Amphiphilic Eu (III) complex, preparation method thereof and application thereof in sensing identification of citric acid/isocitric acid

Abstract

The invention discloses an amphiphilic Eu (III) complex, a preparation method thereof and application thereof in sensing identification of citric acid / isocitric acid. The structural formula of the complex is shown in the specification; the complex is prepared by complexing a compound with lanthanide-series Eu (III), wherein the compound contain a double-alkyl-chain flexible tail group and a double pyridine carboxylic acid head group and serves as a ligand; the preparation method is simple and reaction conditions are mild. The amphiphilic Eu (III) complex has the characteristics that the fluorescent life is long, Stokes shift is large, and the coordination is unsaturated; the amphiphilic Eu (III) complex can be self-assembled in a water phase to form a vesicular supermolecule sensing interface with stable structure and uniform size, the vesicular supermolecule sensing interface is taken as a sensing platform, and by virtue of a synergetic complexation action between the Eu (III) complex assembled on the surfaces of vesicae and negative ions as well as the difference in capability of substituting water molecules bonded to Eu (III) ions by using carboxylic acid, the fluorescent sensitization degrees of the Eu (III) ions on the surface of the vesicae are differed, so that the high-sensitive and high-selectivity differentiation and identification for citric acid and isocitric acid and detection are achieved.

Description

technical field [0001] The invention belongs to the technical field of supramolecular sensing materials, and specifically relates to an amphiphilic Eu(III) complex and a preparation method thereof, and a preparation method and application of a vesicle-type fluorescent supramolecular sensor. Background technique [0002] Citric acid exists in all living cells, participates in the metabolism and energy storage process of most living organisms, and is an important intermediate in the tricarboxylic acid cycle. It not only serves as a precursor for the synthesis of new biomolecules, but also is an important component of fatty acid synthesis, photorespiration, glyoxylate cycle, and nitrogen metabolism. Isocitrate is an isomer of citric acid. Under the catalysis of aconitase, citric acid can be converted into isocitrate, and the physiological functions of isocitrate and citric acid are quite different. Therefore, the sensory recognition Citric acid and isocitric acid are of great ...

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Problems solved by technology

[0003] Traditional methods for identifying and detecting citric acid include chromatographic analysis, electrolytic analysis, enzymatic method, and single-molecule fluorescence sensing method, while the detection methods for isocitric acid are mostly high-performance liquid chromatography, although the above methods can be used to detect lemon acid or isocitric acid, but most methods have disadvantages such as high experimental cost, large measurement error, low sensitivity and narrow application range

In addition, sensors that can be used to distinguish citric acid and isocitric acid have not been reported yet, and it is more challenging to achieve efficient recognition of citric acid and isocitric acid under physiological conditions, which requires not only sensing units and different There are differences in the interaction between the anions of different species, and this difference can be transformed into easily detectable physicochemical signals

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