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Anti-cervical erosion suppository and preparation method thereof

A technology for eliminating emollient suppositories and fine powders is applied in the directions of suppository delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. Stable physical and chemical properties, complete and smooth appearance

Active Publication Date: 2014-05-21
TONGHUA MAOXIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The drug has a high melting point and is not easy to dissolve at body temperature, which affects the absorption time of the drug; it has strong hygroscopicity and is easy to absorb moisture and get deformed by moisture, especially for the rainy weather in the south; Broken, very inconvenient to use

Method used

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  • Anti-cervical erosion suppository and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0019] A preparation method for Xiaomi suppository: 1. Catechin and dried alum are crushed into fine powder, and borneol is ground into fine powder; Cortex Phellodendri, Sophora flavescens, and Comfrey are decocted with water for three times, the first time for 2 hours, and the second and third times respectively. For 1 hour, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.10 (80°C), add ethanol to make the alcohol content 75%, let it stand for 24 hours, filter, recover ethanol, and concentrate to a relative density It is a thick paste of 1.36 (80°C), dried, crushed into fine powder, and mixed with the above fine powder and ginseng stem and leaf saponin powder; （38） Ester and polyethylene glycol 1500, mix and heat to melt, keep the temperature at 40°C ± 2°C, add the above fine powder, stir well, pour into suppository mold, cool down, and make 1000 suppositories.

Embodiment 2

[0021] A preparation method for Xiaomi suppository: 1. Catechin and dried alum are crushed into fine powder, and borneol is ground into fine powder; Cortex Phellodendri, Sophora flavescens, and Comfrey are decocted with water for three times, the first time for 2 hours, and the second and third times respectively. For 1 hour, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.10 (80°C), add ethanol to make the alcohol content 75%, let it stand for 24 hours, filter, recover ethanol, and concentrate to a relative density It is a thick paste of 1.36 (80°C), dried, crushed into fine powder, and mixed with the above fine powder and ginseng stem and leaf saponin powder; （39） Ester and polyethylene glycol 1500, mix and heat to melt, keep the temperature at 40°C ± 2°C, add the above fine powder, stir well, pour into suppository mold, cool down, and make 1000 suppositories.

Embodiment 3

[0023] A preparation method for Xiaomi suppository: 1. Catechin and dried alum are crushed into fine powder, and borneol is ground into fine powder; Cortex Phellodendri, Sophora flavescens, and Comfrey are decocted with water for three times, the first time for 2 hours, and the second and third times respectively. For 1 hour, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.10 (80°C), add ethanol to make the alcohol content 75%, let it stand for 24 hours, filter, recover ethanol, and concentrate to a relative density It is a thick paste of 1.36 (80°C), dried, crushed into fine powder, and mixed with the above fine powder and ginseng stem and leaf saponin powder; （40） Ester and polyethylene glycol 1500, mix and heat to melt, keep the temperature at 40°C ± 2°C, add the above fine powder, stir well, pour into suppository mold, cool down, and make 1000 suppositories.

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Abstract

The invention relates to the field of traditional Chinese medicines and provides an anti-cervical erosion suppository and a preparation method thereof. The anti-cervical erosion suppository is prepared from ginsenoside, lithospermum, golden cypress, sophora flavescens, dried alums and acacia catechu. The preparation method comprises the following steps: grinding the acacia catech and the dried alums into fine powder; grinding borneol; adding water into the golden cypress, the sophora flavescens and the lithospermum and decocting for three times; mixing decoction solutions and filtering; adding ethanol and standing for 24 hours; recycling the ethanol and concentrating into thick paste; drying and crushing into fine powder; uniformly mixing with the fine powder; additionally adding base materials including polyoxyl stearate and polyethylene glycol 1500; mixing, heating and smelting; and adding the fine powder and uniformly agitating to prepare a suppository. The anti-cervical erosion suppository has good water solubility, no stimulation, no toxin, no anaphylaxis, and is stable in physicochemical property; the anti-cervical erosion suppository is not easily deformed due to moisture absorption and is not easy to mildew; at a room temperature, the anti-cervical erosion suppository has suitable rigidity and has no deformation and crushing in a packaging, transporting and storing process.

Description

[0001] technical field [0002] The invention relates to the field of traditional Chinese medicine, in particular to a Xiaomi suppository and a preparation method thereof. Background technique [0003] Trichomonal vaginitis is a vaginitis caused by Trichomonas vaginalis. The main symptoms of patients are thin foamy vaginal discharge and genital itching, which may be accompanied by burning sensation, pain and dyspareunia. Mycotic vaginitis is a common male and female genital disease. The disease is easily spread among women. Its main symptoms are excessive leucorrhea, burning and itching of the vulva and vagina. According to the survey, vaginitis is the most common inflammation in women. 75% of women have suffered from mycotic vaginitis at least once in their lifetime, and 20% to 30% of them may cause infertility. [0004] Guoyao Zhunzi No. Z22024888 "Xiaomi suppository" is effective in treating vaginitis, especially for trichomonal vaginitis and fungal vaginitis. Functions ...

Claims

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Application Information

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IPC IPC(8): A61K36/75A61K9/02A61P15/02A61P33/02A61K33/06A61K31/045
Inventor 王茂祥贺天鹏于静涛李明国
Owner TONGHUA MAOXIANG PHARMA
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