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Medicinal composition for treating ankylosing spondylitis and preparation method of medicinal composition

A technology for ankylosing spondylitis and composition, applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problem of low positive rate of rheumatoid factor, dependence and side effects, unfavorable long-term use, etc. problem, to achieve the effect of no toxic side effects, exact curative effect, and short treatment course

Inactive Publication Date: 2015-07-22
袁娜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 2. Immunological examination: the positive rate of rheumatoid factor is not high
However, the above-mentioned drugs all have certain toxicity, are not conducive to long-term use, and are often used to have dependence and side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0060] When the dosage form of the pharmaceutical composition is a granule, its preparation method comprises the following steps:

[0061] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 85% to 95% that is 4 to 8 times that of the mixture, heat to boiling and reflux for 3 to 5 hours, and filter. Use the percolation method to percolate slowly at a rate of 1-2ml per minute, collect the percolation liquid, and then concentrate under reduced pressure at a vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.04-1.10 at 50-60°C. Spray drying, the air inlet temperature of the spray dryer is 160-175°C, the outlet air temperature is 80-85°C, and then crushed into powder to make dry paste powder;

[0062] In the second step, 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin are added to the obtained dry paste powder to form granules, and dried at 40-50° C. to obt...

Embodiment 1

[0071] Example 1 Granules

[0072] The production process of the granules of the present invention is as follows: take 140g of Rhizoma chinensis, 320g of Fructus Lycii, 160g of Bitter Scrophulariae, 250g of Sangji, 30g of Touguxiang, 170g of Clematis, 340g of Smilax, 250g of Boxwood, 320g of Eggplant , Zushima 30g, Citricia 220g, Fufangteng 360g, Morinda officinalis 250g, Qingteng 180g, rheumatism wood 150g, white mustard seed 300g, dragon boat flower root 280g and begonia root 160g;

[0073] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add 90% ethanol with an alcohol concentration 6 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and use the percolation method to Slowly percolate at a speed of 2ml, collect the percolation liquid, then concentrate under reduced pressure at a vacuum of 0.07Mpa to a paste with a relative density of 1.07 at 55°C, and spray dry. The air inlet temperature of t...

Embodiment 2

[0075] Example 2 Capsules

[0076] The production process of the capsule of the present invention is as follows: take 150g of Guanzhong, 260g of medlar leaves, 180g of bitter scrophulariaceae, 320g of mulberry parasites, 20g of Touguxiang, 140g of Clematis clematis, 320g of smilax, 260g of boxwood, and 380g of eggplant , Zushima 40g, Citricia 180g, Fufangteng 400g, Morinda officinalis 260g, Qingteng 180g, rheumatism wood 170g, white mustard seed 320g, dragon boat flower root 250g and begonia root 150g;

[0077] The first step is to mix the raw materials of the pharmaceutical composition in proportion, add ethanol with an alcohol concentration of 90% to 3 times the mass of the mixture, heat and reflux for 2 hours, extract, and filter to obtain the first extract; Then add ethanol with an alcohol concentration of 85% to the dregs of the dregs, heat and reflux for 2 hours, extract, and filter to obtain the second extract; combine the first extract and the second extract, and depre...

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Abstract

The invention discloses a medicinal composition for treating ankylosing spondylitis and a preparation method of the medicinal composition. The medicinal composition comprises the following various raw herbal materials: cyrtomium fortunei, holly leaf, picria fel-terrae, parasitic loranthus, radix clematidis, chinaroot greenbrier, box-wood, cat's-ear, Yunnan wintergreen stem and leaf, girald daphne bark, trifoliate acanthopanax root or root-bark, wintercreeper, morinda officinalis, sinomenium acutum, rauvolfia latifrons, semen brassicae, lysionotus pauciflorus, glabrousleaf pittosporum root, lanceolate jasmine root or stem, Chinese ixora root, evans begonia root, madder and rosette thistle herb. The medicinal composition has the benefits of effects of nourishing liver and kidney, dispelling wind and dampness and strengthening muscles and bones, combination of effects of activating meridians to stop pain and activating blood to remove stasis and advantages of high response speed, high efficiency, exact curative effect, short treatment course, no toxic or side effects, low price and the like.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating ankylosing spondylitis and a preparation method thereof. Background technique [0002] Ankylosing spondylitis (AS) is a common disease in orthopedics and rheumatology. The main symptoms are sacroiliac joint and spinal attachment inflammation, and the fibrosis and ossification of intervertebral disc annulus and its adjacent connective tissue, as well as joint ankylosis are the main symptoms. Lesion characteristics, is an autoimmune disease. In the early stage of the lesion, there is inflammatory pain in the joints, accompanied by muscle spasm around the joints, and a sense of stiffness, which is obvious in the morning. It can also be manifested as night pain, which is relieved by activities or taking analgesics. As the disease progresses, the joint pain is relieved, while the activities of the spinal segments and jo...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61K36/896A61P19/02A61P29/00
Inventor 袁娜许艳赵文健
Owner 袁娜
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