A kind of vinca alkaloid drug carrier and preparation method thereof

A vinca alkaloid and carrier technology, which can be used in drug combinations, pharmaceutical formulations, antitumor drugs, etc., can solve problems such as unsatisfactory drug loading and unstable drug encapsulation efficiency.
CN104072664BInactive Publication Date: 2016-03-02SOUTHERN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTHERN MEDICAL UNIVERSITY
Publication Date
2016-03-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a catharanthus roseus alkaloidal drug carrier which is a copolymer of which the constitutional repeating unit is shown in the formula (1) in the description. The molar ratio of a functional monomer, namely N-acryloyl-L-tryptophan, to a crosslinking monomer, namely ethylene glycol dimethyl acrylate, is 67 / 33 in the copolymer, and the copolymer is prepared through water bath polymerization of the functional monomer and the crosslinking monomer. The drug carrier has the advantages that the biocompatibility is good, the drug loading capacity is large, and the drug is difficult to leak and release abruptly.
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Description

technical field

[0001] The present invention relates to a medical preparation, which is characterized by the organic polymer compound used. Background technique

[0002] Vinblastine, vincristine, and vinorelbine are currently clinically used antineoplastic drugs. Due to the existence of therapeutic barriers, that is, the non-selective killing of normal cells and tumor cells, it often brings unacceptable side effects to patients, such as neurotoxicity, bone marrow suppression, leukopenia, anemia, etc., which limits its clinical application. use. In order to improve the clinical efficacy of vinca alkaloids and reduce their adverse reactions, new drug delivery systems such as liposomes, micelles, microemulsions, and microspheres have emerged in recent years. Although the emergence of new carriers has improved the clinical application of chemotherapy drugs to a certain extent, there are still problems such as easy leakage of drugs, short action time and biological safety of ca...

Claims

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