Preparation method of chitosan/hydroxyapatite magnetic bone repair support material

A technology for hydroxyapatite and scaffolding materials, applied in the field of chemical and biological engineering materials, can solve the problems of poor biocompatibility and limited sources, and achieve the effects of good mechanical properties, easy operation and excellent biocompatibility

Inactive Publication Date: 2015-09-09
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are problems of limited sources, poor biocompatibility, and severe rejection, so it is of great significance to develop bone repair materials that can repair or improve tissue or organ functions

Method used

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  • Preparation method of chitosan/hydroxyapatite magnetic bone repair support material
  • Preparation method of chitosan/hydroxyapatite magnetic bone repair support material
  • Preparation method of chitosan/hydroxyapatite magnetic bone repair support material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Dissolve formic acid (mass percentage concentration: 2%) in water to prepare a formic acid aqueous solution with a mass percentage concentration of 2.5%, dissolve chitosan in the formic acid solution at a ratio of 0.4g / mL, and heat the lower shell in a water bath at 50°C After the polysaccharide is completely dissolved, let it stand for 1 hour to defoam;

[0032] (2) Dissolving phosphoric acid (mass percentage concentration is 85%) in the solution obtained in step (1), then adding distilled water to dilute to obtain phosphoric acid solution, the volume percent concentration of phosphoric acid in the phosphoric acid solution is 0.1%;

[0033] (3) Dissolve calcium hydroxide in water at a ratio of 1.25g / mL, and stir well to obtain calcium salt lye;

[0034] (4) According to the ratio of calcium hydroxide to phosphoric acid molar ratio of 1.5:1, co-titrate the phosphoric acid solution obtained in step (2) and the calcium salt alkali solution obtained in step (3) in the ...

Embodiment 2

[0040] (1) Dissolve citric acid (3% by mass) in water to prepare a citric acid aqueous solution with a concentration of 4% by mass, dissolve chitosan in the citric acid solution at a ratio of 0.5g / mL, and place in a 60°C water bath Stand still 1.5h degassing after chitosan dissolves completely under heating;

[0041] (2) Dissolve phosphoric acid (mass percentage concentration is 87%) in the solution obtained in step (1), then add distilled water to dilute to obtain phosphoric acid solution, the volume percent concentration of phosphoric acid in the phosphoric acid solution is 0.15%;

[0042] (3) Dissolve calcium hydroxide in water at a ratio of 1.4g / mL, and stir well to obtain calcium salt lye;

[0043] (4) According to the ratio of calcium hydroxide to phosphoric acid molar ratio of 1.6:1, co-titrate the phosphoric acid solution obtained in step (2) and the calcium salt alkali solution obtained in step (3) in the aqueous solution, and co-precipitate for 8 hours. Wherein the ...

Embodiment 3

[0049] (1) Dissolve lactic acid (4% by mass) in water to prepare an aqueous lactic acid solution with a concentration of 5% by mass, dissolve chitosan in the lactic acid solution at a ratio of 0.6g / mL, and heat the lower shell in a water bath at 70°C After the polysaccharide is completely dissolved, let it stand for 2 hours to defoam;

[0050] (2) Dissolving phosphoric acid (mass percentage concentration is 89%) in the solution obtained in step (1), then adding distilled water to dilute to obtain phosphoric acid solution, the volume percent concentration of phosphoric acid in the phosphoric acid solution is 0.2%;

[0051] (3) Dissolve calcium hydroxide in water at a ratio of 1.5g / mL, and stir well to obtain calcium salt lye;

[0052] (4) According to the ratio of calcium hydroxide to phosphoric acid molar ratio of 1.7:1, co-titrate the phosphoric acid solution obtained in step (2) and the calcium salt alkali solution obtained in step (3) in the aqueous solution, and co-precipi...

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Abstract

The invention discloses a preparation method of a chitosan/hydroxyapatite magnetic bone repair support material, and belongs to the field of chemical and biological engineering materials. The method specifically comprises the steps that chitosan/hydroxyapatite nano-composite powder is prepared; magnetic nano-powder, the chitosan/hydroxyapatite nano-composite powder and pore forming substance particles are evenly mixed; then binder silica sol and water are added to be fully mixed to obtain needed slurry; and extrusion forming, drying, demolding, pore forming substance removal and sintering are carried out on the slurry to obtain a composite support. The method is simple and convenient to operate, and the porosity of the obtained support is high. Mechanical performance is good and is equivalent to cancellous bone performance. The cancellous bone repair need can be met, certain magnetism is achieved, and the proliferation and differentiation of osteoblast can be stimulated. Hydroxyapatite in the composite powder is distributed in a chitosan matrix in a needle shape with nanometer as the scale, biocompatibility can be improved, the toxic reaction of cells can be reduced, and the good application prospect is achieved.

Description

technical field [0001] The invention specifically relates to a preparation method of a chitosan / hydroxyapatite magnetic bone repair scaffold material, which belongs to the field of chemical and biological engineering materials. Background technique [0002] The repair of bone defects caused by trauma, tumors and congenital diseases has always been a difficult problem in the clinical treatment process. At present, the common methods for clinical treatment of bone defects are autologous bone grafting, allogeneic bone grafting and the use of metal substitute materials. However, there are problems of limited sources, poor biocompatibility, and severe rejection, so it is of great significance to develop bone repair materials that can repair or improve tissue or organ functions. Hydroxyapatite is the main component of bone tissue. It has excellent biocompatibility, osteoconductivity, osteoinductivity, and forms a tight bone bond with the host. Calcium ions and phosphate ions rel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/58A61L27/50A61L27/40A61L27/12A61L27/20
Inventor 陈庆华尹研婷颜廷亭
Owner KUNMING UNIV OF SCI & TECH
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