A new method for the synthesis of benzyl salicylate by solid-liquid phase transfer catalysis

Abstract

The invention relates to a novel method for catalytically synthesizing benzyl salicylate via solid-liquid phase transfer. The method comprises the following steps: adding salicylate, benzyl chloride, a catalyst A and a catalyst B in a reaction vessel for reaction at 80-200 DEG C for 2-20 h; after reaction, adding water to layer the reaction solution; separating the organic layer; carrying out washing, dehydration and reduced pressure distillation on the organic layer in sequence; collecting the fraction at 164-165 DEG C / 725-735 Pa to obtain the product, wherein the catalyst A is one or the combination of more than two of crown ether, a crown ether derivative and PEG200-6000 and the catalyst B is alkali metal haloid salt. The synthesis method provided by the invention has the advantages of being simple in process, low in energy consumption, less in pollution and high in yield and according with the international spice standard in the aspect of product quality.

Description

technical field [0001] The invention relates to the field of organic synthesis, in particular to a new method for synthesizing benzyl salicylate by solid-liquid phase transfer catalysis. Background technique [0002] Benzyl salicylate, also known as benzyl salicylate, has ambergris-like and amber-like aromas. It is often used as a diluent, admixture and fixative for floral and non-floral flavors, and is widely used in the fragrance industry. ; At the same time, it is also an additive of cosmetics, used in sunscreen cosmetics, which can protect the skin from ultraviolet rays; it can also be used as a modifier of pesticides and plastics, and as an intermediate of pharmaceutical products. [0003] At present, there are three main methods for the synthesis of benzyl salicylate. The first is a traditional synthesis method using salicylic acid and benzyl alcohol as raw materials, but the cost of benzyl alcohol is relatively high; the second is the transesterification method of me...

AI Technical Summary

Problems solved by technology

The first is a traditional synthesis method using salicylic acid and benzyl alcohol as raw materials, but the cost of benzyl alcohol is relatively high; the second is the transesterification method of methyl salicylate and benzyl alcohol, and the product yield is about 82%. , the cost is also higher; the third is a liquid-liquid phase transfer catalytic reaction with salicylic acid, alkaline water and benzyl halide as raw materials, but because benzyl halide is easy to hydrolyze in high-temperature aqueous solution, the product yield is only about 83%

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