Preparation method for 2-hydroxy-4-methylthio-calcuim butyrate

Abstract

The invention discloses a preparation method for 2-hydroxy-4-methylthio-calcuim butyrate. The method is characterized by comprising the following step of reacting reaction raw materials comprising a 2-hydroxy-4-methylthio-butyric acid solution and one or more of calcium hydroxide, calcium oxide and calcium carbonate with ammonium bisulfate introduced as an organic reaction catalyst to obtain the 2-hydroxy-4-methylthio-calcuim butyrate. The method has the advantages of being mild in reaction, free of specific stirring tools, high in universality, less in equipment investment, low in production cost, convenient to use, mild and controllable in the whole reaction process, low in probability of product decomposition or coking rate, complete in reaction, time-saving, high in product yield, purity and yield, energy-saving and more environment-friendly.

Description

technical field [0001] The invention relates to the technical field of food or feed additive production methods, in particular to a preparation method of 2-hydroxy-4-methylthio-butyrate calcium. Background technique [0002] 2-Amino-4-methylthio-butyric acid, commonly known as calcium hydroxymethionine (CAS No.4857-44-7); is often used in animal feed as an amino acid feed additive, and it is an animal growth promoter , used for protein synthesis, can improve animal growth rate and poultry egg production rate. 5-hydantoin is hydrolyzed, and then carbon dioxide is introduced into the hydrolyzate for neutralization, so that methionine is crystallized and precipitated. However, this process has the disadvantages of huge production investment, expensive equipment, complex technology, long process line and high production cost, so it is not an economical method. [0003] For this reason, scientific and technical personnel have developed methionine analogues such as 2-hydroxy-4-m...

AI Technical Summary

Problems solved by technology

But, the preparation method of above-mentioned 2-hydroxyl-4-methylthio-butyric acid calcium has the following defects: when solid state calcium oxide or calcium hydroxide and liquid state 2-hydroxyl-4-methylthio-butyric acid start It is difficult to mix and the reaction is also difficult, but once the two react, the reaction will be very violent and the reaction speed will be very fast. On the one hand, the pressure in the reaction vessel will increase rapidly and a large amount of heat will be generated, resulting in Reaction rate, pressure and temperature are difficult to control, and after temperature is greater than 130 degrees, product 2-hydroxyl-4-methylthio-calcium butyrate can decompose or coke, on the other hand, a part of material (such as calcium oxide or hydroxide Calcium or intermediate products, etc.) are easily wrapped into large groups or large pieces, unable to fully participate in the reaction, resulting in a relatively insufficient amount of reaction raw materials, insufficient reaction, more intermediate products, and low product purity, thereby affecting product yield and quality

[0004] The applicant applied for the application number 2012100885716 on March 30, 2012, and the title is "A Preparation Method for Calcium 2-Hydroxy-4-Methylthio-Butyrate". In this patent application, the applicant, in order to overcome the oxidation of solid state Calcium or calcium hydroxide reacts violently with 2-hydroxy-4-methylthio-butyric acid in liquid state, and the reaction speed is very fast to generate a large a...