Extraction method of lincomycin
A technology of lincomycin and extraction method, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of low purity, large solvent consumption, low yield of lincomycin, etc. The effect of low impurity content, improved extraction efficiency and high product yield
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Embodiment 1
[0034] Take 150 kg of lincomycin fermentation broth, add oxalic acid to adjust the pH to 3, and then filter through the first ceramic ultrafiltration membrane, the ceramic membrane has a pore size of 0.05 μm, a pressure of 0.2 MPa, and a membrane surface flow rate of 2 m / s. Take the filtered acidification solution and use concentrated alkali to adjust the pH to 11, then pass the alkalization solution through the second ceramic ultrafiltration membrane again, the ceramic membrane has a pore size of 0.05 μm, a pressure of 0.1 MPa, and a membrane surface flow rate of 2 m / s. Add 2-octanol to the alkalization solution, the dosage is 1 / 10 of the volume of the second ceramic membrane clear solution, stir at room temperature for 5 minutes and let it stand for stratification. The stratification process is faster, the interface is clear, and there is no emulsification phenomenon. Secondary octanol was added to the waste liquid after the first extraction, the dosage was 1 / 10 of the volume...
Embodiment 2
[0037] Regarding the selection of the extractant, in the present embodiment, some common extractants are used in the extraction step. The difference from Example 1 is that the extractants shown in Table 1 are used respectively. The extraction method is the same, and it is obtained The final product testing results are shown in Table 1.
[0038] Table 1 Effect of different extractants on product results
[0039] Extracting agent 2-octyl alcohol Butanol Isobutanol Isoamyl alcohol Second-pentanol Content % 97.9 95.1 96.8 95.7 96.1 Impurity B % 0.43 0.75 0.87 0.75 0.71 Yield % 95.2 92.5 90.2 91.3 88.4
[0040] As can be seen from the table, with secondary octanol as the extractant, the content, yield and other indicators of the product obtained are better than other extractants.
[0041]
Embodiment 3
[0043] Take 150kg of lincomycin fermentation broth, add oxalic acid to adjust the pH to 4, and then filter through the first ceramic ultrafiltration membrane. The ceramic membrane has a pore size of 0.02 μm, a pressure of 0.1 MPa, and a membrane surface flow velocity of 5 m / s. Take the filtered acidification solution and use concentrated alkali to adjust the pH to 11, then pass the alkalization solution through the second ceramic ultrafiltration membrane again. Add 2-octanol to the alkaline solution, the dosage is 1 / 8 of the volume of the second ceramic membrane clear solution, stir at room temperature for 5 minutes and let it stand for stratification. The stratification process is fast, the interface is clear, and no emulsification occurs. Add secondary octanol to the waste liquid after the first extraction, the dosage is 1 / 8 of the volume of the second ceramic membrane liquid, stir at room temperature for 5 minutes and let stand to separate. Combine the organic phases and ad...
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