The invention discloses an oil gas purification device used in a deep-sea confined space, which comprises a condensation nucleation generating device, an oil and gas suction device, an oil gas condensing device, a centrifugal separation device, an oil collection tank and a filtering and purification device. The condensation nucleation generating device includes a first Water pipe, first heater, atomizer, air compressor and dryer; oil and gas suction device includes oil and gas inlet pipe, second heater and fan; oil and gas condensing device includes second water inlet pipe, shell and tube condenser and outlet water pipe; the oil collection tank is arranged under the housing; the centrifugal separation device includes a driving motor and a centrifugal impeller; the inlet of the filtering and purifying device is connected to the outlet on the side wall of the housing, and the outlets of the filtering and purifying device are respectively connected to Air pipe and air compressor inlet. The invention can improve the oil and gas purification efficiency, better improve the air quality in the deep-sea confined space, save energy, reduce noise, increase the service life of the system, and reduce the use cost of the system.