The present application relates to the technical field of
asiatic acid, and particularly relates to an
asiatic acid derivative and a preparation method. The
asiatic acid derivative provided by the present application has R which is an
alkyl group formed by removing a hydroxyl group from a saturated or unsaturated monohydric
alcohol, and the saturated or unsaturated monohydric
alcohol includes one of
ethanol,
octanol, hexadecanol,
stearyl alcohol, 2-hexyl-1-decanol, decyltetradecin,
oleyl alcohol, cis,cis-9,12-octadecadienol and
bisabolol. The asiatic
acid derivative of the present application has higher water
solubility and oil
solubility, especially oil
solubility, so that the asiatic
acid derivative has obviously enhanced liposolubility, is easily soluble in natural oil,
alkane and other ester solvents, and has a significant
inhibitory effect on EDNRA and TRPV1 and obviously enhanced bioactivity. The asiatic
acid derivative of the present application has
high availability, and the asiatic acid derivative has no
safety risk.