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Multilayered biological composite material and preparation method thereof

A composite material and biological technology, applied in medical science, prosthesis, etc., can solve problems such as large differences in thermal expansion coefficients, affecting interface bonding, etc., to achieve high density, maintain biological activity, and improve tissue and performance.

Active Publication Date: 2015-08-19
KUNMING UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is: aiming at the current surface coating biological composite material and the problem of mixing and preparing biocomposite material, the titanium alloy with low elastic modulus is used as the matrix, the titanium alloy / ceramic is the transition layer, and the ceramic layer is the biologically active material. layer, which can not only solve the problem of interfacial bonding due to the large difference in thermal expansion coefficient between ceramics and metals, but also maintain good mechanical properties, and can greatly improve the biological activity of composite materials.

Method used

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  • Multilayered biological composite material and preparation method thereof
  • Multilayered biological composite material and preparation method thereof
  • Multilayered biological composite material and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0023](1) The titanium alloy substrate weighs Ti, Nb, Zr with a purity of 99.5%, 99.95% and 99% and an average particle size of 45 μm according to the mass percentage (wt%) of Ti60%, Nb 34%, and Zr 6.0%. Metal powder; the middle layer is Ti35%, Nb 34%, Zr 6.0%, HA25% by mass percentage (wt%) to weigh Ti, Nb, Zr with a purity of 99.5%, 99.95% and 99%, and an average particle size of 45 μm Metal powder and hydroxyapatite powder with a purity of 97% and an average particle size of 100nm have a mass of 3.4g; the surface layer of the bioceramic weighs 4g of HA powder with a purity of 97% and a particle size of 100nm.

[0024] (2) Put the titanium alloy matrix powder and the metal powder in the middle layer into the ball mill tank respectively in step (1), seal and evacuate to 20Pa with alcohol, and the ball-to-material ratio is 4:1; the titanium alloy matrix powder is mechanically After alloying ball milling for 12 hours, dry it in a vacuum drying oven at 40°C to obtain matrix mixe...

Embodiment 2

[0031] (1) In the titanium alloy matrix, according to the mass percentage (wt%) of Ti73%, Nb 25%, and Zr 2%, respectively weigh Ti, Nb with a purity of 99.5%, 99.95%, and 99%, and an average particle size of 25 μm. , Zr metal powder; the middle layer is Ti39%, Nb 25%, Zr 6.0%, HA30% by mass percentage (wt%), respectively weighs Ti with a purity of 99.5%, 99.95% and 99%, and an average particle size of 25 μm, Nb, Zr metal powder and hydroxyapatite powder with a purity of 97% and an average particle size of 10 μm have a mass of 1.6 g; the surface layer of the bioceramic weighs 2 g of HA powder with a purity of 97% and a particle size of 10 μm.

[0032] (2) Weigh the titanium alloy matrix powder and the metal powder of the middle layer in step (1) and put them into the ball milling tank respectively, seal and evacuate to 30Pa with alcohol, the ball-to-material ratio is 3:1, and the titanium alloy matrix powder is mechanically After alloying ball milling for 10 hours, dry in a vac...

Embodiment 3

[0035] (1) In the titanium alloy matrix, according to the mass percentage (wt%) of Ti65%, Nb 30%, and Zr 5%, respectively weigh Ti, Nb with a purity of 99.5%, 99.95%, and 99%, and an average particle size of 30 μm. , Zr metal powder; the middle layer is Ti38%, Nb 30%, Zr 5%, HA27% by mass percentage (wt%), respectively weighs Ti with a purity of 99.5%, 99.95% and 99%, and an average particle size of 30 μm, Nb, Zr metal powder and hydroxyapatite powder with a purity of 97% and an average particle size of 20nm have a mass of 6.6g; the surface layer of the bioceramic is 8g of HA powder with a purity of 97% and a particle size of 20nm.

[0036] (2) Put the titanium alloy matrix powder and the metal powder in the middle layer into the ball mill tank respectively in step (1), seal the vacuum with alcohol to 25Pa, the ball-to-material ratio is 4:1, and the titanium alloy matrix powder is mechanically After alloying ball milling for 10 hours, dry it in a vacuum drying oven at 40°C to ...

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Abstract

The invention discloses a multilayered biological composite material and its preparation method and belongs to the field of biomedical material preparation. According to the biological composite material, titanium alloy is used as a matrix, titanium alloy + hydroxyapatite is an intermediate layer, and hydroxyapatite is a biological ceramic surface layer. The preparation comprises the following technological steps: carrying out mechanical alloying and ball-milling on titanium, niobium and zirconium powders, and drying to obtain a matrix mixed powder; adding hydroxyapatite, ball-milling and mixing powders after mechanical alloying of titanium, niobium and zirconium powders, so as to obtain an intermediate-layer mixed powder; and respectively adding the matrix mixed powder, the intermediate-layer mixed powder and a hydroxyapatite powder to a lower layer, an intermediate layer and an upper layer of a graphite mould, sintering by a spark plasma furnace, and cooling in the furnace to obtain the multilayered biological composite material. The multilayered composite material prepared in the invention has similar mechanical properties with human bone, and biological activity of the material is greatly raised. The technology is clean, simple and low-cost, and is easy to realize industrialization.

Description

technical field [0001] The invention relates to a multilayer biocomposite material and a preparation method thereof, belonging to the field of preparation of biomedical materials. Background technique [0002] Multilayer biocomposite materials are biomedical materials composed of two or more different biomaterials, which are mainly used for the repair and replacement of human tissue and the manufacture of artificial organs. Traditional medical titanium alloy materials have high mechanical properties, and after being transplanted, it is easy to produce stress shielding with the surrounding tissues, resulting in graft failure. In addition, titanium alloy materials are biologically inert materials, which are not easy to induce the growth of surrounding tissue cells, so the combination is not firm. In the environment or after being implanted in the body, it is affected by the physiological environment, resulting in the release of metal ions or monomers, causing adverse effects o...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/12A61L27/06B22F7/02
Inventor 何正员张玉勤周荣蒋业华
Owner KUNMING UNIV OF SCI & TECH
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