Medicine composition for treating mycoplasmal pneumonia and preparation method thereof

A technology of Mycoplasma pneumoniae and a composition, which is applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as long half-life, and achieve the effects of fast onset, no toxic and side effects, and high efficiency.

Inactive Publication Date: 2015-10-21
吴强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the long half-life, the drug effect can last for 1 week after stopping the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0068] When the dosage form of the pharmaceutical composition is a granule, its preparation method comprises the following steps:

[0069] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 85% to 95% that is 4 to 8 times that of the mixture, heat to boiling and reflux for 3 to 5 hours, and filter. Use the percolation method to percolate slowly at a rate of 1-2ml per minute, collect the percolation liquid, and then concentrate under reduced pressure at a vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.04-1.10 at 50-60°C. Spray drying, the air inlet temperature of the spray dryer is 160-175°C, the outlet air temperature is 80-85°C, and then crushed into powder to make dry paste powder;

[0070] In the second step, 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin are added to the obtained dry paste powder to form granules, and dried at 40-50° C. to obt...

Embodiment 1

[0079] Example 1 Granules

[0080]The preparation process of the granules of the present invention is as follows: get 30 g of lobelia, 120 g of June cold, 160 g of citrus aurantium, 220 g of arctium, 300 g of platycodon, 420 g of horsetail, 330 g of houttuynia, 150 g of licorice, 340 g of Zijinniu, 150 g of ginger, 350g of seeds, 140g of magnets, 300g of cistanche, 200g of bamboo leek, 350g of plantain seeds, 120g of white mustard seeds, 280g of halberd leaf wawe, 150g of perilla seeds, 200g of agarwood, 350g of mulberry bark, 160g of raspberries, 200g of Tibetan green fruits , Tinglizi 300g, Yizhiren 130g, Tingli 320g, Wanzhangshen 220g and Domino Fern 260g;

[0081] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 85% to 95% that is 4 to 8 times that of the mixture, heat to boiling and reflux for 3 to 5 hours, and filter. Use the percolation method to percolate slowly at ...

Embodiment 2

[0083] Example 2 Capsules

[0084] The manufacture process of the capsule of the present invention is: get lobelia 40g, June Han 160g, Citrus aurantium 320g, burdock 220g, bellflower 140g, horsetail 420g, houttuynia 330g, licorice 150g, Zijinniu 280g, ginger 170g, pedicel 350g of seeds, 130g of magnets, 240g of cistanche, 180g of bamboo leek, 260g of plantain seeds, 150g of white mustard seeds, 300g of halberd leaf Wawei, 140g of perilla seeds, 230g of agarwood, 320g of mulberry bark, 200g of raspberries, and 300g of Tibetan green fruits , Tinglizi 400g, Yizhiren 160g, Tingli 330g, Wanzhangshen 170g and Domino Fern 270g;

[0085] The first step is to mix the raw materials of the pharmaceutical composition in proportion, add ethanol with an alcohol concentration of 90% that is three times the mass of the mixture, heat and reflux for 3 hours, extract, and filter to obtain the first extract; Then add ethanol with an alcohol concentration of 85% to the dregs of the dregs, heat an...

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PUM

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Abstract

The invention discloses a medicine composition for treating mycoplasmal pneumonia and a preparation method thereof. The medicine composition comprises the raw materials of lobelia, herbs of threeflower bluebeard, fructus aurantii, great burdock achene, stemona tubers, balloon flowers, meadowrue roots and rhizomes, heartleaf houttuynia herbs, liquorice, Japanese ardisia, Japanese metaplexis, Indian Kalimeris herbs, ginger, thorny elaeagnus fruits, magnetite, Russian boschniakia herbs, bamboo juice, plantain seeds, white mustard seeds, narrow-leaf lepisorus, tabasheer, perilla fruits, agilawood, white mulberry root-bark, raspberries, immature fruits of medicine terminalia, pepperweed seeds, sharpleaf galangal fruits, pennycress, woody hawkbeard roots, wallich eriophyton and lemmaphyllum subrostratum. The medicine composition has the advantages that the effects of clearing away heat through releasing the lungs, regulating the lungs, relieving asthma and reducing phlegm are achieved, meanwhile, the effects of tonifying the kidneys, removing blood stasis, promoting urination and replenishing vital essence to cultivate qi are achieved, the medicine composition takes effect rapidly, is high in effective rate and free of toxic and side effects and has a definite treatment effect, the treatment course is short, and the price is low.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating mycoplasma pneumoniae pneumonia and a preparation method thereof. Background technique [0002] Mycoplasma pneumoniae pneumonia is an acute lung infection caused by Mycoplasma pneumoniae, mainly caused by interstitial lesions. The clinical manifestations of this type of pneumonia are significantly different from those caused by common bacteria such as Streptococcus pneumoniae, and β-lactam antibiotics and Treatments such as sulfa drugs are ineffective, so it is clinically referred to as "primary atypical pneumonia" together with pneumonia caused by other atypical pathogens such as Legionella pneumophila, Chlamydia pneumoniae, and Rickettsia. In recent years, atypical pathogens, especially Mycoplasma pneumoniae, have been found to be the main pathogens of community-acquired pneumonia. [0003] Symptoms of Mycoplasma ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P31/04A61P11/00A61K33/26
Inventor 吴强
Owner 吴强
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