Phosphorylcholine-containing high-strength polyurethane hydrogel and preparation method thereof

Abstract

The invention relates to a phosphorylcholine-containing high-strength polyurethane hydrogel and a preparation method thereof, and the hydrogel is prepared from a double-bond-terminated polyurethane segmented copolymer, 2-methacryloyloxyethyl phosphorylcholine and an alkene copolymerization monomer through free radical copolymerization. The hydrogel is prepared by dissolving the double-bond-terminated polyurethane segmented copolymer, 2-methacryloyloxyethyl phosphorylcholine, the alkene copolymerization monomer and an initiator in a solvent, and performing ultraviolet-initiated free radical polymerization reaction at room temperature. The preparation method is simple, the raw material source is wide, and the prepared hydrogel is good in biocompatibility, also possesses extremely strong compression resistance and tensile resistance, can be used as a tissue engineering restoration skeleton material and the like, and possesses obvious application prospect in the field of biomedical materials.

Description

technical field [0001] The invention belongs to the field of polymer hydrogels, in particular to a phosphorylcholine-containing high-strength polyurethane hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a cross-linked network composed of hydrophilic polymers that can swell in water and retain a large amount of water without being dissolved. It is widely used in biomedicine, food, chemical industry, agriculture and other fields. Due to the disordered distribution of crosslinking points in the traditional polymer hydrogel, it is easy to cause stress concentration, which leads to its low mechanical strength (generally it can only resist about 20-100kPa of compressive strength and is easily crushed, while its tensile strength is only 8~14kPa, and the elongation at break is 20~50%), which has seriously affected its application in tissue engineering. Some soft tissues in the human body (such as ligaments, tendons, articular cartilage, etc.) ar...

AI Technical Summary

Problems solved by technology

Although the mechanical properties of the prepared hydrogel (tensile strength 30-50kPa, elongation at break 1100-2400%) have been greatly improved compared with traditional acrylamide hydrogels, they still cannot fully meet the needs of articular cartilage repair materials. needs

In the above-mentioned polyurethane hydrogel, the hydrophilic groups or segments on the polyurethane macromolecular chain will preferentially form hydrogen bonds with water molecules and swell in water, thereby hindering the hard segment and hard segment of the polyurethane itself, and the hard segment and the hard segment. The formation of multiple hydrogen bonds between soft segments is not conducive to the formation of microphase separation structure

Therefore, the mechanical properties of polyurethane hydrogel are greatly reduced compared with polyurethane bulk materials, which limits its practical application in tissue engineering fields such as cartilage repair.

At present, polyurethane hydrogels with a compressive strength exceeding 30 MPa have not been reported.

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