Multi-channel nerve repair catheter and mold with tissue inductive function

Abstract

A multi-channel nerve repair catheter and mold with tissue-inducing function. Chitosan-coated salidroside microspheres and composite salidroside sustained-release microspheres were prepared. The cumulative drug release amount was calculated by different The composite salidroside sustained-release microspheres with high content are mixed with type I collagen to obtain salidroside sustained-release microspheres / type I collagen; the multi-aperture columnar nerve conduit core layer is prepared by using a mold, and the high-voltage electrospinning technology The shell layer of the nanofiber nerve conduit is prepared, and the core layer and the shell layer are nested to obtain a multi-channel nerve repair conduit with tissue-inducing function. The shell of the catheter has a good function of exchanging with interstitial fluid and has the function of guiding nerve growth; the core layer can guide the directional growth of nerve fibers, promote the directional differentiation of stem cells into Schwannsch cells, accelerate the growth of nerve fibers and restore function; effectively repair peripheral Nerve defect, with good degradability and biocompatibility, meets the requirements of tissue engineering scaffold materials.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a nerve repair catheter, in particular to a multi-channel nerve repair catheter with tissue inductive function; the invention also relates to a mold used in the preparation process of the multi-channel nerve repair catheter. Background technique [0002] Peripheral nerve injury is one of the most common clinical injuries. With the development of modern construction industry, transportation industry and the frequent occurrence of major natural disasters and local wars, the incidence of peripheral nerve injury is increasing year by year. Peripheral nerve injury often causes degeneration and dysfunction in the innervated area, which affects the physical and mental health and quality of life of patients for a long time, and has become one of the challenges facing the world's medicine. [0003] The use of tissue engineering methods to construct different nerve conduits through natural...

AI Technical Summary

Problems solved by technology

Whether the traditional first-generation tissue-engineered nerve conduits are natural materials or artificial materials, the main function is to guide nerve fiber regeneration. The main problems are: 1) Different materials have different biocompatibility; 2) The degradation performance of materials is different, which affects the regeneration of nerves; 3) it is easy to form scar structures, which seriously affects the biological functions of regenerated nerves; 4) the synthetic polymer materials lack cell recognition sites

However, the biggest problem facing this type of material is that the material lacks tissue induction (tissue induction refers to a new type of biomaterial that can directly induce the regeneration of living tissue. , and can induce cells to form tissue) functions, cannot fully simulate the tissue microenvironment suitable for cells and hosts, and is still far from ideal materials in terms of nerve regeneration and repair

[0005] The main problem faced by tissue-inducing nerve repair materials is that although materials constructed by compounding nerve-related growth factors, gene carriers or slow-release methods have tissue-inducing functions, the compounded active factors have unstable performance, easy inactivation and Shortcomings such as sudden release cannot achieve the goal of active repair function in the true sense

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