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Grafted copolymer preparing method based on chitosan and polylactic acid

A technology of graft copolymer and chitosan acetic acid, which is applied in the field of preparation of functional polymer materials, can solve the problems of low grafting rate, large amount of organic solvent residue, poor dispersibility, etc., and achieve high grafting rate and organic solvent The effect of less residue and easy operation

Active Publication Date: 2015-10-28
磐升生物工程集团有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention solves the problems of the chitosan-polylactic acid graft copolymer in the prior art, such as large amount of residual organic solvent, poor dispersibility, low grafting rate, etc., and provides a low-cost, safe and convenient method for preparing chitosan - Preparation technology of polylactic acid graft copolymer

Method used

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  • Grafted copolymer preparing method based on chitosan and polylactic acid
  • Grafted copolymer preparing method based on chitosan and polylactic acid
  • Grafted copolymer preparing method based on chitosan and polylactic acid

Examples

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preparation example Construction

[0027] (3) preparation of chitosan-polylactic acid graft copolymer

[0028] Add the prepared chitosan acetic acid solution dropwise to the above reaction system, and stir the reaction at room temperature for 48 hours. After the reaction is completed, pour the solution into the methanol / NaOH solution, stir and centrifuge to separate out the precipitate, and use methanol, ethanol and water successively. The precipitate was washed and freeze-dried to obtain the product.

example 1

[0031] (1) configuration of chitosan acetic acid solution

[0032] First measure 10ml of glacial acetic acid to a constant volume of 1000ml, and configure an aqueous acetic acid solution with a concentration of 1% (v / v); then weigh 0.5g of chitosan in a beaker, add 100ml of acetic acid solution, heat and stir at 60°C, and wait until the shell After the polysaccharide is fully dissolved, it is cooled, and the constant volume is 250ml, and it is configured into a chitosan acetic acid solution with a concentration of 2mg / ml.

[0033] (2) Activated polylactic acid

[0034] Weigh 0.2g of polylactic acid with a molecular weight of 10000 and dissolve it in a 250ml three-necked flask filled with 20ml of dichloromethane; weigh 1.085g of MES in a beaker, add 50ml of distilled water to stir and dissolve, and set the volume to 100ml to prepare 50mmol / l MES For the buffer solution, take 40ml of the buffer solution and put it into a three-necked flask, add EDC / NHS at a ratio of 2:1, protec...

example 2

[0038] (1) configuration of chitosan acetic acid solution

[0039] First measure 10ml of glacial acetic acid to a constant volume of 1000ml, and configure an aqueous acetic acid solution with a concentration of 1% (v / v); then weigh 0.5g of chitosan in a beaker, add 100ml of acetic acid solution, heat and stir at 60°C, and wait until the shell After the polysaccharide is fully dissolved, it is cooled, and the constant volume is 250ml, and it is configured into a chitosan acetic acid solution with a concentration of 2mg / ml.

[0040] (2) Activated polylactic acid

[0041] Weigh 0.2g of polylactic acid with a molecular weight of 20,000 and dissolve it in a 250ml three-neck flask filled with 20ml of methylene chloride; weigh 1.085g of MES in a beaker, add 50ml of distilled water to stir and dissolve, and set the volume to 100ml to prepare a 50mmol / l MES buffer solution, take 40ml of buffer solution into a three-necked flask, add EDC / NHS at a ratio of 1:1, protect with nitrogen, an...

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Abstract

The invention relates to a grafted copolymer preparing method based on chitosan and polylactic acid. The chitosan and polylactic-acid grafted copolymer is prepared with a 1-ethyl-(3-dimethyllaminopropyl)carbodiie hydrochlide (EDC) and N-hydroxysuccinimide (NHS) condensation system as coupling agents. According to the grafted copolymer preparing method, the preparing conditions include the normal temperature and the normal pressure, the preparing process is safe, convenient and rapid, and residual organic solvents are few; the particle diameter of prepared chitosan and polylactic-acid particles ranges from 4 micrometers to 10 micrometers, the surface appearance is regular, the good dispersity and the good stability are achieved, and the prepared particles can be used as carrier materials for targeted drug delivering.

Description

technical field [0001] The invention relates to a preparation method of a functional polymer material, in particular to a preparation method based on chitosan-polylactic acid graft copolymer. The obtained copolymer particles can be applied to medicine, bioengineering, environment, food, etc. field. Background technique [0002] Chitosan is the only alkaline polysaccharide in nature. There are many free amino groups, hydroxyl groups and N-acetylamino groups distributed on the molecular chain. These functional groups make it possible to chemically react with various substances. Therefore, chitosan and its derivatives It has many unique physical and chemical properties and biological activities, such as biodegradability, bacteriostasis, antitumor activity, mucoadhesiveness, moisture retention, etc. In view of these excellent properties, chitosan and its derivatives are widely used in biomedicine to make scaffolds for tissue engineering, dressings for wound repair, carriers for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00
Inventor 詹世平刘楠陈淑花李鸣明
Owner 磐升生物工程集团有限公司
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