Preparation method of high-biocompatibility dual-target modified Fe3O4 nano material
A technology of biocompatibility and nanomaterials, applied in the field of preparation of functional Fe3O4 nanomaterials, can solve problems such as cumbersome synthesis steps and poor target recognition ability, achieve high relaxation rate, good biocompatibility, and facilitate The effect of mass production
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[0021] Example 1:
[0022] A dual target modified Fe with good biocompatibility 3 O 4 The preparation method of nano material, the steps are as follows:
[0023] 1) Put 0.5g FeCl in a 100mL three-necked round bottom flask 3 ·6H 2 O and 0.184g FeCl 2 ·4H 2 O dissolved in 20mLH 2 In O, dissolve with mechanical stirring, and protect with nitrogen. After 15 minutes, add 7.5 mL of 27% NH to the above solution 4 OH, then 5mL hyaluronic acid (molecular weight 6k Da, 40mg / mL) was added, and the reaction was continued for 30 min at room temperature.
[0024] 2) The Fe modified with hyaluronic acid 3 O 4 The nanomaterials are cleaned four times with high-purity water using an external magnetic field to remove reaction impurities, and then the materials are dissolved in high-purity water and stored at 4°C.
[0025] 3) Take 5ml of the hyaluronic acid modified Fe obtained in step 2) 3 O 4 Nanomaterials, use a magnet to suck out the nanomaterials, discard the supernatant, redissolve the materials i...
Example Embodiment
[0028] Example 2:
[0029] A dual target modified Fe with good biocompatibility 3 O 4 The preparation method of nano material, the steps are as follows:
[0030] 1) In a 100mL three-necked round bottom flask, add 0.25g FeCl 3 ·6H 2 O and 0.092g FeCl 2 ·4H 2 O dissolved in 20mLH 2 In O, dissolve with mechanical stirring, and protect with nitrogen. After 15 minutes, add 5 mL of 27% NH to the above solution 4 OH, then 7.5mL hyaluronic acid (molecular weight 3k Da, 40mg / mL) was added, and the reaction was continued for 30 min at room temperature.
[0031] 2) The Fe modified with hyaluronic acid 3 O 4 The nanomaterials are cleaned four times with high-purity water using an external magnetic field to remove reaction impurities, and then the materials are dissolved in high-purity water and stored at 4°C.
[0032] 3) Take 5ml of the hyaluronic acid modified Fe obtained in step 2) 3 O 4 Nanomaterials, use a magnet to suck out the nanomaterials, discard the supernatant, redissolve the materials...
Example Embodiment
[0035] Example 3:
[0036] A dual target modified Fe with good biocompatibility 3 O 4 The preparation method of nano material, the steps are as follows:
[0037] 1) Put 1g FeCl in a 100mL three-necked round bottom flask 3 ·6H 2 O and 0.368g FeCl 2 ·4H 2 O dissolved in 20mLH 2 In O, dissolve with mechanical stirring, and protect with nitrogen. After 15 minutes, add 10 mL of 27% NH to the above solution 4 OH, 10 mL hyaluronic acid (molecular weight 4k Da, 40 mg / mL) was added, and the reaction was continued for 30 min at room temperature.
[0038] 2) The Fe modified with hyaluronic acid 3 O 4 The nanomaterials are cleaned four times with high-purity water using an external magnetic field to remove reaction impurities, and then the materials are dissolved in high-purity water and stored at 4°C.
[0039] 3) Take 5ml of the hyaluronic acid modified Fe obtained in step 2) 3 O 4 Nanomaterials, use a magnet to suck out the nanomaterials, discard the supernatant, redissolve the materials in 20m...
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