradually becomes clear. TLC After showing that the raw materials have been reacted, spin the reacted solution to obtain a viscous white solid, then add a sufficient amount of ethanol, spin to remove water, and obtain 45.93g of white crude product of tortrazuril potassium salt. rate of 74.8%;
[0050] 4) Mix isopropanol and ethyl acetate at a volume ratio of...
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