Special glue for composite starch and preparation method of empty capsule of special glue

A technology for compounding starch and starch, applied in capsule delivery, medical preparations with non-active ingredients, pharmaceutical formulations, etc., can solve the problem of preventing the development and market launch of starch source hollow capsules, and it is difficult to achieve the strength, toughness and stability of hollow capsules. Starch hollow capsules and other problems, to achieve the effect of good film formation and disintegration, good dispersion and solubility, and low viscosity

Inactive Publication Date: 2015-09-02
ZHEJIANG WANLI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no real commercial starch hollow capsule of pure plant origin on the market. The reason is that it is difficult for a single type of starch to achieve the comprehensive strength, toughness, disintegration within 10 minutes, and stab

Method used

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  • Special glue for composite starch and preparation method of empty capsule of special glue
  • Special glue for composite starch and preparation method of empty capsule of special glue
  • Special glue for composite starch and preparation method of empty capsule of special glue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment one: the preparation method of compound starch special glue, comprises the following steps:

[0038] 1) Raw material pretreatment: all raw materials are pulverized through a 100-mesh sieve and set aside;

[0039]2) Weighing: Weigh 3500g of acetate starch, 4000g of oxidized hydroxypropyl starch, 250g of hydroxypropyl starch, 600g of maltodextrin, 335g of κ-carrageenan, 825g of glycerin, and 105g of potassium chloride by weight percentage;

[0040] 3) Mixing: first mix a small amount of starch with maltodextrin, carrageenan, glycerin, and potassium chloride evenly, then add the rest of the starch according to the equal gradient addition method and mix evenly;

[0041] 4) Making soft materials and granules: using wet granulation technology, in a high-speed mixing granulator, spray the mixed raw materials with 50% ethanol aqueous solution to make soft materials, and pass through a 10-14 mesh sieve to obtain a particle size of 1 ~2mm wet particles;

[0042] 5) D...

Embodiment 2

[0043] Embodiment two: the method for preparing composite starch hollow capsules as a raw material with the special rubber particles obtained in embodiment one may further comprise the steps:

[0044] 1) Ingredients and sol: Weigh 12.95 kg of special rubber particles, disperse them into 20 kg of water, stir to obtain a starch emulsion, add the starch emulsion into 50 kg of boiling water in a trickle under constant stirring, stir evenly, and heat at 90°C Stir the glue until it becomes transparent. Take a certain amount of glue and dilute it to a glue with a solid content of 2%, and measure its light transmittance at 50°C and a wavelength of 500nm to be 82%;

[0045] 2) Degassing of gelatinization: After the sol is completed, degassing at a temperature of 50-65°C for 1-4 hours;

[0046] 3) Measure and adjust the viscosity: at 45-55°C, measure the viscosity of the glue to be 320-580mPa.S;

[0047] 4) Embryo making: Select a suitable type of capsule mold smeared with peanut oil,...

Embodiment 3

[0049] Embodiment three: the preparation method of composite starch special glue, comprises the following steps:

[0050] 1) Raw material pretreatment: all raw materials are pulverized through a 100-mesh sieve and set aside;

[0051] 2) Weighing: Weigh 5250g of acetate starch, 5460g of oxidized hydroxypropyl starch, 160g of hydroxypropyl distarch phosphate, 700g of maltodextrin, 420g of k-carrageenan, 600g of glycerin, and 140g of potassium chloride by weight percentage;

[0052] 3) Mixing: first mix a small amount of starch with maltodextrin, carrageenan, glycerin, and potassium chloride evenly, then add the rest of the starch according to the equal gradient addition method and mix evenly;

[0053] 4) Making soft materials and granules: using wet granulation technology, in a high-speed mixing granulator, spray the mixed raw materials with 50% ethanol aqueous solution to make soft materials, and pass through a 10-16 mesh sieve to obtain a particle size of 0.8 ~2mm wet particl...

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Abstract

The invention discloses special glue for composite starch. The special glue is prepared from the following components in percentage by weight: 50 to 85% of starch, 1 to 6.5% of gel, 0.1 to 5% of coagulant aid, 2 to 15% of a plastification humectants, 0 to 15% of a disintegration accelerant, 0 to 0.5% of food coloring, and 0 to 3% of an opacifying agent. The special glue for composite starch is a plant-based empty capsule of which the main raw material is food starch, so that the biological compatibility of a human body is high. A composite starch empty capsule prepared by using the special glue for the composite starch as the raw material can subjected to one feeding, is simple to operate, small in glue maintaining and deaerating time and applicable to a gelatin empty capsule production line, and prevents an operator from dust pollution of raw material. The empty capsule prepared by using the special glue for the composite starch as the raw material contains 7 to 11% of water, difficultly absorbs moisture under normal room temperature and humidity, is difficult to crack, difficultly causes microorganism and is free of a preservative, and meets the requirement of National Formulary on pharmaceutical pharmacy index of empty capsules; the empty capsule prepared from the composite starch is true plant-based empty capsule and suitable for all people.

Description

technical field [0001] The invention relates to a hollow capsule and its preparation, in particular to a novel pure plant-sourced composite starch special glue with composite starch as a raw material and a method for preparing the hollow capsule thereof. Background technique [0002] Empty capsules are the most commonly used filling carriers for modern medicines, health products and dietary supplements. In my country, more than 95% of empty capsules are made of gelatin made from pig or cow skin and bone. Obviously, the scope of application of this type of hollow capsules is not as popular as that of plant-based raw materials. It is an inevitable trend for the development of this industry to replace animal-derived hollow capsules with plant-derived hollow capsules. To be popularized in the market, plant-derived empty capsules need to have: (1) good human compatibility and safety; (2) have the same product performance as gelatin empty capsules (such as disintegration, toughne...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/48
Inventor 刘利萍陈虹路春玲潘春洋钱国英
Owner ZHEJIANG WANLI UNIV
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