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Method for preparing degradable material modified polylactic acid polymer

A polylactic acid polymer and polylactic acid technology are applied in the field of preparation of amino acid-modified polylactic acid polymers, which can solve the problems of limiting the molecular weight of the polymer, cumbersome preparation steps, low ring-opening activity, etc., and achieve lower synthesis costs and lower prices. source, effect of improving processability and biodegradability

Active Publication Date: 2015-04-08
杨凌瑞丰环保科技有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently widely used poly(lactic acid-amino acid) synthesis route is the ring-opening polymerization method of amino acid cyclic derivatives (especially morphine 22 52 diketone), but the disadvantage is that the preparation steps of various amino acid cyclic derivatives are cumbersome, The reaction time is long, and the ring-opening activity of various amino acid cyclic derivatives is not high, which limits the further increase of its polymer molecular weight

Method used

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  • Method for preparing degradable material modified polylactic acid polymer

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Effect test

Embodiment 1

[0013] Under a nitrogen atmosphere, add lactic acid, 6-aminocaproic acid, hydroxyproline, and aspartic acid into water at a mass ratio of 60:80:10:5, first dehydrate under reduced pressure at 88°C, maintain for 2 hours, then raise the temperature Further heating and dehydration at 160°C completes, and continues to heat up to 220-230°C to react to obtain poly(lactic acid-amino acid) copolymer; the poly(lactic acid-amino acid) copolymer is mixed according to the mass ratio of 90:8 and the volume ratio is 90: Reflux in 10% chloroform / methanol mixed organic solvent, remove the organic solvent, then raise the temperature to 220°C to react to obtain amino acid-modified polylactic acid polymer.

Embodiment 2

[0015] Under a nitrogen atmosphere, add lactic acid, 6-aminocaproic acid, hydroxyproline, and aspartic acid into water at a mass ratio of 70:80:13:6, first dehydrate under reduced pressure at 85°C, maintain for 2 hours, then raise the temperature Further heating and dehydration to 165°C completes, and continues to heat up to 220-230°C to react to obtain poly(lactic acid-amino acid) copolymers; poly(lactic acid-amino acid) copolymers are mixed according to the mass ratio of 100:10 and the volume ratio is 90: Reflux in 10% chloroform / methanol mixed organic solvent, remove the organic solvent, then raise the temperature to 220°C to react to obtain amino acid-modified polylactic acid polymer.

Embodiment 3

[0017] Under a nitrogen atmosphere, add lactic acid, 6-aminocaproic acid, hydroxyproline, and aspartic acid into water at a mass ratio of 50:60:7:5, first dehydrate under reduced pressure at 85°C, maintain for 2 hours, then raise the temperature Further heating and dehydration to 160°C completes, and continues to heat up to 220-230°C to react to obtain poly(lactic acid-amino acid) copolymers; the poly(lactic acid-amino acid) copolymers are mixed according to the mass ratio of 95:10 and the volume ratio is 90: Reflux in 10% chloroform / methanol mixed organic solvent, remove the organic solvent, then raise the temperature to 220°C to react to obtain amino acid-modified polylactic acid polymer.

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Abstract

The invention discloses a method for preparing an amino acid modified polylactic acid polymer. The method comprises the following steps: adding lactic acid, 6-aminocaproic acid, hydroxyproline and aspartic acid into water; dehydrating, and heating to 220-230 DEG C to react to obtain poly(lactic acid-amino acid) copolymer; and mixing polylactic acid with the poly(lactic acid-amino acid) copolymer to obtain the amino acid modified polylactic acid polymer. The preparation method adopts lactic acid as a raw material which is low in price and wide in source, so that the synthesizing cost for the amino acid modified polylactic acid polymer can be reduced, and the prepared amino acid modified polylactic acid polymer has excellent biocompatibility and biodegradability.

Description

technical field [0001] The invention relates to a preparation method of amino acid modified polylactic acid polymer, which belongs to the technical field of polymer material synthesis. Background technique [0002] Biodegradable polymer materials refer to materials that can be degraded by microorganisms or their secretions under enzymatic or chemical decomposition and finally become monomers or metabolized into CO 2 It is a polymer material with water, which has the characteristics of easy adsorption of water, low crystallinity, and high degree of linearization of molecular chains. Polylactic acid (PLA) is a biopolymer material with good biocompatibility and biodegradability and absorption in vivo. It has been widely used in the fields of medicine and pharmacy. However, the pure PLA homopolymer has defects such as high crystallinity, no reactive groups in the macromolecular chain, no hydrophilicity, long degradation cycle, and poor mechanical toughness, which limit its appl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L77/12C08G69/44
Inventor 王治
Owner 杨凌瑞丰环保科技有限公司
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