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A kind of biological hemostatic material and its preparation method and application

The technology of hemostatic dressing and graft is applied in the field of medicine, which can solve the problems of injury and wound temperature rise, and achieve the effects of convenient operation, no temperature rise and stable performance.

Active Publication Date: 2016-02-10
郑东莲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because its hemostatic mechanism relies on the coagulation of the blood itself, it has no inhibitory effect on wound healing, but the hemostatic material achieves the purpose of hemostasis by absorbing a large amount of water in the blood, which will cause the temperature of the wound to rise and cause damage

Method used

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  • A kind of biological hemostatic material and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 acrylic resin graft

[0028] (1) Put a total of 15g of polymerized monomer acrylic acid and acrylamide (the mass ratio of acrylic acid:acrylamide is 4.5:1) in the reaction kettle, stir, and add 25% sodium hydroxide solution dropwise until the neutralization degree is 55%, to obtain the polymerization solution;

[0029] (2) Add 1.3g of pre-weighed sodium carboxymethylcellulose, 0.01g of potassium persulfate (initiator), 0.0003g of sodium bisulfite (initiator) and 0.105g of n,n-methylenebisacrylamide (Add in the form of aqueous solution, the concentration is 1g / L), microwave heating and stirring, carry out graft copolymerization reaction, the reaction temperature is 60-70 ℃, the reaction time is 2.5 hours, when the liquid is viscous, transfer it to the tray;

[0030] (3) Put the tray containing the pre-polymer into the oven quickly, polymerize and dry at 100-120°C, and after complete drying, crush it into 80-mesh particles and sieve. Afte...

Embodiment 2

[0031] The preparation of embodiment 2 acrylic resin grafts

[0032] (1) Put a total of 15g of polymerized monomer acrylic acid and acrylamide (the mass ratio of acrylic acid:acrylamide is 6:1) in the reaction kettle, stir, and add 25% sodium hydroxide solution dropwise until the neutralization degree is 55%, to obtain the polymerization solution;

[0033] (2) Add 1.5g of pre-weighed sodium carboxymethylcellulose, 0.01g of potassium persulfate (initiator), 0.0003g of sodium bisulfite (initiator) and 0.12g of n,n-methylenebisacrylamide (Add in the form of aqueous solution, the concentration is 1g / L), microwave heating and stirring, carry out graft copolymerization reaction, the reaction temperature is 60-70 ℃, the reaction time is 2.5 hours, when the liquid is viscous, transfer it to the tray;

[0034] (3) Put the tray containing the pre-polymer into the oven quickly, polymerize and dry at 100-120°C, and after complete drying, crush it into 100-mesh particles and sieve. After...

Embodiment 3

[0035] Embodiment 3 Comparative experiment of hemostatic effect

[0036] The acrylic resin prepared according to the method of the embodiment of the present invention and its grafts are compared with other comparative materials in terms of hemostasis time, blood loss, and 180-minute mortality, so as to determine the acrylic resin prepared according to the method of the embodiment of the present invention and its graft. Haemostatic effect of grafted hemostatic materials.

[0037] Experimental animals: 35 big-eared white rabbits, about half male and female, each weighing 2.5-3kg.

[0038] experimental method:

[0039] Big-eared white rabbits, about half male and female, were randomly divided into blank control group, pressurized bandaging group and drug treatment group. The weight of the dressing used in each drug treatment group was the same, 10 g, 10 rabbits in each group, and each experimental group was weighed before and after the experiment. The weight of the rabbit and t...

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Abstract

The invention provides a biological hemostatic material and its preparation method and use, in particular to a preparation method of an acrylic resin and its graft and its use. The preparation method includes: weighing the measured polymerized monomer and placing it in a neutralization tank; gradually adding an alkaline neutralizing solution under stirring, adding water to dilute the polymerized monomer to a predetermined concentration after neutralization, so as to prepare the Polymer liquid; transfer the polymerization liquid to a polymerization tray with stirring and good heat dissipation functions, add a crosslinking agent and stir; add an initiator to initiate a polymerization reaction, and make a semi-finished product after the reaction is completed; and the prepared The semi-finished product is dried at high temperature, then crushed, sieved, and sterilized to obtain the finished product.

Description

technical field [0001] The invention relates to a biological hemostatic material and its preparation method and application, belonging to the field of medicine. Background technique [0002] Common traditional local hemostatic drugs include Yunnan Baiyao, Panax notoginseng powder and thrombin, etc., and have been widely used clinically. The first two are non-soluble Chinese herbal medicines, and their application in surgery and exposed deep trauma is limited due to wound stimulation and easy formation of scars; thrombin is an active protein extracted from pig blood, which is allergic to individual people and expensive , so most patients are unacceptable. In addition, they are not effective in hemostasis of bleeding wounds caused by moderate and severe trauma. [0003] For this reason, U.S. Medafor Company has produced a kind of spongy hemostatic material with potato starch as matrix. This spongy material can absorb a large amount of water in the blood at the bleeding poin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/02C08F220/06C08F220/56C08F222/38A61L15/24A61L15/44A61L27/16A61L27/54A61K47/32
Inventor 梁勇赵伟欧阳茂海窦桂芳
Owner 郑东莲
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