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Core-shell nanofiber wrapping lipidosome

A technology of nanofibers and liposomes, which is applied to core-shell nanofibers containing liposomes in the core layer. In the field of preparation, it can solve the problems of unfavorable controlled release of contents, leakage of contents, rupture of liposomes, etc., and achieve good results. The effect of biocompatibility, low price, and simple preparation method

Inactive Publication Date: 2014-04-30
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the mixed solution of liposomes and polymers is used for direct uniaxial electrospinning, the liposomes are prone to rupture due to the high shear force exerted by the polymer solution, and the contents of the liposomes are easily broken. Leakage, which is detrimental to controlled release of contents

Method used

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  • Core-shell nanofiber wrapping lipidosome
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  • Core-shell nanofiber wrapping lipidosome

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Example 1: Preparation of sodium hyaluronate / cellulose acetate core-shell nanofibers containing naproxen in liposomes and its in vitro drug release determination

[0043] (1) Preparation of drug-loaded liposomes by lipid membrane hydration method: Lecithin (purchased from Aladdin, extracted from soybeans, purity> 98%) 160mg, cholesterol (purchased from Alfa Aesar, article number A11470, purity 95%) 20mg and naproxen (purchased from Alfa Aesar) 90mg were added to a 250mL round bottom flask, and then 5mL chloroform / methanol mixed solvent (v / v=2 / 1). After being fully dissolved, use a rotary evaporator to evaporate the solvent to a lipid film in a constant temperature water bath of about 30°C and a rotation speed of 60 rpm;

[0044] (2) Add 5 mL of ultrapure water and 0.5 g of glass beads to the above lipid membrane. The rotary evaporator was used again to rotate for 30 minutes in a constant temperature water bath at about 30° C. and a rotation speed of 60 rpm in a nitrogen env...

Embodiment 2

[0047] Example 2: Preparation of sodium hyaluronate / polyvinylpyrrolidone core-shell nanofibers containing rhodamine B in liposomes

[0048] (1) Preparation of fluorescent dye-loaded liposomes by lipid membrane hydration method: 80mg of lecithin (purchased from Alfa Aesar, extracted from soybeans, item number 36486), cholesterol (purchased from Alfa Aesar, item number A11470, purity 95%) Add 10mg to a 250mL round-bottom flask, and then add 5mL chloroform / methanol mixed solvent (v / v=2 / 1). After it is fully dissolved, use a rotary evaporator to evaporate the solvent in a constant temperature water bath at 30℃ and a rotation speed of 60rpm Get lipid film;

[0049] (2) Add 5 mL of a preformed Rhodamine B (purchased from Sigma Aldrich) aqueous solution with a concentration of 3 mg / mL to the above lipid film, and again use a rotary evaporator in a nitrogen environment at a constant temperature water bath of about 30°C and a rotation speed of 60 rpm Rotate for 30 min to obtain a suspensio...

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Abstract

The invention relates to a core-shell nanofiber wrapping lipidosome and a preparation method and application thereof. The core-shell nanofiber is characterized in that the shell layer of the nanofiber is made from biocompatible polymer, the core layer of the nanofiber is made from natural polyelectrolyte, the lipidosome is wrapped in the core layer of the fiber and is loaded with active substances, the diameter of the core-shell nanofiber is 100-800 nm, and the core-shell nanofiber can control the active substance in the lipidosome to be slowly released to be balanced within 8-14 days. The core-shell nanofiber material prepared by the method has good biocompability, can control the release of growth factors, antibacterial peptide and various active drugs, is stable in performance and easy to store, and has wide application prospect.

Description

Technical field [0001] The present invention belongs to the field of preparation of core-shell nanofibers. Specifically, the present invention relates to a core-shell nanofiber with a core layer containing liposomes, a preparation method and use thereof. Background technique [0002] Electrospinning technology refers to the process of polymer solution forming fibers under the action of high-voltage electrostatic field. The technology is simple and convenient. The diameter of the prepared fiber is about 0.05-5μm, and the specific surface area is about 1-100m. 2 / g, the porosity of the membrane is as high as about 90% and the pore size is less than about 100 nm. These characteristics make the electrospun fiber membrane can be used in fabrics, filter membranes, composite reinforcements, wound dressings, tissue engineering scaffolds, sensors, optoelectronic devices, and catalysis. [0003] Electrospinning fiber membrane has the properties of air permeability blocking bacteria, non-adh...

Claims

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Application Information

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IPC IPC(8): D01F8/00D01F1/10
Inventor 刘瑞刚李状康宏亮黄勇
Owner INST OF CHEM CHINESE ACAD OF SCI
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