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A kind of mg-ca-sr-zn series magnesium alloy and its preparation method and application

A technology of magnesium alloy and synthesis method, which is applied in the fields of surgery, coating, medical science, etc., and can solve problems such as low corrosion resistance

Active Publication Date: 2017-06-30
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of magnesium in engineering applications is low corrosion resistance, but this disadvantage has become its advantage as a biomaterial: magnesium can be degraded into soluble non-toxic oxides in the body and excreted harmlessly from intestinal tissue outside the body

Method used

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  • A kind of mg-ca-sr-zn series magnesium alloy and its preparation method and application
  • A kind of mg-ca-sr-zn series magnesium alloy and its preparation method and application
  • A kind of mg-ca-sr-zn series magnesium alloy and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Embodiment 1, preparation cast state Mg-Ca-Sr-Zn series magnesium alloy

[0090] The test raw materials are pure Mg (99.7wt%), Ca powder (99.8wt%), Sr powder (99.9wt%) and Zn powder (99.5wt%), according to different proportions, as shown in Table 1, at 670 ° C , smelting under the protective atmosphere of Ar gas (99.99%), after the experimental material is fully melted, it is kept for 40 minutes, and then the molten material is poured into the pre- In the designed mold, as-cast Mg-Ca-Sr-Zn magnesium alloys with different proportions were prepared.

[0091] Table 1, the Mg-1Ca-xSr-yZn series magnesium alloy prepared in Example 1

[0092] sample x value y value sample x value y value Sample 1-1 0.2 2 Sample 1-7 1 2 Sample 1-2 0.2 4 Sample 1-8 1 4 Sample 1-3 0.2 6 Samples 1-9 1 6 Sample 1-4 0.5 2 Samples 1-10 2 2 Sample 1-5 0.5 4 Samples 1-11 2 4 Sample 1-6 0.5 6 Sample 1-12 2 6

[...

Embodiment 2

[0095] Embodiment 2, preparation extruded state Mg-Ca-Sr-Zn series magnesium alloy

[0096] Firstly, the as-cast Mg-1Ca-xSr-yZn alloy ingots of different proportions are prepared according to the steps in Example 1 (the proportioning ratio is shown in Table 1), and then all are processed as follows: the ingot is processed into Φ39.6mm× 50mm size, solid solution treatment at 340°C for 4 hours; preheat the ingot to 340°C and keep it warm for 20 minutes, the temperature of the mold and the extrusion cylinder are both 295°C, the extrusion temperature is 320°C, and the extrusion speed is 2mm / s, the extrusion ratio was 16, and the extruded Mg-1Ca-xSr-yZn magnesium alloy (sample 2-12) was prepared, as shown in Table 2.

[0097] Table 2 Example 2 prepared Mg-1Ca-xSr-yZn series magnesium alloy

[0098] sample x value y value sample x value y value Sample 2-1 0.2 2 Sample 2-7 1 2 Sample 2-2 0.2 4 Sample 2-8 1 4 Sample 2-3 0.2 6 Sample...

Embodiment 3

[0101] Embodiment 3, performance test of Mg-Ca-Sr-Zn series magnesium alloy

[0102] (1) Tensile properties at room temperature

[0103] The extruded Mg-Ca-Sr-Zn series magnesium alloy (sample 1-12) prepared in Example 2 was all prepared according to the ASTM-E8-04 tensile test standard, and the SiC sandpaper was polished to 2000# , using a general material tensile testing machine to carry out the tensile test at room temperature, the tensile speed is 0.5mm / min, the results are as follows image 3 shown.

[0104] Depend on image 3 It can be seen that the yield strength of the extruded Mg-Ca-Sr-Zn series magnesium alloy is 100-150 MPa, the tensile strength is 125 MPa-250 MPa, and the elongation at break is 2%-35%. When the Sr content is 0.2wt.% and 1wt.%, the yield strength and tensile strength of the alloy increase with the increase of Zn content, but the elongation at break of the alloy decreases with the increase of Zn content in the alloy . When the Sr content was 0.5...

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Abstract

The invention discloses a Mg-Ca-Sr-Zn series magnesium alloy, a preparation method and application thereof. The magnesium alloy is composed of Mg, Ca, Sr and Zn; by weight percentage, in the magnesium alloy, the content of Ca is 0-5%, but not 0, and the content of Sr is 0-5%, but not 0, the content of Zn is 0-10%, but not 0, and the rest is Mg. The present invention regulates the mechanical properties and degradation speed of medical implants through the cooperation of composition design and preparation process, and obtains the best mechanical properties and corrosion resistance; it has better biocompatibility, mainly manifested in higher biocompatibility Cell survival rate, and the cell survival rate does not decrease significantly with the prolongation of culture time, has high ALP activity, good compatibility of red blood cells and hemoglobin; selects essential metal elements for human body, does not contain harmful or potentially harmful elements, of which The alloying element Sr in Mg-Ca-Sr-Zn series magnesium alloy can promote osteogenesis and inhibit bone resorption, so the local release of Sr along with the degradation of Mg‑Ca‑Sr‑Zn series magnesium alloy can promote tissue healing.

Description

technical field [0001] The invention relates to a Mg-Ca-Sr-Zn series magnesium alloy and its preparation method and application, in particular to a Mg-Ca-Sr-Zn series magnesium alloy and its preparation method and its use in the preparation of body fluid degradable medical implants The application in the present invention belongs to the field of medical metal material preparation. Background technique [0002] At present, biodegradable materials widely used clinically are mainly degradable polymer materials, degradable ceramic materials and degradable metal materials. Degradable polymer materials include polylactic acid (PLA), polycaprolactone (PCL), polyglycolic acid (PGA) and polylactic-co-glycolic acid (PLGA), as well as natural polysaccharides (cellulose, chitin) and natural Protein materials (collagen, fibrin), etc. Degradable ceramic materials mainly include hydroxyapatite (HA) and β-tricalcium phosphate. Although degradable polymer materials can be completely absor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C23/04C22C23/00C22F1/06A61L31/02A61L31/10A61L31/08A61L31/14
Inventor 郑玉峰吴远浩李楠刘洋成艳
Owner PEKING UNIV
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