Series quadrupole-rod gas-chromatographic mass spectrometry detection method for 35 toxic medicaments in urine

A gas chromatography-mass spectrometry, tandem quadrupole technology, which is used in measuring devices, instruments, scientific instruments, etc., can solve the problem of not being able to achieve one-time detection, and achieve the effects of eliminating interference, wide application and simple operation.

Inactive Publication Date: 2014-05-21
FUJIAN INT TRAVEL HEALTH CARE CENT
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  • Abstract
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Problems solved by technology

[0010] In the comparison document with Chinese patent number 201110075177.4, the urine is pretreated by the classic liquid-liquid extraction method, ethyl acetate is used as the extraction solvent, a

Method used

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  • Series quadrupole-rod gas-chromatographic mass spectrometry detection method for 35 toxic medicaments in urine
  • Series quadrupole-rod gas-chromatographic mass spectrometry detection method for 35 toxic medicaments in urine
  • Series quadrupole-rod gas-chromatographic mass spectrometry detection method for 35 toxic medicaments in urine

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Embodiment Construction

[0044] The present invention is described in detail below in conjunction with example

[0045] 1 instrument

[0046] Instrument: Agilent7890GC / 7000QQQB.

[0047] 2 reagents

[0048] 2.1 Drugs: Among the standard products of 35 kinds of poisons (drugs) within the determination range, diazepam and MDMA are 500μg / ml methanol solution, tetramine is 250μg / ml ethyl acetate solution, and others are 1mg / mL methanol solution. Purchased from the Institute of Forensic Science and Technology of the Ministry of Justice.

[0049] 2.2 Reagents: Cyclohexane, ethyl acetate, chloroform, ether, phosphoric acid, sodium dihydrogen phosphate, sodium hydroxide, sodium carbonate, sodium bicarbonate, hydrochloric acid, etc. are analytically pure; methanol is chromatographically pure.

[0050] 2.3 Preparation of standard solution: the concentrations of dichlorvos, dimethoate, methyl parathion, malathion, parathion and tetramine in the methanol solution of the 35 poisons (drugs) mixed standard were ...

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Abstract

The invention discloses a series quadrupole-rod gas-chromatographic mass spectrometry detection method for 35 toxic medicaments in urine. The series quadrupole-rod gas-chromatographic mass spectrometry detection method comprises the steps of constructing a multiple-reaction detection method on a series quadrupole-rod gas chromatograph-mass spectrometer through standard substances of 35 toxicants (medicines), and determining 2-3 pairs of feature parent ions and daughter ions and the retention time of each toxicants (medicines); extracting a urine sample to be detected through diethyl ether, performing ultrasonic and centrifugal treatment, blow-drying and dissolving, and then qualitatively and quantitatively analyzing the toxicants (medicines) through a tandem mass spectrum MRM. By the adoption of a series quadrupole-rod gas-chromatographic-mass spectrometry/mass spectrometry method (GC-MS/MS), the method disclosed by the invention can quickly screen 35 conventional toxicants (medicines) in the urine of a human body; a detection result is accurate, sensitive and quick; the recycling rate of toxicants (medicines) is 80.82-118.56 percent; the detection limit is up to 0.0014-1.8 micrograms per microliter.

Description

technical field [0001] The invention belongs to a tandem quadrupole gas chromatography mass spectrometry detection method for 35 kinds of poisons in urine. Background technique [0002] Drug abuse and drug trafficking have become a global social hazard. Once a person is addicted to drugs, he will often indulge in the deformed "pleasure" imagined by drugs, and have no intention of working and studying. Drug use can also cause a series of family and social problems. In view of the serious harm of drug use to families, especially to society, some foreign countries, in addition to taking corresponding management measures for their own drug users, also require applicants to provide proof of non-drug use, such as Russia, Belgium, Hong Kong and so on. As the process of global economic integration accelerates, it is inevitable that other countries will introduce similar regulations for immigrants one after another. In order to actively respond to the requirements of some foreign ...

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Application Information

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IPC IPC(8): G01N30/88
Inventor 曹洁高博黄恩炯张建明闫育培郑幼灵
Owner FUJIAN INT TRAVEL HEALTH CARE CENT
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